Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394

Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents

Ondetti, M. A., Rubin, B., & Cushman, D. W. (1977) · Science · doi:10.1126/science.191908 · Cited by 1,868

Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence.

Cheung, H. S., Wang, F. L., Ondetti, M. A., Sabo, E. F., & Cushman, D. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86187-2 · Cited by 746

Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom

Ferreira, S. H., Bartelt, D. C., & Greene, L. J. (1970) · Biochemistry · doi:10.1021/bi00815a005 · Cited by 515

A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects

Hata, Y., Yamamoto, M., Ohni, M., Nakajima, K., Nakamura, Y., & Takano, T. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.767 · Cited by 508

Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom

J.P. (1971) · Toxicon · doi:10.1016/0041-0101(71)90098-5 · Cited by 480

Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca

Cheung, H. S., & Cushman, D. W. (1973) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(73)90352-5 · Cited by 271

Antihypertensive Peptides Are Present in Aorta after Oral Administration of Sour Milk Containing These Peptides to Spontaneously Hypertensive Rats

Masuda, O., Nakamura, Y., & Takano, T. (1996) · Journal of Nutrition · doi:10.1093/jn/126.12.3063 · Cited by 264

Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Suetsuna, K., & Nakano, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00110-8 · Cited by 243

Identification of Antihypertensive Peptides from Peptic Digest of Two Microalgae, Chlorella vulgaris and Spirulina platensis

Suetsuna, K., & Chen, J. (2001) · Marine Biotechnology · doi:10.1007/s10126-001-0012-7 · Cited by 219

Angiotensin-I converting enzyme (ACE) inhibitory mechanism of tripeptides containing aromatic residues

Kobayashi, Y., Yamauchi, T., Katsuda, T., Yamaji, H., & Katoh, S. (2008) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.106.310 · Cited by 47

Therapeutic Potential of Seaweed-Derived Bioactive Compounds for Cardiovascular Disease Treatment

Cho, C. H., Lu, Y., Kim, M., Jeon, Y., & Lee, S. (2022) · Applied Sciences · doi:10.3390/app12031025 · Cited by 46

A complete workflow for discovering small bioactive peptides in foods by LC-MS/MS: A case study on almonds

Huang, Y.-P., Dias, F. F. G., Bell, J. M. L. N. D. M., & Barile, D. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130834 · Cited by 42

Insects as source of angiotensin converting enzyme inhibitory peptides

Cito, A., Botta, M., Francardi, V., & Dreassi, E. (2017) · Journal of Insects as Food and Feed · doi:10.3920/jiff2017.0017 · Cited by 42

Characterization of ACE Inhibitory Peptides Prepared from Pyropia pseudolinearis Protein

Kumagai, Y., Toji, K., Katsukura, S., Morikawa, R., Uji, T., Yasui, H., Shimizu, T., & Kishimura, H. (2021) · Marine Drugs · doi:10.3390/md19040200 · Cited by 42

Assay of Angiotensin I-converting Enzyme-inhibiting Activity Based on the Detection of 3-Hydroxybutyrate with Water-soluble Tetrazolium Salt

Lan, L. H., Shimamura, T., Manabe, S., Ishiyama, M., & Ukeda, H. (2008) · Analytical Sciences · doi:10.2116/analsci.24.1057 · Cited by 41

Inhibition of Angiotensin-Converting Enzyme Activity by a Partially Purified Fraction of Gynura procumbens in Spontaneously Hypertensive Rats

Hoe, S.-Z., Kamaruddin, M. Y., & Lam, S.-K. (2007) · Medical Principles and Practice · doi:10.1159/000100391 · Cited by 41

Isolation and identification of an angiotensin I-converting enzyme inhibitory peptide from pearl oyster (Pinctada fucata) shell protein hydrolysate

Sasaki, C., Tamura, S., Tohse, R., Fujita, S., Kikuchi, M., Asada, C., & Nakamura, Y. (2018) · Process Biochemistry · doi:10.1016/j.procbio.2018.11.017 · Cited by 40

