Strategies for MMP inhibition in cancer: innovations for the post-trial era

New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108 · see citing works

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

Coussens, L. M., Fingleton, B., & Matrisian, L. M. (2002) · Science · doi:10.1126/science.1067100 · Cited by 2,761 · see citing works

A matrix metalloproteinase expressed on the surface of invasive tumour cells

Sato, H., Takino, T., Okada, Y., Cao, J. P., Shinagawa, A., Yamamoto, E., & Seiki, M. (1994) · Nature · doi:10.1038/370061a0 · Cited by 2,534 · see citing works

Putting tumours in context

Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works

Tissue inhibitors of metalloproteinases: evolution, structure and function

Brew, K., Dinakarpandian, D., & Nagase, H. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(99)00279-4 · Cited by 1,915 · see citing works

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

Liotta, L. A., Tryggvason, K., Garbisa, S., Hart, I. R., Foltz, C. M., & Shafie, S. M. (1980) · Nature · doi:10.1038/284067a0 · Cited by 1,768 · see citing works

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

Strongin, A. Y., Collier, I. E., Bannikov, G. A., Marmer, B. L., Grant, G. A., & Goldberg, G. I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5331 · Cited by 1,589 · see citing works

Regulation of matrix metalloproteinase expression in tumor invasion

Westermarck, J. K., & Kähäri, V. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.8.781 · Cited by 1,494 · see citing works

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

Adams, J., Palombella, V. J., Sausville, E. A., Johnson, J. I., Destree, A. T., Lazarus, D. D., Maas, J., Pien, C. S., Prakash, S., & Elliott, P. J. (1999) · PubMed · Cited by 1,457 · see citing works

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

Gross, J., & Lapiere, C. M. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.6.1014 · Cited by 1,314 · see citing works

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Gehron Robey, P., Poole, A. R., Pidoux, I., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80064-1 · Cited by 1,298 · see citing works

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

Basset, P., Bellocq, J., Wolf, C., Stoll, I., Hutin, P., Limacher, J. M., Podhajcer, O. L., Chenard, M., Rio, M., & Chambon, P. (1990) · Nature · doi:10.1038/348699a0 · Cited by 1,125 · see citing works

Matrix metalloproteinases: a tail of a frog that became a prince

Brinckerhoff, C., & Matrisian, L. M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm763 · Cited by 1,098 · see citing works

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

Sternlicht, M. D., Lochter, A., Sympson, C. J., Huey, B., Rougier, J., Gray, J. W., Pinkel, D., Bissell, M. J., & Werb, Z. (1999) · Cell · doi:10.1016/s0092-8674(00)81009-0 · Cited by 924 · see citing works

Development of Matrix Metalloproteinase Inhibitors in Cancer Therapy

Hidalgo, M. M., & Eckhardt, S. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.3.178 · Cited by 802 · see citing works

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

McQuibban, G. A., Gong, J.-H., Tam, E. M., McCulloch, C. A., Clark‐Lewis, I., & Overall, C. M. (2000) · Science · doi:10.1126/science.289.5482.1202 · Cited by 772 · see citing works

Protease degradomics: A new challenge for proteomics

López-Otı́n, C., & Overall, C. M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm858 · Cited by 748 · see citing works

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

Knäuper, V., Will, H., López-Otı́n, C., Smith, B., Atkinson, S. J., Stanton, H., Hembry, R. M., & Murphy, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17124 · Cited by 747 · see citing works

The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

Oh, J., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R. M., Nishimura, S., Imamura, Y., Kitayama, H., Alexander, D. B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00597-9 · Cited by 728 · see citing works

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

Springman, E. B., Angleton, E. L., Birkedal‐Hansen, H., & Wart, H. E. V. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.364 · Cited by 713 · see citing works

Scaling down imaging: molecular mapping of cancer in mice

Weissleder, R. (2002) · Nature reviews. Cancer · doi:10.1038/nrc701 · Cited by 709 · see citing works

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

Noë, V., Fingleton, B., Jacobs, K., Crawford, H. C., Vermeulen, S. J. T., Steelant, W. F. A., Bruyneel, E. A., Matrisian, L. M., & Mareel, M. M. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.1.111 · Cited by 697 · see citing works

The proprotein convertases

Steiner, D. F. (1998) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(98)80033-1 · Cited by 650 · see citing works

Independent Regulation of Collagenase, 72-kDa Progelatinase, and Metalloendoproteinase Inhibitor Expression in Human Fibroblasts by Transforming Growth Factor-β

Overall, C. M., Wrana, J. L., & Sodek, J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94267-5 · Cited by 636 · see citing works

Furin-dependent intracellular activation of the human stromelysin-3 zymogen

Pei, D., & Weiss, S. J. (1995) · Nature · doi:10.1038/375244a0 · Cited by 629 · see citing works

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.

