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Cited by 420

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease

Open access
Ansari, Mubeen Ahmad, Abdul, Hafiz Mohammad, Joshi, Gururaj, Opii, Wycliffe O., Butterfield, D. Allan·2009·The Journal of Nutritional Biochemistry
DOI 10.1016/j.jnutbio.2008.03.002
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Abstract

Quercetin, a flavonoid found in various foodstuffs, has antioxidant properties, increases glutathione (GSH) levels and antioxidant enzyme function. Considerable attention has been focused on increasing the intracellular GSH levels in many diseases, including Alzheimer's disease (AD). Amyloid beta-peptide [Abeta(1-42)], elevated in AD brain, is associated with oxidative stress and neurotoxicity. The present study was aimed to investigate the protective effects of quercetin on Abeta(1-42)-induced oxidative cell toxicity in cultured neurons. Decreased cell survival in neuronal cultures treated with Abeta(1-42) correlated with increased free radical production measured by dichlorofluorescein fluorescence and an increase in protein oxidation (protein carbonyl, 3-nitrotyrosine) and lipid peroxidation (protein bound 4-hydroxy-2-nonenal). Pretreatment of primary hippocampal cultures with quercetin significantly attenuated Abeta(1-42)-induced cytotoxicity, protein oxidation, lipid peroxidation and apoptosis. A dose-response study suggested that quercetin showed protective effects against Abeta(1-42) toxicity by modulating oxidative stress at lower doses, but higher doses not only were non-neuroprotective, but were toxic. These findings provide motivation to test the hypothesis, that quercetin may provide a promising approach for the treatment of AD and other oxidative stress-related neurodegenerative diseases.

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Metadata

Authors
Ansari, M. A., Abdul, H. M., Joshi, G., Opii, W. O., & Butterfield, D. A.
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
2009-04
Volume
20
Issue
4
Pages
269-275
ISSN
0955-2863 (ISSN-L)
DOI
10.1016/j.jnutbio.2008.03.002
OpenAlex
W2168190728
Cited by
420
References
51
FWCI
6.43
Type
journal article
Language
en
Open access
green

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The paper
Ansari, M. A., Abdul, H. M., Joshi, G., Opii, W. O., & Butterfield, D. A. (2009). Protective effect of quercetin in primary neurons against Aβ(1–42): relevance to Alzheimer's disease. The Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2008.03.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.