Insights into the Regulation of Algal Proteins and Bioactive Peptides Using Proteomic and Transcriptomic Approaches

Beaulieu, L. (2019) · Molecules · doi:10.3390/molecules24091708 · Cited by 40

Matrix metalloproteinases (MMPs) inhibitory effects of an octameric oligopeptide isolated from abalone Haliotis discus hannai

Nguyen, V.-T., Qian, Z., Ryu, B., Kim, K., Kim, D., Kim, Y., Jeon, Y., Park, W. S., Choi, I., Kim, G., et al. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.03.038 · Cited by 39

Determination of Antihypertensive Peptides from an Izumi Shrimp Hydrolysate

Yoshitaka, N. I. I., Fukuta, K., Yoshimoto, R., Sakai, K., & Ogawa, T. (2008) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70565 · Cited by 38

Identification of ACE inhibitory peptides from red alga Mazzaella japonica

Kumagai, Y., Kitade, Y., Kobayashi, M., Watanabe, K., Kurita, H., Takeda, H., Yasui, H., & Kishimura, H. (2020) · European Food Research and Technology · doi:10.1007/s00217-020-03567-z · Cited by 37

Frequency of Seaweed Intake and Its Association with Cardiovascular Disease Mortality: The JACC Study

Kishida, R., Yamagishi, K., Muraki, I., Sata, M., Tamakoshi, A., Iso, H., & for the JACC Study Group (2020) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.53447 · Cited by 37

Potential benefits of dietary seaweeds as protection against COVID-19

Tamama, K. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa126 · Cited by 40

Exploring the health benefits and concerns of brown seaweed consumption: A comprehensive review of bioactive compounds in brown seaweed and its potential therapeutic effects

Jang, H., Lee, J., Park, Y., & Lee, J.-Y. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101215 · Cited by 40

Marine Functional Foods

Freitas, A. C., Pereira, L., Rodrigues, D., CARVALHO, A. P. F. D., Panteleitchouk, T. S. L., Gomes, A., & Duarte, A. C. (2015) · Springer eBooks · doi:10.1007/978-3-642-53971-8_42 · Cited by 36

Cardiovascular Active Peptides of Marine Origin with ACE Inhibitory Activities: Potential Role as Anti-Hypertensive Drugs and in Prevention of SARS-CoV-2 Infection

Festa, M., Sansone, C., Brunet, C., Crocetta, F., Paola, L. D., Lombardo, M., Bruno, A., Noonan, D. M., & Albini, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218364 · Cited by 36

Seaweed Proteins as a Source of Bioactive Peptides

Alboofetileh, M., Hamzeh, A., & Abdollahi, M. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210208153249 · Cited by 34

Purification and identification of an angiotensin I-converting enzyme inhibitory peptide from cauliflower by-products protein hydrolysate

Xu, Y., Bao, T., Han, W., Chen, W., Zheng, X., & Wang, J. (2016) · Process Biochemistry · doi:10.1016/j.procbio.2016.05.023 · Cited by 33

Bioactive Proteins and Peptides from Macroalgae, Fish, Shellfish and Marine Processing Waste

Harnedy, P. A., & Fitzgerald, R. J. (2013) · doi:10.1002/9781118375082.ch2 · Cited by 33

Seaweeds as a Source of Proteins for Use in Pharmaceuticals and High‐Value Applications

Okolie, C. L., Mason, B., & Critchley, A. T. (2018) · Wiley eBooks · doi:10.1002/9781119385332.ch11 · Cited by 34

Microalgae-Derived Peptides: Exploring Bioactivities and Functional Food Innovations

Ashraf, A., Guo, Y., Yang, T., ud Din, A. S., Ahmad, K., Li, W., & Hou, H. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06800 · Cited by 32

Enzymatic Hydrolysis of Water Lentil (Duckweed): An Emerging Source of Proteins for the Production of Antihypertensive Fractions

Bernier, M.-È., Thibodeau, J., & Bazinet, L. (2024) · Foods · doi:10.3390/foods13020323 · Cited by 32