Gomis-R¨th, F.-X., Maskos, K., Betz, M., Bergner, A., Huber, R., Suzuki, K., Yoshida, N., Nagase, H., Brew, K., Bourenkov, G. P., et al. (1997) · Nature · doi:10.1038/37995 · Cited by 619 · see citing works

Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases.

Boissier, S., Ferreras, M., Peyruchaud, O., Magnetto, S., Ebetino, F. H., Colombel, M. C., Delmas, P. D., Delaissé, J., & Clézardin, P. (2000) · PubMed · Cited by 573 · see citing works

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

Butler, G. S., Butler, M. J., Atkinson, S. J., Will, H., Tamura, T., van Westrum, S. M. S., Crabbe, T., Clements, J. M., d’Ortho, M., & Murphy, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.2.871 · Cited by 573 · see citing works

Tumor targeting with a selective gelatinase inhibitor

Koivunen, E., Arap, W., Valtanen, H., Rainisalo, A., Medina, O. P., Heikkilä, P., Kantor, C., Gahmberg, C. G., Salo, T. A., Konttinen, Y. T., et al. (1999) · Nature Biotechnology · doi:10.1038/11703 · Cited by 567 · see citing works

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

Turk, B. E., Huang, L. L., Piro, E. T., & Cantley, L. C. (2001) · Nature Biotechnology · doi:10.1038/90273 · Cited by 560 · see citing works

A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer

Bramhall, S. R., Schulz, J., Nemunaitis, J. J., Brown, P. D. N., Baillet, M., & BUCKELS, J. A. C. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600446 · Cited by 557 · see citing works

Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

Zucker, S., Cao, J. P., & Chen, W. (2000) · Oncogene · doi:10.1038/sj.onc.1204097 · Cited by 551 · see citing works

Structure of Human Pro-Matrix Metalloproteinase-2: Activation Mechanism Revealed

Morgunova, E. Y., Tuuttila, A., Bergmann, U., Isupov, M. N., Lindqvist, Y., Schneider, G., & Tryggvason, K. (1999) · Science · doi:10.1126/science.284.5420.1667 · Cited by 543 · see citing works

A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription.

Rutter, J. L., Mitchell, T. I., Butticè, G., et al. (1998) · PubMed · Cited by 533 · see citing works

TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)

Kashiwagi, M., Tortorella, M. D., Nagase, H., & Brew, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000848200 · Cited by 509 · see citing works

Complex roles of tissue inhibitors of metalloproteinases in cancer

Jiang, Y., Goldberg, I. D., & Shi, Y. E. (2002) · Oncogene · doi:10.1038/sj.onc.1205291 · Cited by 508 · see citing works

Molecular Determinants of Metalloproteinase Substrate Specificity: Matrix Metalloproteinase Substrate Binding Domains, Modules, and Exosites

Overall, C. M. (2002) · Molecular Biotechnology · doi:10.1385/mb:22:1:051 · Cited by 506 · see citing works

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15234 · Cited by 485 · see citing works

Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor

Rodrı́guez-Manzaneque, J. C., Lane, T. F., Ortega, M.-A., Hynes, R. O., Lawler, J., & Iruela‐Arispe, M. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171460498 · Cited by 473 · see citing works

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

Khokha, R., Waterhouse, P. D., Yagel, S., Lala, P. K., Overall, C. M., Norton, G., & Denhardt, D. T. (1989) · Science · doi:10.1126/science.2465572 · Cited by 451 · see citing works

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

Kerr, L. D., Miller, D. B., & Matrisian, L. M. (1990) · Cell · doi:10.1016/0092-8674(90)90807-q · Cited by 443 · see citing works

Matrix Metalloproteinases Generate Angiostatin: Effects on Neovascularization

Cornelius, L. A., Nehring, L. C., Harding, E., Bolanowski, M. A., Welgus, H. G., Kobayashi, D. K., Pierce, R. A., & Shapiro, S. D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.12.6845 · Cited by 443 · see citing works

Marimastat as First-Line Therapy for Patients With Unresectable Pancreatic Cancer: A Randomized Trial

