EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9
Abstract
Epigallocatechin-3-gallate (EGCG), the bioactive polyphenol in green tea, has been demonstrated to have various biological activities. Our study aims to investigate the antiproliferation and antimigration effects of EGCG against bladder cancer SW780 cells both in vitro and in vivo. Our results showed that treatment of EGCG resulted in significant inhibition of cell proliferation by induction of apoptosis, without obvious toxicity to normal bladder epithelium SV-HUC-1 cells. EGCG also inhibited SW780 cell migration and invasion at 25-100 μM. Western blot confirmed that EGCG induced apoptosis in SW780 cells by activation of caspases-8, -9 and -3, Bax, Bcl-2 and PARP. Besides, animal study demonstrated that EGCG [100 mg/kg, intraperitoneal (i.p.) injection daily for 3 weeks] decreased the tumor volume significantly in mice bearing SW780 tumors, as well as the tumor weight (decreased by 68.4%). In addition, EGCG down-regulated the expression of nuclear factor-kappa B (NF-κB) and matrix metalloproteinase (MMP)-9 in both protein and mRNA level in tumor and SW780 cells. When NF-κB was inhibited, EGCG showed no obvious effect in cell proliferation and migration. In conclusion, our study demonstrated that EGCG was effective in inhibition SW780 cell proliferation and migration, and presented first evidence that EGCG inhibited SW780 tumor growth by down-regulation of NF-κB and MMP-9.
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EGCG inhibits the initiation, promotion, and progression of different types of tumors in vitro and in vivo.
“Numerous studies, both in vitro using various cancer cell lines and in vivo in animal models, have consistently demonstrated the ability of EGCG to inhibit the initiation, promotion, and progression of different types of tumors.141–145”
From Drug repurposing for cancer therapy (2024) · cites this paper as [143]
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- Authors
- Luo, K.-W., Chen, W., Lung, W.-Y., Wei, X.-Y., Cheng, B.-H., Cai, Z.-M., & Huang, W.-R.
- Affiliations
- Shenzhen University (CN)
- Longgang Central Hospital (CN)
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2017-03
- Volume
- 41
- Pages
- 56-64
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2564590940
- Cited by
- 137
- References
- 38
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 13 · 2023: 12 · 2022: 20 · 2021: 15 · 2020: 24 · 2019: 23 · 2018: 8 · 2017: 5
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Update notices
- erratum (2024-01-01)
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Basic Research Program of China (2014CB745201)
- Chinese High-Tech (863) Program (2014AA020607)
- NSFC program (81403160)
- Guangdong Province Bureau of Traditional Chinese Medicine Program of China (20162121)
- China Postdoctoral fund (2016 M590841)
- Shenzhen Innovation of Science and Technology Commission
- Shenzhen Municipal Science and Technology Program of China (ZDSYS201506050935272, JCYJ20160425103000011)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Surgery › Bladder and Urothelial Cancer Treatments
- Keywords
- epigallocatechin gallate, bladder cancer, apoptosis, cell migration, tumor invasion, NF-κB, MMP-9, caspase activation, green tea polyphenols, anticancer activity, tumor growth inhibition
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Urinary Bladder, Urinary Bladder Neoplasms, Catechin, Dose-Response Relationship, Drug, Female, Humans, Injections, Intraperitoneal, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness, Neoplasm Proteins, Random Allocation, Specific Pathogen-Free Organisms, Down-Regulation, NF-kappa B, Apoptosis, Matrix Metalloproteinase 9, Xenograft Model Antitumor Assays, Cell Line, Tumor, Tumor Burden
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