Continuous microwave-assisted step-by-step extraction of bioactive water-soluble materials and fucoidan from brown seaweed Undaria pinnatifida waste

Sasaki, C., Tamura, S., Suzuki, M., Etomi, K., Nii, N., Hayashi, J., & Kanemaru, K. (2022) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-022-03035-6 · Cited by 33

Hypotensive peptides derived from plant proteins

Shobako, N. (2021) · Peptides · doi:10.1016/j.peptides.2021.170573 · Cited by 37

Angiotensin-I-Converting Enzyme Inhibitory Activity of Protein Hydrolysates Generated from the Macroalga Laminaria digitata (Hudson) JV Lamouroux 1813

Purcell, D., Packer, M. A., & Hayes, M. (2022) · Foods · doi:10.3390/foods11121792 · Cited by 30

Algal proteins, peptides and amino acids

Conde, E., Balboa, E. M., Parada, M., & Falqué, E. (2013) · Elsevier eBooks · doi:10.1533/9780857098689.1.135 · Cited by 31

Postfertilization changes in conformation of egg yolk phosvitin and biological activities of phosphopeptides

Duan, X. L., Zhou, Y., Li, M., Wu, F., Yang, N., Xu, J., Chen, H., Jin, Z., & Xu, X. (2014) · Food Research International · doi:10.1016/j.foodres.2014.05.027 · Cited by 29

A Novel LSTM-Based Machine Learning Model for Predicting the Activity of Food Protein-Derived Antihypertensive Peptides

Liao, W., Yan, S., Cao, X., Xia, H., Wang, S., Sun, G., & Cai, K. (2023) · Molecules · doi:10.3390/molecules28134901 · Cited by 29

Undaria pinnatifida extract feeding increases exercise endurance and skeletal muscle mass by promoting oxidative muscle remodeling in mice

Ahn, J., Ha, T. Y., Ahn, J., Jung, C. H., Seo, H., Kim, M. J., Kim, Y., & Jang, Y. J. (2020) · The FASEB Journal · doi:10.1096/fj.201902399rr · Cited by 27

Bioactive peptides of marine organisms: Roles in the reduction and control of cardiovascular diseases

Du, J., Xiao, M., Sudo, N., & Liu, Q. (2024) · Food Science & Nutrition · doi:10.1002/fsn3.4183 · Cited by 27

Anti-inflammatory Activity and Chemical Composition of Essential Oil Extracted with Supercritical CO2from the Brown SeaweedUndaria pinnatifida

Kang, J.-Y., Chun, B., Lee, M.-C., Choi, J., Choi, I. S., & Hong, Y. (2016) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2014.989181 · Cited by 25

Simple freezing and thawing protocol for long-term storage of harvested fresh Undaria pinnatifida

Choi, J., Lee, B.-B., An, S. J., Sohn, J. H., Cho, K. K., & Choi, I. S. (2012) · Fisheries Science · doi:10.1007/s12562-012-0529-x · Cited by 25

Identification of ace inhibitory cryptides in Tilapia protein hydrolysate by UPLC–MS/MS coupled to database analysis

Henda, Y. B., Bonnet, A., Leocádia, N. G. D. S. O., Boscolo, W. R., Fruitier‐Arnaudin, I., Bridiau, N., Maugard, T., Piot, J., Sannier, F., & Bordenave-Juchereau, S. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.02.015 · Cited by 25

Purification, Identification, and In Vivo Activity of Angiotensin I‐Converting Enzyme Inhibitory Peptide, from Ribbonfish ( Trichiurus haumela ) Backbone

Zou, P., Wang, J., He, G., & Wu, J. (2013) · Journal of Food Science · doi:10.1111/1750-3841.12269 · Cited by 24

Bioactive Substances from Marine Fishes, Shrimps, and Algae and Their Functions: Present and Future

Yu, P., & Gu, H. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.686933 · Cited by 24

Structural characteristics of phycobiliproteins from red alga Mazzaella japonica

Kitade, Y., Miyabe, Y., Yamamoto, Y. Y., Takeda, H., Shimizu, T., Yasui, H., & Kishimura, H. (2017) · Journal of Food Biochemistry · doi:10.1111/jfbc.12436 · Cited by 24