Bramhall, S. R., Rosemurgy, A. S., Brown, P. D. N., Bowry, C., BUCKELS, J. A. C., & for the Marimastat Pancreatic Cancer Study Group (2001) · Journal of Clinical Oncology · doi:10.1200/jco.2001.19.15.3447 · Cited by 437 · see citing works

METH-1, a Human Ortholog of ADAMTS-1, and METH-2 Are Members of a New Family of Proteins with Angio-inhibitory Activity

Vázquez, F., Hastings, G. A., Ortega, M.-A., Lane, T. F., Oikemus, S., Lombardo, M., & Iruela‐Arispe, M. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23349 · Cited by 426 · see citing works

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

Muraoka, R. S., Dumont, N., Ritter, C. A., Dugger, T. C., Brantley, D. M., Chen, J., Easterly, E., Roebuck, L. R., Ryan, S. T., Gotwals, P. J., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215234 · Cited by 415 · see citing works

TNF-α stimulates activation of pro-MMP2 in human skin through NF-κB mediated induction of MT1-MMP

Han, Y.-P., Tuan, T., Wu, H., Hughes, M. W., & Garner, W. L. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.1.131 · Cited by 412 · see citing works

The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3

Amour, A., Knight, C. G., Webster, A., Slocombe, P. M., Stephens, P. E., Knäuper, V., Docherty, A., & Murphy, G. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01528-3 · Cited by 404 · see citing works

Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change

Kheradmand, F., Werner, E., Tremble, P., Symons, M. H., & Werb, Z. (1998) · Science · doi:10.1126/science.280.5365.898 · Cited by 391 · see citing works

MT1-MMP Initiates Activation of pro-MMP-2 and Integrin αvβ3 Promotes Maturation of MMP-2 in Breast Carcinoma Cells

Deryugina, E. I., Ratnikov, B. I., Monosov, E., et al. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5118 · Cited by 388 · see citing works

Structural properties of matrix metalloproteinases

Bode, W., Fernandez-Catalan, C., Tschesche, F. G. H., & H. Nagase, K. M. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050320 · Cited by 328 · see citing works

New Functions for Non-collagenous Domains of Human Collagen Type IV

Petitclerc, É., Boutaud, A., Prestayko, A. W., Xu, J., Sado, Y., Ninomiya, Y., Sarras, M. P., Hudson, B. G., & Brooks, P. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.8051 · Cited by 316 · see citing works

Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase.

Kim, Y. M., Jang, J.-W., Lee, O., Yeon, J.-H., Choi, E.-Y., Kim, K., Lee, S., & Kwon, Y. (2000) · PubMed · Cited by 315 · see citing works

HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma

Sgadari, C., Barillari, G., Toschi, E., Carlei, D., Bacigalupo, I., Baccarini, S., Palladino, C., Leone, P., Bugarini, R., Malavasi, L., et al. (2002) · Nature Medicine · doi:10.1038/nm0302-225 · Cited by 308 · see citing works

Membrane‐type matrix metalloproteinases

Seiki, M. (1999) · Apmis · doi:10.1111/j.1699-0463.1999.tb01536.x · Cited by 300 · see citing works

Extracellular Matrix Metalloproteinase 2 Levels Are Regulated by the Low Density Lipoprotein-related Scavenger Receptor and Thrombospondin 2

Yang, Z., Strickland, D. K., & BORNSTEIN, P. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008925200 · Cited by 297 · see citing works

Stromelysin‐1: Three‐dimensional structure of the inhibited catalytic domain and of the C‐truncated proenzyme

Becker, J. W., Marcy, A. I., Rokosz, L. L., Axel, M. G., Burbaum, J. J., Fitzgerald, P. M. D., Cameron, P. M., Esser, C. K., Hagmann, W. K., Hermes, J. D., et al. (1995) · Protein Science · doi:10.1002/pro.5560041002 · Cited by 293 · see citing works

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

Baker, A. H., George, S. J., Zaltsman, A. B., Murphy, G., & Newby, A. C. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690217 · Cited by 286 · see citing works

Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Binds to the Catalytic Domain of the Cell Surface Receptor, Membrane Type 1-Matrix Metalloproteinase 1 (MT1-MMP)

Zucker, S., Drews, M., Conner, C. E., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.2.1216 · Cited by 281 · see citing works

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

André, P., Groettrup, M., Klenerman, P., de Giuli, R., Booth, B. L., Cerundolo, V., Bonneville, M., Jotereau, F., Zinkernagel, R. M., & Lotteau, V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13120 · Cited by 279 · see citing works

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.

