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Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats
Abstract
We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.
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“Among seaweed-derived peptides, species such as Undaria pinnatifida (Phaeophyceae), Neopyropia yezoensis (formerly Porphyra yezoensis) (Rhodophyta), Ulva rigida, and Ulva clathrata (formerly Enteromorpha clathrata) have shown ACE inhibitory activity [53–57].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [53]
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“Among seaweed-derived peptides, species such as Undaria pinnatifida (Phaeophyceae), Neopyropia yezoensis (formerly Porphyra yezoensis ) (Rhodophyta), Ulva rigida , and Ulva clathrata (formerly Enteromorpha clathrata ) have shown ACE inhibitory activity [53–57].”
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Metadata
- Authors
- Suetsuna, K., Maekawa, K., & Chen, J.-R.
- Affiliations
- National Fisheries University (JP)
- Taipei Medical University (TW)
- Corresponding author
- Chen, Jiun-Rong
- ORCID
- Chen, Jiun-Rong
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 15
- Issue
- 5
- Pages
- 267-272
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2002247285
- Cited by
- 249
- References
- 32
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 15 · 2022: 14 · 2021: 16 · 2020: 13 · 2019: 17 · 2018: 13 · 2017: 15 · 2016: 7 · 2015: 10 · 2014: 17 · 2013: 20 · 2012: 11
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Keywords
- Undaria pinnatifida, dipeptides, antihypertensive effect, angiotensin-converting enzyme inhibition, blood pressure, spontaneously hypertensive rats, hot water extract
- MeSH terms
- Amino Acid Sequence, Angiotensin-Converting Enzyme Inhibitors, Animals, Antihypertensive Agents, Blood Pressure, Dipeptides, Hypertension, Kinetics, Plant Extracts, Rats, Inbred SHR, Undaria, Rats
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