Emerging potentials of duckweed (Lemnaceae): From composition to protein uses in food and nutraceuticals – A review

Muller, T., Cournoyer, A., & Bazinet, L. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116777 · Cited by 26

Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome

Rico, D., Martín‐Diana, A. B., Milton‐Laskibar, I., Fernández‐Quintela, A., Silván, J. M., Rai, D. K., Choudhary, A. N., Peñas, E., de Luis, D. A., & Martínez‐Villaluenga, C. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.010 · Cited by 24

Affinity Purification of Angiotensin Converting Enzyme Inhibitory Peptides from Wakame (Undaria Pinnatifida) Using Immobilized ACE on Magnetic Metal Organic Frameworks

Feng, X., Liao, D., Sun, L., Wu, S., Lan, P., Wang, Z., Li, C., Zhou, Q., Lu, Y., & Lan, X. (2021) · Marine Drugs · doi:10.3390/md19030177 · Cited by 23

Machine learning-driven discovery of bioactive peptides from duckweed (Lemnaceae) protein hydrolysates: Identification and experimental validation of 20 novel antihypertensive, antidiabetic, and/or antioxidant peptides

Cournoyer, A., Bernier, M.-È., Aboubacar, H., de Toro‐Martín, J., Vohl, M., Ravallec, R., Cudennec, B., & Bazinet, L. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144029 · Cited by 24

Seaweed Intake and Risk of Cardiovascular Disease: The Circulatory Risk in Communities Study (CIRCS)

Chichibu, H., Yamagishi, K., Kishida, R., Maruyama, K., Hayama‐Terada, M., Shimizu, Y., Muraki, I., Umesawa, M., Cui, R., Imano, H., et al. (2021) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.61390 · Cited by 22

Characterization of β-secretase inhibitory peptide purified from skate skin protein hydrolysate

Lee, J. K., Li‐Chan, E. C. Y., & Byun, H. (2014) · European Food Research and Technology · doi:10.1007/s00217-014-2314-9 · Cited by 22

Anti-Edema Effects of Brown Seaweed (Undaria pinnatifida) Extract on Phorbol 12-Myristate 13-Acetate-Induced Mouse Ear Inflammation

Khan, M. N. A., Yoon, S.-J., Choi, J., Park, N. G., Lee, H. H., Cho, J., & Hong, Y. (2009) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x09006837 · Cited by 22

Protective Effect of Pyropia yezoensis Peptide on Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes

Lee, M., Choi, J., Choi, Y., & Nam, T. (2019) · Marine Drugs · doi:10.3390/md17050284 · Cited by 22

Production of Bioactive Peptides from Microalgae and Their Biological Properties Related to Cardiovascular Disease

Fernando, R. C., Sun, X., & Rupasinghe, H. P. V. (2024) · Macromol—A Journal of Macromolecular Research · doi:10.3390/macromol4030035 · Cited by 22

Bioaccessibility, digestibility and nutritional properties of algae and Cyanophyceae as basis of their potential as functional food ingredients

Peñalver, R., Lorenzo, J. M., & Nieto, G. (2024) · Applied Food Research · doi:10.1016/j.afres.2024.100404 · Cited by 21

Amino-Acid Composition of Arctic Brown Algae

Боголицын, К. Г., Александрович, К. П., & Pochtovalova, A. S. (2014) · Chemistry of Natural Compounds · doi:10.1007/s10600-014-0831-1 · Cited by 21

Development Of Functional Foods: Sea Weeds (Algae) Untouched Potential And Alternative Resource - A Review

Admassu, H., Wei, Z., Yang, R., Gasmalla, M. A. A., & Alsir, E. (2015) · International journal of scientific and technology research · Cited by 22

Undaria pinnatifida (Wakame): A Seaweed with Pharmacological Properties

Zhang, H., Pang, Z., & Han, C. (2014) · Science International · doi:10.17311/sciintl.2014.32.36 · Cited by 21

