Cited by 81Cardiovascular Syncope and Autonomic DisordersParkinson's Disease Mechanisms and TreatmentsHeart Rate Variability and Autonomic Control

Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: Similarities and differences

Iodice, Valeria, Low, David A., Vichayanrat, Ekawat, Mathias, Christopher J.·2011·Journal of the Neurological Sciences

Abstract

In Parkinsons disease and multiple system atrophy (MSA), cardiovascular dysfunction may occur for a variety of reasons and may manifest itself through inappropriate changes and/or levels in blood pressure, heart rate and/or regional vascular perfusion in a range of situations. The early occurrence of orthostatic hypotension often leads to consideration of MSA, especially in the presence of other features of autonomic failure. Orthostatic hypotension, however, is increasingly recognised in PD, and especially with increasing age, severity of disease and as a result of drug therapy, sometimes for associated disorders. Investigation of cardiovascular autonomic dysfunction in Parkinsonism is therefore important for a variety of reasons, that include determining the precise diagnosis and in predicting prognosis. In Parkinsonian disorders, understanding the pathophysiological basis of the cardiovascular autonomic dysfunction aids targeting of therapy, improves management strategies and provides benefit for such patients.

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Crossref · 10.1016/j.jns.2011.07.014

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  • In elderly Parkinson's disease patients, orthostatic hypotension may mainly occur after food intake.

    “In elderly PD patients, this may mainly occur after food intake (Iodice et al. 2011).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Iodice et al. 2011

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Authors
Iodice, V., Low, D. A., Vichayanrat, E., & Mathias, C. J.
Affiliations
St Mary's Hospital (GB)
Corresponding author
Mathias, Christopher J.
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2011-11
Volume
310
Issue
1-2
Pages
133-138
ISSN
0022-510X (ISSN-L)
OpenAlex
W2060932934
Cited by
81
References
96
Citations by year
2026: 2 · 2025: 5 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 13 · 2013: 5 · 2012: 8
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
cardiac autonomic dysfunction, multiple system atrophy, Parkinson's disease, orthostatic hypotension, autonomic failure, blood pressure, heart rate, parkinsonism, differential diagnosis, prognosis
MeSH terms
Autonomic Nervous System Diseases, Cardiovascular System, Humans, Hypotension, Orthostatic, Parkinson Disease, Multiple System Atrophy, Early Diagnosis

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