Lal, A., Glazer, C. A., Martinson, H. M., Friedman, H. S., Archer, G. E., Sampson, J. H., & Riggins, G. J. (2002) · PubMed · Cited by 278 · see citing works

Curcuminoids Inhibit the Angiogenic Response Stimulated by Fibroblast Growth Factor-2, Including Expression of Matrix Metalloproteinase Gelatinase B

Mohan, R., Sivak, J. M., Ashton, P., Russo, L. A., Pham, B. Q., Kasahara, N., Raizman, M. B., & Fini, M. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10405 · Cited by 274 · see citing works

Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains

Cal, S., Obaya, Á. J., Prada, M. L., Garabaya, C., Quesada, V., & López-Otı́n, C. (2002) · Gene · doi:10.1016/s0378-1119(01)00861-7 · Cited by 273 · see citing works

Functional overlap between two classes of matrix‐degrading proteases in wound healing

Lund, L. R., Rømer, J., Bugge, T. H., Nielsen, B. S., Frandsen, T. L., Degen, J. L., Stephens, R. W., & Danø, K. (1999) · The EMBO Journal · doi:10.1093/emboj/18.17.4645 · Cited by 270 · see citing works

Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial

Bramhall, S. R., Hallissey, M. T., Whiting, J., et al. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600310 · Cited by 268 · see citing works

Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo

Silletti, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.011343298 · Cited by 262 · see citing works

HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: A potential mechanism for protease inhibitor-induced hyperlipidemia

Liang, J.-S., Distler, O., Cooper, D. A., Jamil, H., Deckelbaum, R. J., Ginsberg, H. N., & Sturley, S. L. (2001) · Nature Medicine · doi:10.1038/nm1201-1327 · Cited by 260 · see citing works

Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2

Bein, K., & Simons, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003834200 · Cited by 257 · see citing works

Membrane Type 1-Matrix Metalloproteinase Is Activated during Migration of Human Endothelial Cells and Modulates Endothelial Motility and Matrix Remodeling

Gálvez, B. G., Matı́as-Román, S., Albar, J. P., Sánchez‐Madrid, F., & Arroyo, A. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104094200 · Cited by 251 · see citing works

Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase

Johansson, N., Ala‐aho, R., Uitto, V., Grenman, R. A., Fusenig, N. E., López-Otı́n, C., & Kähäri, V. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.2.227 · Cited by 243 · see citing works

Identification and Enzymatic Characterization of Two Diverging Murine Counterparts of Human Interstitial Collagenase (MMP-1) Expressed at Sites of Embryo Implantation

Balbı́n, M., Fueyo, A., Knäuper, V., López, J. M., Álvarez, J., Sánchez, L. M., Quesada, V., Bordallo, J., Murphy, G., & López-Otı́n, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007674200 · Cited by 239 · see citing works

Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.

Simon, C., Goepfert, H., & Boyd, D. (1998) · PubMed · Cited by 238 · see citing works

Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis

Herman, M. P., Sukhova, G. K., Kisiel, W., Foster, D., Kehry, M. R., Libby, P., & Schönbeck, U. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10403 · Cited by 236 · see citing works

Cloning and Characterization of Human MMP-23, a New Matrix Metalloproteinase Predominantly Expressed in Reproductive Tissues and Lacking Conserved Domains in Other Family Members

Velasco, G., Pendás, A. M., Fueyo, A., Knäuper, V., Murphy, G., & López-Otı́n, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4570 · Cited by 232 · see citing works

Phase II Trial of Temozolomide Plus the Matrix Metalloproteinase Inhibitor, Marimastat, in Recurrent and Progressive Glioblastoma Multiforme

Groves, M. D., Puduvalli, V. K., Hess, K. R., Jaeckle, K. A., Peterson, P., Yung, W. K. A., & Levin, V. A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.5.1383 · Cited by 229 · see citing works

Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2

Morgunova, E. Y., Tuuttila, A., Bergmann, U., & Tryggvason, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102185399 · Cited by 222 · see citing works

Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system.

Hua, J., & Muschel, R. J. (1996) · PubMed · Cited by 214 · see citing works

Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity.