Discovery of Novel Angiotensin-Converting Enzyme Inhibitory Peptides from Todarodes pacificus and Their Inhibitory Mechanism: In Silico and In Vitro Studies

Yu, D., Wang, C., Song, Y., Zhu, J., & Zhang, X. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174159 · Cited by 21

Radical Scavenging Potential of Hydrophilic Phlorotannins of Hizikia fusiformis

Siriwardhana, N., Lee, K.-W., & Jeon, Y. (2005) · ALGAE · doi:10.4490/algae.2005.20.1.069 · Cited by 21

Computational design of Phe-Tyr dipeptide and preparation, characterization, cytotoxicity studies of Phe-Tyr dipeptide loaded PLGA nanoparticles for the treatment of hypertension

Kecel‐Gunduz, S., Budama‐Kilinc, Y., Çakır-Koç, R., Kökcü, Y., Bıçak, B., Aslan, B., & Özel, A. E. (2017) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2017.1371644 · Cited by 20

Algal proteins for sustainable nutrition and functional food innovation

Saeed, F., Tul Zohra, K., Naveed, K., Zia, A., Khaliq, M., Noor, Z., Khaliq, K., & Ali, M. A. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.100752 · Cited by 19

Effects of the brown seaweed Undaria pinnatifida on erythematous inflammation assessed using digital photo analysis

Khan, M. N. A., Lee, M., Kang, J., Park, N. G., Fujii, H., & Hong, Y. (2008) · Phytotherapy Research · doi:10.1002/ptr.2349 · Cited by 19

Seaweeds-derived proteins and peptides: preparation, virtual screening, health-promoting effects, and industry applications

Wang, L., Wang, L., Liu, X., Lin, X., Tao, F., & Zhang, W. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2449596 · Cited by 20

First Report of Screening of Novel Angiotensin-I Converting Enzyme Inhibitory Peptides Derived from the Red Alga Acrochaetium sp.

Windarto, S., Lee, M., Nursyam, H., & Hsu, J. (2022) · Marine Biotechnology · doi:10.1007/s10126-022-10152-w · Cited by 20

Application of a Combined Peptidomics and In Silico Approach for the Identification of Novel Dipeptidyl Peptidase-IV-Inhibitory Peptides in In Vitro Digested Pinto Bean Protein Extract

Martini, S., Cattivelli, A., Conte, A., & Tagliazucchi, D. (2021) · Current Issues in Molecular Biology · doi:10.3390/cimb44010011 · Cited by 18

Marine Edible Algae as Disease Preventers

Gómez-Gutiérrez, C. M., Guerra‐Rivas, G., Soria-Mercado, I. E., & Ayala-Sánchez, N. E. (2011) · Advances in food and nutrition research · doi:10.1016/b978-0-12-387669-0.00003-x · Cited by 17

Isolation and characterization of a new potential source of bioactive peptides: White mulberry (Morus alba) fruits and its leaves

Demirel, F. T. K., Şahingil, D., & Hayaloğlu, A. A. (2023) · Food Chemistry Advances · doi:10.1016/j.focha.2023.100597 · Cited by 16

Transepithelial Transport and Stability in Blood Serum of Angiotensin-I-Converting Enzyme Inhibitory Dipeptides

Pentzien, A.-K., & Meisel, H. (2008) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2008-5-623 · Cited by 16

Anti-obesity and anti-diabetic activities of algae

Maeda, H. (2013) · Elsevier eBooks · doi:10.1533/9780857098689.2.453 · Cited by 16

Optimization of acid hydrolysis conditions of delimed tannery fleshings by response surface method

Kumar, A., Nived, C., Sakhare, P. Z., Suresh, P. V., Bhaskar, N., & Mahendrakar, N. S. (2009) · CFTRI Institutional Repository · Cited by 16

Melanogenesis inhibitory activity of Korean Undaria pinnatifida in mouse B16 melanoma cells

Kim, M., Kim, D. S., Yoon, H.-S., Lee, W. J., Lee, N. H., & Hyun, C. (2014) · Interdisciplinary Toxicology · doi:10.2478/intox-2014-0012 · Cited by 15

