Cited by 254Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchAmyloidosis: Diagnosis, Treatment, Outcomes

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ALSFRS-R score and its ratio: A useful predictor for ALS-progression

Kollewe, Katja, Mauss, Ulrike, Krampfl, Klaus, Petri, Susanne, Dengler, Reinhard, Mohammadi, Bahram·2008·Journal of the Neurological Sciences

DOI 10.1016/j.jns.2008.07.016

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Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. To determine predictors of survival, we studied different parameters in our ALS Database including 479 patients. The effects of individual prognostic factors of survival were studied using Kaplan-Meier life table. The prognostic value of each factor of interest was expressed in terms of a hazard ratio. Survival from symptom-onset ranged from 4 months up to 11.9 years. Gender had no effect on survival in our cohort. However, age, site of onset, forced vital capacity, symptom duration and ALSFRS-R score at the first visit were independent prognostic factors in our population (log-rank p<0.01). The ratio of ALSFRS-R score between first symptom and first examination, during whole disease or within 100 days, correlates with survival time. We conclude that the ratio of ALSFRS-R score within 100 days is a useful parameter for clinical trials and daily clinical work in a tertiary ALS-clinic.

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Authors: Kollewe, K., Mauss, U., Krampfl, K., Petri, S., Dengler, R., & Mohammadi, B.
Affiliations: Medizinische Hochschule Hannover (DE)
Corresponding author: Mohammadi, Bahram
ORCID: Petri, Susanne
Dengler, Reinhard
Mohammadi, Bahram
Venue: Journal of the Neurological Sciences
Publisher: Elsevier BV
Published: 2008-12
Volume: 275
Issue: 1-2
Pages: 69-73
ISSN: 0022-510X (ISSN-L)
DOI: 10.1016/j.jns.2008.07.016
OpenAlex: W2026980091
Cited by: 253
References: 38
Citations by year: 2026: 8 · 2025: 11 · 2024: 18 · 2023: 15 · 2022: 21 · 2021: 13 · 2020: 15 · 2019: 18 · 2018: 26 · 2017: 15 · 2016: 19 · 2015: 23 · 2014: 15 · 2013: 7 · 2012: 11
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the Neurological Sciences (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Health Sciences › Medicine › Internal Medicine › Amyloidosis: Diagnosis, Treatment, Outcomes
Keywords: amyotrophic lateral sclerosis, ALSFRS-R, disease progression, survival prediction, prognostic factors, symptom onset, age, forced vital capacity, symptom duration, hazard ratio
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Cohort Studies, Age of Onset, Disease Progression, Kaplan-Meier Estimate

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ALSFRS-R score and its ratio: A useful predictor for ALS-progression

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