Urı́a, J. A., & López-Otı́n, C. (2000) · PubMed · Cited by 208 · see citing works

Proprotein Convertases in Tumor Progression and Malignancy

Khatib, A., Siegfried, G., Chrétien, M., Metrakos, P. P., & Seidah, N. G. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61140-6 · Cited by 202 · see citing works

Structural Analysis and Promoter Characterization of the Human Collagenase-3 Gene (MMP13)

Pendás, A. M., Balbı́n, M., Llano, E., Jiménez, M., & López-Otı́n, C. (1997) · Genomics · doi:10.1006/geno.1996.4554 · Cited by 200 · see citing works

Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.

Velasco, G., Cal, S., Merlos‐Suárez, A., et al. (2000) · PubMed · Cited by 197 · see citing works

Differential Effects of Transforming Growth Factor-β on the Expression of Collagenase-1 and Collagenase-3 in Human Fibroblasts

Urı́a, J. A., Jiménez, M., Balbı́n, M., Freije, J. M. P., & López-Otı́n, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9769 · Cited by 193 · see citing works

Cellular Activation of MMP-2 (Gelatinase A) by MT2-MMP Occurs via a TIMP-2-independent Pathway

Morrison, C., Butler, G. S., Bigg, H. F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108643200 · Cited by 181 · see citing works

Regulation of Matrix Metalloproteinase Gene Expression

Fini, M. E., Cook, J. R., Mohan, R., & Brinckerhoff, C. (1998) · Elsevier eBooks · doi:10.1016/b978-012545090-4/50013-6 · Cited by 177 · see citing works

The PEA3 Subfamily of Ets Transcription Factors Synergizes with β-Catenin–LEF-1 To Activate Matrilysin Transcription in Intestinal Tumors

Crawford, H. C., Fingleton, B., Gustavson, M. D., Kurpios, N. A., Wagenaar-Miller, R. A., Hassell, J. A., & Matrisian, L. M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.4.1370-1383.2001 · Cited by 175 · see citing works

cDNA Cloning of the MurinePexGene Implicated in X-Linked Hypophosphatemia and Evidence for Expression in Bone

Du, L., Desbarats, M., Viel, J., et al. (1996) · Genomics · doi:10.1006/geno.1996.0421 · Cited by 175 · see citing works

Activity loss and the onset of depressive symptoms: Do some activities matter more than others?

Katz, P., & Yelin, E. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200105)44:5 · Cited by 175 · see citing works

Nuclear Factor κB Activity Is Essential for Matrix Metalloproteinase-1 and -3 Upregulation in Rabbit Dermal Fibroblasts

Bond, M., Baker, A. H., & Newby, A. C. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1551 · Cited by 173 · see citing works

Halofuginone, an Inhibitor of Type-I Collagen Synthesis and Skin Sclerosis, Blocks Transforming-Growth-Factor-β-Mediated Smad3 Activation in Fibroblasts

McGaha, T. L., Bona, C. A., Phelps, R. G., & Spiera, H. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01690.x · Cited by 170 · see citing works

AP-1--glucocorticoid receptor crosstalk taken to a higher level

Karin, M., & Chang, L. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690447 · Cited by 167 · see citing works

Green tea polyphenol (−)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells

Annabi, B., Lachambre, M., Bousquet-Gagnon, N., Pagé, M., Gingras, D., & Béliveau, R. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(01)00187-2 · Cited by 165 · see citing works

Selective suppression of matrix metalloproteinase-9 in human glioblastoma cells by antisense gene transfer impairs glioblastoma cell invasion.

Kondraganti, S. R., Mohanam, S., Chintala, S. K., et al. (2000) · PubMed · Cited by 163 · see citing works

Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells

Bassi, D., de Cicco, R. L., Mahloogi, H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191199198 · Cited by 159 · see citing works

Matrilysin [MMP-7] Expression Selects for Cells with Reduced Sensitivity to Apoptosis

Fingleton, B., Vargo-Gogola, T. C., Crawford, H. C., & Matrisian, L. M. (2001) · Neoplasia · doi:10.1038/sj.neo.7900190 · Cited by 158 · see citing works

Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.