Antihypertensive Peptides from Marine Sources

Norris, R., Harnedy, P. A., & Fitzgerald, R. J. (2013) · doi:10.1002/9781118412893.ch2 · Cited by 15

A peptide fraction from hardened common beans (Phaseolus vulgaris) induces endothelium-dependent antihypertensive and renal effects in rats

Ribeiro, J. V. V., Graziani, D., Carvalho, J. H., Mendonça, M. M., Naves, L. M., Oliveira, H. F., Campos, H. M., Fíoravantí, M. C. S., Pacheco, L. F., Ferreira, P. M., et al. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.100410 · Cited by 14

Pharmacoinformatics and cellular studies of algal peptides as functional molecules to modulate type-2 diabetes markers

Kurniawan, R., Taslim, N. A., Hardinsyah, H., Syauki, A. Y., Idris, I., Aman, A. M., Permatasari, H. K., Wiyarta, E., Surya, R., Mayulu, N., et al. (2024) · Future Foods · doi:10.1016/j.fufo.2024.100354 · Cited by 14

Seaweeds: Valuable Ingredients for the Pharmaceutical Industries

Siahaan, E. A., Pangestuti, R., & Kim, S. (2018) · Grand challenges in biology and biotechnology · doi:10.1007/978-3-319-69075-9_2 · Cited by 17

Oligopeptides hydrolysed by muscle dipeptidyl peptidases can generate angiotensin-I converting enzyme inhibitory dipeptides

Sentandreu, M. Á., & Toldrá, F. (2006) · European Food Research and Technology · doi:10.1007/s00217-006-0367-0 · Cited by 14

Food-derived Trp-rich oligopeptides: Production, bioactivities, and structure-function relationship

Wu, J., Cui, C., & Sun‐Waterhouse, D. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.104247 · Cited by 14

Oligopeptides hydrolysed by muscle dipeptidyl peptidases can generate angiotensin-I converting enzyme inhibitory dipeptides

Sentandreu, M. Á., & Toldrá, F. (2006) · European Food Research and Technology · doi:10.1007/s00217-006-0451-5 · Cited by 13

Antioxidant Activity and Amino Acid Profiling of Protein Hydrolysates from the Skin ofSphyraena barracudaandLepturacanthus savala

Nazeer, R. A., & Deeptha, R. (2013) · International Journal of Food Properties · doi:10.1080/10942912.2011.553757 · Cited by 13

Biologically Active Peptides from Foods

Shahidi, F., & Li, Q. (2014) · Wiley eBooks · doi:10.1002/9781118860588.ch6 · Cited by 13

Biological Activities of Proteins and Marine‐derived Peptides from Byproducts and Seaweeds

Hayes, M. (2013) · Wiley eBooks · doi:10.1002/9781118375082.ch7 · Cited by 13

Bioactive dipeptides mitigate high-fat and high-fructose corn syrup diet-induced metabolic-associated fatty liver disease via upregulation of Nrf2/HO-1 expressions in C57BL/6J mice

Wayal, V., & Hsieh, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115724 · Cited by 14

Production and characterisation of PHAs by pure culture using protein hydrolysates as sole carbon source

Critelli, P., Pesante, G., Lupinelli, S., Modesti, M., Zanatta, S., Battısta, F., Bolzonella, D., & Frison, N. (2022) · Environmental Technology & Innovation · doi:10.1016/j.eti.2022.102919 · Cited by 12

Undaria pinnatifida a Rich Marine Reservoir of Nutritional and Pharmacological Potential: Insights into Growth Signaling and Apoptosis Mechanisms in Cancer

Phull, A. R., & Kim, S. J. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1490449 · Cited by 13

Nutritional Composition and Biological Activities of the Methanol Extracts of Sea Mustard (Undaria pinnatifida) in Market.

