The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation
Open accessAbstract
DNA methylation is the most extensively studied mechanism of epigenetic gene regulation. Increasing evidence indicates DNA methylation is labile in response to nutritional and environmental influences. Alternations in DNA methylation profiles can lead to changes in gene expression, resulting in diverse phenotypes with the potential for increased disease risk. The primary methyl donor for DNA methylation is S-adenosylmethionine (SAM), a species generated in the cyclical cellular process called one-carbon metabolism. One-carbon metabolism is catalyzed by several enzymes in the presence of dietary micronutrients, including folate, choline, betaine, and other B vitamins. For this reason, nutrition status, particularly micronutrient intake, has been a focal point when investigating epigenetic mechanisms. Though animal evidence linking nutrition and DNA methylation is fairly extensive, epidemiological evidence is less comprehensive. This review serves to integrate studies of the animal in vivo with human epidemiological data pertaining to nutritional regulation of DNA methylation, and to further identify areas in which current knowledge is limited.
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1 retracted
In utero supplementation with methyl donors enhances allergic airway disease in mice
Hollingsworth, J. W., Maruoka, S., Boon, K., Garantziotis, S., Li, Z., Tomfohr, J., Bailey, N., Potts, E. N., Whitehead, G., Brass, D. M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34378 · Cited by 331
RetractedEpigenetic differences arise during the lifetime of monozygotic twins
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
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CpG islands and the regulation of transcription
Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187
Epigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
Transposable elements: targets for early nutritional effects on epigenetic gene regulation
Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019 · cited 1×
“A methyl donor-supplemented maternal diet shifted the distribution of coat color phenotype towards brown in comparison to unsupplemented mothers [24].”
Chromatin modification and epigenetic reprogramming in mammalian development
Li, E. (2002) · Nature Reviews Genetics · doi:10.1038/nrg887 · Cited by 1,900
The Developmental Origins of Adult Disease
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Conserved role of intragenic DNA methylation in regulating alternative promoters
Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743
Phenotypic plasticity and the epigenetics of human disease
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The gut microbiota and healthy aging: A mini-review
Kim, S., & Jazwinski, S. M. (2018) · Gerontology · doi:10.1159/000490615 · Cited by 427
Clare, C. E., Brassington, A. H., Kwong, W. Y., & Sinclair, K. D. (2019) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-020518-115206 · Cited by 394
Tarrade, A., Panchenko, P., Junien, C., & Gabory, A. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110320 · Cited by 251
Epigenetic Research in Neuropsychiatric Disorders: the “Tissue Issue”
Bakulski, K. M., Halladay, A., Hu, V. W., Mill, J., & Fallin, M. D. (2016) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-016-0083-4 · Cited by 127
Epigenetics in eating disorders: a systematic review
Hübel, C., Marzi, S. J., Breen, G., & Bulik, C. M. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0254-7 · Cited by 116
Metadata
- Authors
- Anderson, O. S., Sant, K. E., & Dolinoy, D. C.
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 23
- Issue
- 8
- Pages
- 853-859
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W1979638914
- Cited by
- 767
- References
- 63
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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