Sato, T., Koike, L., Miyata, Y., et al. (2002) · PubMed · Cited by 155 · see citing works

Substrate Binding of Gelatinase B Induces Its Enzymatic Activity in the Presence of Intact Propeptide

Bannikov, G. A., Karelina, T. V., Collier, I. E., Marmer, B. L., & Goldberg, G. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110931200 · Cited by 154 · see citing works

Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis

Pozzi, A., LeVine, W. F., & Gardner, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205045 · Cited by 154 · see citing works

Transcriptional Suppression of Matrix Metalloproteinase-9 Gene Expression by IFN-γ and IFN-β: Critical Role of STAT-1α

Ma, Z., Qin, H., & Benveniste, E. N. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5150 · Cited by 152 · see citing works

Matrix Metalloproteinase Inhibitor COL-3 in the Treatment of AIDS-Related Kaposi's Sarcoma: A Phase I AIDS Malignancy Consortium Study

Cianfrocca, M. E. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.1.153 · Cited by 149 · see citing works

The promise and peril of surrogate end points in cancer research

Schatzkin, A. G., & Gail, M. H. (2002) · Nature reviews. Cancer · doi:10.1038/nrc702 · Cited by 148 · see citing works

Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes.

Nakada, M., Yamada, A. Y., Takino, T., et al. (2001) · PubMed · Cited by 146 · see citing works

Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase.

Bigg, H. F., Morrison, C., Butler, G. S., et al. (2001) · PubMed · Cited by 144 · see citing works

p53 Down-regulates Human Matrix Metalloproteinase-1 (Collagenase-1) Gene Expression

Sun, Y., Sun, Y., Wenger, L., Rutter, J. L., Brinckerhoff, C., & Cheung, H. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11535 · Cited by 143 · see citing works

Cysteine Array Matrix Metalloproteinase (CA-MMP)/MMP-23 Is a Type II Transmembrane Matrix Metalloproteinase Regulated by a Single Cleavage for Both Secretion and Activation

Pei, D., Kang, T., & Qi, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006493200 · Cited by 142 · see citing works

Collagen Binding Properties of the Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Hemopexin C Domain

Tam, E. M., Wu, Y., Butler, G. S., Stack, M. S., & Overall, C. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206874200 · Cited by 141 · see citing works

Suppression of angiogenesis by lentiviral delivery of PEX, a noncatalytic fragment of matrix metalloproteinase 2

Pfeifer, A., Keßler, T., Silletti, S., Cheresh, D. A., & Verma, I. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220399597 · Cited by 137 · see citing works

An inhibitor of c-jun aminoterminal kinase (SP600125) represses c-Jun activation, DNA-binding and PMA-inducible 92-kDa type IV collagenase expression

Shin, M., Yan, C., & Boyd, D. D. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00195-7 · Cited by 137 · see citing works

Phase I and pharmacological study of the oral matrix metalloproteinase inhibitor, MMI270 (CGS27023A), in patients with advanced solid cancer.

Levitt, N. C., Eskens, F. A. L. M., O'Byrne, K. J., et al. (2001) · PubMed · Cited by 137 · see citing works

Tissue Inhibitor of Metalloproteinase (TIMP)-2 Acts Synergistically with Synthetic Matrix Metalloproteinase (MMP) Inhibitors but Not with TIMP-4 to Enhance the (Membrane Type 1)-MMP-dependent Activation of Pro-MMP-2

Tóth, M., Bernardo, M. M., Gervasi, D. C., Soloway, P. D., Wang, Z., Bigg, H. F., Overall, C. M., DeClerck, Y. A., Tschesche, H., Cher, M. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006871200 · Cited by 134 · see citing works

CIZ, a Zinc Finger Protein That Interacts with p130 cas and Activates the Expression of Matrix Metalloproteinases

Nakamoto, T., Yamagata, T., Sakai, R., Ogawa, S., Honda, H., Ueno, H., Hirano, N., Yazaki, Y., & Hirai, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1649-1658.2000 · Cited by 133 · see citing works

Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.

Liu, S., Netzel–Arnett, S., Birkedal‐Hansen, H., et al. (2000) · PubMed · Cited by 132 · see citing works

Post-translational Proteolytic Processing of Procollagen C-terminal Proteinase Enhancer Releases a Metalloproteinase Inhibitor

Mott, J. D., Thomas‐Virnig, C. L., Rosenbach, M. T., Takahara, K., Greenspan, D. S., & Banda, M. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1384 · Cited by 131 · see citing works

Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.

Krüger, A., Soeltl, R., Sopov, I., et al. (2001) · PubMed · Cited by 127 · see citing works

Clinical studies with matrix metalloproteinase inhibitors

Brown, P. D. N. (1999) · Apmis · doi:10.1111/j.1699-0463.1999.tb01541.x · Cited by 125 · see citing works

Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer.