Choi, J., Bae, H.-J., Kim, Y.-C., Park, N.-H., Kim, T.-B., Choi, Y., Choi, E., Park, S., & Choi, I.-S. (2008) · Journal of Life Science · doi:10.5352/jls.2008.18.3.387 · Cited by 12

Algae and cardiovascular health

Sánchez-Muniz, F. J., de Juana, A. B., Bastida, S., & Benedı́, J. (2013) · Elsevier eBooks · doi:10.1533/9780857098689.2.369 · Cited by 10

Nutritional profile and in vitro immunomodulatory activity of protein extract from goat placenta and fermented extraction residual

Hou, Y., Yang, S., Huang, J., Xu, Q., Liao, A., Zhong, Q., & Li, M. (2020) · Journal of Food Process Engineering · doi:10.1111/jfpe.13576 · Cited by 10

Bioactive Metabolites and Value-Added Products from Marine Macroalgae

Rengasamy, K. R. R., Kulkarni, M. G., Stirk, W. A., & Staden, J. V. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9590-1_21 · Cited by 10

Role of alginate in the mechanism by which brown seaweed Saccharina japonica intake alleviates an increase in blood pressure in 2-kidney, 1-clip renovascular hypertensive rats

Maruyama, S., Segawa, Y., Hashimoto, H., Kitamura, S., Kimura, M., Osera, T., & Kurihara, N. (2021) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2021.1991943 · Cited by 9

In Silico and In Vitro Analyses of Angiotensin-I Converting Enzyme Inhibitory and Antioxidant Activities of Enzymatic Protein Hydrolysates from Taiwan Mackerel (Scomber australasicus) Steaming Juice

Panjaitan, F. C. A., Chen, T.-Y., Ku, H., & Chang, Y. (2022) · Foods · doi:10.3390/foods11121785 · Cited by 9

Peptides fonctionnels marins

Bouglé, D. L. (2007) · Phytothérapie · doi:10.1007/s10298-007-0230-x · Cited by 9

Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Wheat Bran in Spontaneously Hypertensive Rats

Nogata, Y., Nagamine, T., & Sekiya, K. (2011) · NIPPON SHOKUHIN KOGYO GAKKAISHI · doi:10.3136/nskkk.58.67 · Cited by 9

The potential of protein hydrolysates from marine by-products: Mechanisms, health benefits, applications, future prospects, and challenges

Gan, M. Q., Poh, J. M., Lim, S. J., & Chang, L. S. (2024) · Process Biochemistry · doi:10.1016/j.procbio.2024.10.008 · Cited by 10

An ethanol extract from the phaeophyte Undaria pinnatifida improves learning and memory impairment and dendritic spine morphology in hippocampal neurons

Choi, J.-Y., Mohibbullah, M., Park, I.-S., Moon, I. S., & Hong, Y. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-017-1116-4 · Cited by 8

Marine Bioactive Peptide Sources: Critical Points and the Potential for New Therapeutics

Pangestuti, R., & Kim, S. (2013) · doi:10.1002/9781118375082.ch28 · Cited by 8

Anti-inflammatory Activity of the Undaria pinnatifida Water Extract

Jeong, D.-H., Kim, K.-B.-W.-R., Kang, B., Jung, S.-A., Kim, H., Jeong, H.-Y., Bark, S.-W., & Ahn, D.-H. (2012) · Journal of Applied Biological Chemistry · doi:10.3839/jabc.2012.035 · Cited by 7

Preparation of Yeast Hydrolysate Enriched in Cyclo-His-Pro (CHP) by Enzymatic Hydrolysis and Evaluation of Its Functionality

Lee, H. J., Son, H. S., Park, C., & Suh, H. J. (2015) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2015.20.4.284 · Cited by 7

Applications of Spent Biomass

Guedes, A. C., Amaro, H. M., Sousa‐Pinto, I., & Malcata, F. X. (2013) · Elsevier eBooks · doi:10.1016/b978-0-444-59558-4.00010-3 · Cited by 8

Sustainable, alternative sources of bioactive peptides

Aguilar-Toalá, J. E., Hall, F. G., Urbizo-Reyes, U., & Liceaga, A. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821389-6.00004-2 · Cited by 7

