Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: Similarities and differences
Abstract
In Parkinsons disease and multiple system atrophy (MSA), cardiovascular dysfunction may occur for a variety of reasons and may manifest itself through inappropriate changes and/or levels in blood pressure, heart rate and/or regional vascular perfusion in a range of situations. The early occurrence of orthostatic hypotension often leads to consideration of MSA, especially in the presence of other features of autonomic failure. Orthostatic hypotension, however, is increasingly recognised in PD, and especially with increasing age, severity of disease and as a result of drug therapy, sometimes for associated disorders. Investigation of cardiovascular autonomic dysfunction in Parkinsonism is therefore important for a variety of reasons, that include determining the precise diagnosis and in predicting prognosis. In Parkinsonian disorders, understanding the pathophysiological basis of the cardiovascular autonomic dysfunction aids targeting of therapy, improves management strategies and provides benefit for such patients.
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In elderly Parkinson's disease patients, orthostatic hypotension may mainly occur after food intake.
“In elderly PD patients, this may mainly occur after food intake (Iodice et al. 2011).”
From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Iodice et al. 2011
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- Authors
- Iodice, V., Low, D. A., Vichayanrat, E., & Mathias, C. J.
- Affiliations
- St Mary's Hospital (GB)
- Corresponding author
- Mathias, Christopher J.
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 310
- Issue
- 1-2
- Pages
- 133-138
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2060932934
- Cited by
- 81
- References
- 96
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 13 · 2013: 5 · 2012: 8
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- cardiac autonomic dysfunction, multiple system atrophy, Parkinson's disease, orthostatic hypotension, autonomic failure, blood pressure, heart rate, parkinsonism, differential diagnosis, prognosis
- MeSH terms
- Autonomic Nervous System Diseases, Cardiovascular System, Humans, Hypotension, Orthostatic, Parkinson Disease, Multiple System Atrophy, Early Diagnosis
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