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Cited by 54

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case–control study

Bocca, Beatrice, Forte, Giovanni, Oggiano, Riccardo, Clemente, Simonetta, Asara, Yolande, Peruzzu, Angela, Farace, Cristiano, Pala, Salvatore, Fois, Alessandro Giuseppe, Pirina, Pietro, Madeddu, Roberto·2015·Journal of the Neurological Sciences
DOI 10.1016/j.jns.2015.10.023
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Abstract

The association between exposure to toxic metals and amyotrophic lateral sclerosis (ALS) was explored in a population-based case-control study in the Sardinia island (Italy), a region characterized by elevated rates of ALS cases. In 34 patients with ALS (mean age, 62 ± 10 years) and 30 controls (mean age, 65 ± 11 years), Al, Cd, Hg, Mn and Pb were determined in blood, hair and urine by sector field inductively coupled mass spectrometry. Results indicated that, in blood, concentrations of Al (p=0.045) and Pb were higher (p=0.026) in ALS patients than in control subjects. In hair, a depletion of Al (p=0.006) and Mn (p=0.032) concentrations in ALS subjects respect to controls was found. In urine, no significant differences between cases and controls were observed. Thus, some metals seemed to be associated with ALS degeneration, but a definitive conclusion is still far considering the multiple risk factors (genetic mutations, environmental toxicants and stressors) involved in the disease. Finally, the interpretation that deregulated metal concentrations can be a consequence of the degenerative process, rather than a cause, is also valid.

Overview

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Crossref · 10.1016/j.jns.2015.10.023

Cites

88 of 88 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 88 references

Research works printed but not linked: 2

  1. Albers, 2009, Lead exposure and amyotrophic lateral sclerosis in a Northern California population, Neuroepidemiology, 33, 74
  2. Rao, 1999, Trace elements in the cerebrospinal fluid in Alzheimer’s disease, Alz Rep, 2, 333

Cited by

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Metadata

Authors
Bocca, B., Forte, G., Oggiano, R., Clemente, S., Asara, Y., Peruzzu, A., Farace, C., Pala, S., Fois, A. G., Pirina, P., & Madeddu, R.
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2015-12
Volume
359
Issue
1-2
Pages
11-17
ISSN
0022-510X
DOI
10.1016/j.jns.2015.10.023
Cited by
54
References
88
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case–control study. https://app.cochat.ai/papers/10.1016/j.jns.2015.10.023
The paper
Bocca, B., Forte, G., Oggiano, R., Clemente, S., Asara, Y., Peruzzu, A., Farace, C., Pala, S., Fois, A. G., Pirina, P., & Madeddu, R. (2015). Level of neurotoxic metals in amyotrophic lateral sclerosis: A population-based case–control study. Journal of the Neurological Sciences. https://doi.org/10.1016/j.jns.2015.10.023

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.