Duivenvoorden, W., Popović, S., Lhoták, Š., Seidlitz, E. P., Hirte, H. W., Tozer, R. G., & Singh, G. (2002) · PubMed · Cited by 124 · see citing works

Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials

Falardeau, P., Champagne, P., Poyet, P., Hariton, C., & Dupont, �. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90035-1 · Cited by 122 · see citing works

Phase II Trial of Temozolomide Plus the Matrix Metalloproteinase Inhibitor, Marimastat, in Recurrent and Progressive Glioblastoma Multiforme

Groves, M. D., Puduvalli, V. K., Hess, K. R., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.5.1383 · Cited by 118 · see citing works

Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2.

Bello, L., Lucini, V., Carrabba, G. G., Giussani, C. G., Machluf, M., Pluderi, M., Nikas, D. L., Zhang, J., Tomei, G., Villani, R. M., et al. (2001) · PubMed · Cited by 113 · see citing works

Punctin, a Novel ADAMTS-like Molecule, ADAMTSL-1, in Extracellular Matrix

Hirohata, S., Wang, L. W., Miyagi, M., Yan, L., Seldin, M. F., Keene, D. R., Crabb, J. W., & Apte, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109665200 · Cited by 110 · see citing works

Inhibition of angiogenesis and metastasis in two murine models by the matrix metalloproteinase inhibitor, BMS-275291.

Naglich, J. G., Jure‐Kunkel, M., Gupta, E., Fargnoli, J., Henderson, A. J., Lewin, A. C., Talbott, R. L., Baxter, A., Bird, J., Savopoulos, R., et al. (2001) · PubMed · Cited by 110 · see citing works

TEL, a Putative Tumor Suppressor, Modulates Cell Growth and Cell Morphology of Ras-Transformed Cells While Repressing the Transcription of stromelysin-1

Fenrick, R., Wang, L., Nip, J., Amann, J. M., Rooney, R. J., Walker‐Daniels, J., Crawford, H. C., Hulboy, D. L., Kinch, M. S., Matrisian, L. M., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5828-5839.2000 · Cited by 106 · see citing works

A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation

Jiménez, M. J. G., Balbı́n, M., Álvarez, J., Komori, T., Bianco, P., Holmbeck, K., Birkedal‐Hansen, H., López, J. M., & López-Otı́n, C. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200106147 · Cited by 102 · see citing works

Domain Interactions in the Gelatinase A·TIMP-2·MT1-MMP Activation Complex

Overall, C. M., Tam, E. M., McQuibban, G. A., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005932200 · Cited by 98 · see citing works

Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor

Maquoi, E., Noël, A., Frankenne, F., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00187-2 · Cited by 97 · see citing works

MMP1 and MMP3 Polymorphisms in Promoter Regions and Cancer

Biondi, M. L., Turri, O., Leviti, S., et al. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.12.2023 · Cited by 96 · see citing works

Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 (hMMP-13)

Sun, Y., Cheung, J. M., Martel‐Pelletier, J., Pelletier, J. P., Wenger, L., Altman, R. D., Howell, D. S., & Cheung, H. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11327 · Cited by 95 · see citing works

The Involvement of the Fibronectin Type II-like Modules of Human Gelatinase A in Cell Surface Localization and Activation

Steffensen, B., Bigg, H. F., & Overall, C. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20622 · Cited by 90 · see citing works

Altered Tumor Growth and Metastasis of a T-Cell Lymphoma in Timp-1 Transgenic Mice

Krüger, A., Fata, J. E., & Khokha, R. (1997) · Blood · doi:10.1182/blood.v90.5.1993 · Cited by 86 · see citing works

Identification of the Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Binding Site on the Hemopexin Carboxyl Domain of Human Gelatinase A by Site-directed Mutagenesis

Overall, C. M., King, A. E., Sam, D. K., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.4421 · Cited by 84 · see citing works

Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases

Bernardo, M. M., Brown, S., Li, Z., Fridman, R. A., & Mobashery, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111021200 · Cited by 81 · see citing works

Matrilysin in early stage intestinal tumorigenesis

Fingleton, B., Goss, K. H., Crawford, H. C., & Matrisian, L. M. (1999) · Apmis · doi:10.1111/j.1699-0463.1999.tb01532.x · Cited by 80 · see citing works

Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90.

