The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Structural, Chemical and Biological Aspects of Antioxidants for Strategies Against Metal and Metalloid Exposure
Open accessAbstract
Oxidative stress contributes to the pathophysiology of exposure to heavy metals/metalloid. Beneficial renal effects of some medications, such as chelation therapy depend at least partially on the ability to alleviate oxidative stress. The administration of various natural or synthetic antioxidants has been shown to be of benefit in the prevention and attenuation of metal induced biochemical alterations. These include vitamins, N‐acetylcysteine, α‐lipoic acid, melatonin, dietary flavonoids and many others. Human studies are limited in this regard. Under certain conditions, surprisingly, the antioxidant supplements may exhibit pro‐oxidant properties and even worsen metal induced toxic damage. To date, the evidence is insufficient to recommend antioxidant supplements in subject with exposure to metals. Prospective, controlled clinical trials on safety and effectiveness of different therapeutic antioxidant strategies either individually or in combination with chelating agent are indispensable. The present review focuses on structural, chemical and biological aspects of antioxidants particularly related to their chelating properties.
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Kurutas, E. B. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0186-5 · Cited by 2,152
Carocho, M., & Ferreira, I. C. F. R. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.09.021 · Cited by 1,661
A review on detection of heavy metal ions in water—An electrochemical approach
Gumpu, M. B., Sethuraman, S., Krishnan, U. M., & Rayappan, J. B. B. (2015) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2015.02.122 · Cited by 1,027
Heavy Metal Stress and Some Mechanisms of Plant Defense Response
Emamverdian, A., Ding, Y., Mokhberdoran, F., & Xie, Y. (2015) · The Scientific World Journal · doi:10.1155/2015/756120 · Cited by 917
Cerium Oxide Nanoparticles: Applications and Prospects in Nanomedicine
Das, S., Dowding, J. M., Klump, K. E., McGinnis, J. F., Self, W., & Seal, S. (2013) · Nanomedicine · doi:10.2217/nnm.13.133 · Cited by 561
Metadata
- Authors
- Flora, S. J. S.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 2
- Issue
- 4
- Pages
- 191-206
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W2075103663
- Cited by
- 616
- References
- 189
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Flora, S. J. S. (2009). Structural, Chemical and Biological Aspects of Antioxidants for Strategies Against Metal and Metalloid Exposure. Oxidative Medicine and Cellular Longevity. https://doi.org/10.4161/oxim.2.4.9112
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