Secret heroes of the sea: brown macroalgae and their bioactive powers—a narrative review

Başak, C. A. N., & Şanlıer, N. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1766041 · Cited by 6

Upgrading of Sea By-products

Cudennec, B., Caradec, T., Catiau, L., & Ravallec, R. (2012) · Advances in food and nutrition research · doi:10.1016/b978-0-12-416003-3.00031-7 · Cited by 6

Enzymatic protein hydrolysates, and ultrafiltered peptide fractions from two molluscs: Tympanotonus fuscatus var. radula (L.) and Pachymelania aurita (M.), with angiotensin-I-converting enzyme inhibitory and DPPH radical scavenging activities

Osoniyi, O. R., Paul, A. A., Eghianruwa, Q., Oparinde, O. G., & Adesina, A. S. (2021) · International Journal of Applied and Basic Medical Research · doi:10.4103/ijabmr.ijabmr_375_19 · Cited by 6

[Dedicated to Prof. T. Okada and Prof. T. Nishioka: data science in chemistry]Analysis of Water-soluble Constituents in Fermented Brown Rice and Rice Bran by Aspergillus oryzae (FBRA)

Tanaka, K., Horie, Y., Nemoto, H., Kosaka, H., Jo, M., & Tezuka, Y. (2017) · Journal of Computer Aided Chemistry · doi:10.2751/jcac.18.46 · Cited by 6

Undaria pinnatifida (Wakame) Intake Ameliorates High-Fat Diet-Induced Glucose Intolerance via Promoting GLUT4 Expression and Membrane Translocation in Muscle

Imai, M., Kawakami, F., Chiba, M., Kanzaki, M., & Maruyama, H. (2023) · Journal of Nutrition and Metabolism · doi:10.1155/2023/9774157 · Cited by 6

Marine Microalgae in Food and Health Applications

Pangestuti, R., Noerdjito, D. R., Siahaan, E. A., Sapulete, S., & Kim, S. (2020) · Encyclopedia of Marine Biotechnology · doi:10.1002/9781119143802.ch14 · Cited by 6

Flow injection analysis of angiotensin I-converting enzyme inhibitory activity with enzymatic reactors

Lan, L. H., Shimamura, T., Ishiyama, M., & Ukeda, H. (2009) · Talanta · doi:10.1016/j.talanta.2009.02.016 · Cited by 5

The Half Maximal Inhibitory Concentration (IC50) Effect of Protein Hydrolysates from Rainbow Trout (Oncorhynchus mykiss) Skin on Enterotoxin A Gene Expression in Staphylococcus aureus

Yaghoubzadeh, Z., Kaboosi, H., Ghadikolaii, F. P., Safari, R., & Fattahi, E. (2020) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-020-10036-4 · Cited by 5

わかめペプチドによる高血圧自然発症ラットの血圧降下作用

Suetsuna, K., Maekawa, K., & Chen, J.-R. (2003) · Institutional Repositories DataBase (IRDB)

Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida)

Suetsuna, K., & Nakano, T. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00110-8 · Cited by 243

Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Wakame (Undaria pinnatifida) and Their Antihypertensive Effect in Spontaneously Hypertensive Rats

Sato, M., Hosokawa, T., Yamaguchi, T., Nakano, T., Muramoto, K., Kahara, T., Funayama, K., Kobayashi, A., & Nakano, T. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020482t · Cited by 290

Antihypertensive Effects of Hydrolysates of Wakame (Undaria pinnatifida) and Their Angiotensin-I-Converting Enzyme Inhibitory Activity

Sato, M., Oba, T., Yamaguchi, T., Nakano, T., Kahara, T., Funayama, K., Kobayashi, A., & Nakano, T. (2002) · Annals of Nutrition and Metabolism · doi:10.1159/000066495 · Cited by 63

Acute effect of whey peptides upon blood pressure of hypertensive rats, and relationship with their angiotensin‐converting enzyme inhibitory activity

Tavares, T. G., Sevilla, M. A., Montero, M. J., Carrón, R., & Malcata, F. X. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100381 · Cited by 58