Zhang, Y., Thant, A. A., Machida, K., Ichigotani, Y., Naito, Y., Hiraiwa, Y., Senga, T., Sohara, Y., Matsuda, S., & Hamaguchi, M. (2002) · PubMed · Cited by 76 · see citing works

Isolation and Characterization of Two Novel Metalloproteinase Genes Linked to theCdc2LLocus on Human Chromosome 1p36.3

Gururajan, R., Grenet, J. A., Lahti, J. M., & Kidd, V. J. (1998) · Genomics · doi:10.1006/geno.1998.5401 · Cited by 75 · see citing works

Adenoviral delivery of p53 gene suppresses expression of collagenase-3 (MMP-13) in squamous carcinoma cells

Ala‐aho, R., Grenman, R. A., Seth, P. K., & Kähäri, V. (2002) · Oncogene · doi:10.1038/sj.onc.1205198 · Cited by 70 · see citing works

Transgenic TIMP-1 inhibits simian virus 40 T antigen-induced hepatocarcinogenesis by impairment of hepatocellular proliferation and tumor angiogenesis.

Martin, D. C., Sanchez-Sweatman, O. H., Ho, A. T. V., et al. (1999) · PubMed · Cited by 69 · see citing works

Non‐steroidal anti‐inflammatory drugs inhibit matrix metalloproteinase‐2 expression via repression of transcription in lung cancer cells

Pan, M., Chuang, L., & Hung, W. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03118-0 · Cited by 68 · see citing works

Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding

Blobel, C. (2002) · Inflammation Research · doi:10.1007/bf02684007 · Cited by 66 · see citing works

Selective transduction of protease-rich tumors by matrix-metalloproteinase-targeted retroviral vectors

Peng, K.-W., Vile, R. G., Cosset, F., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300982 · Cited by 66 · see citing works

Treatment with low-dose interferon-alpha restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder.

Slaton, J. W., Karashima, T., Perrotte, P., et al. (2001) · PubMed · Cited by 64 · see citing works

Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1

Ala‐aho, R., Johansson, N., Grenman, R. A., et al. (2000) · Oncogene · doi:10.1038/sj.onc.1203306 · Cited by 59 · see citing works

The laminin-binding domain of agrin is structurally related to N-TIMP-1.

Stetefeld, J., Jenny, M., Schulthess, T., et al. (2001) · Nature Structural Biology · doi:10.1038/90422 · Cited by 47 · see citing works

Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs

van Lent, P. L. E. M., Holthuysen, A. E. M., Sloetjes, A. W., et al. (2002) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0501 · Cited by 46 · see citing works

Stimulation of Matrix Metalloproteinase-9 Expression in Human Fibrosarcoma Cells by Synthetic Matrix Metalloproteinase Inhibitors

Maquoi, E., Munaut, C., Colige, A., Lambert, C. A., Frankenne, F., Noël, A., Grams, F., Krell, H., & Foidart, J. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5489 · Cited by 32 · see citing works

Protease inhibitors in oral carcinogenesis and chemoprevention.

Lippman, S. M., & Matrisian, L. M. (2000) · PubMed · Cited by 28 · see citing works

Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients

Rozen, P., Lubin, F., Papo, N., Knaani, J., Farbstein, H., Farbstein, M., & Zajicek, G. (2001) · Cancer · doi:10.1002/1097-0142(20010215)91:4 · Cited by 27 · see citing works

Membrane Type 1 Matrix Metalloproteinase Regulates Cellular Invasiveness and Survival in Cutaneous Epidermal Cells

Nagavarapu, U., Relloma, K., & Herron, G. S. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01713.x · Cited by 22 · see citing works

A Novel Negative Regulatory Element in the Human Collagenase-3 Proximal Promoter Region

Benderdour, M., Tardif, G., Pelletier, J., et al. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6580 · Cited by 20 · see citing works

Repression of tissue inhibitor of matrix metalloproteinase expression by all‐trans‐retinoic acid in rat bone cell populations: Comparison with transforming growth factor‐βT1

Overall, C. M. (1995) · Journal of Cellular Physiology · doi:10.1002/jcp.1041640104 · Cited by 20 · see citing works

Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-mediated transformation activity with suppression of MMP-1 and MMP-9 in NIH3T3 cells

Futamura, M., Kamiya, S., Tsukamoto, M., Hirano, A., Monden, Y., Arakawa, H., & Nishimura, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204878 · Cited by 16 · see citing works

Interleukin-2-collagen chimeric protein which liberates interleukin-2 upon collagenolysis

Hayashi, M., Tomita, M., & Yoshizato, K. (2002) · Protein Engineering Design and Selection · doi:10.1093/protein/15.5.429 · Cited by 10 · see citing works

Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5 · see citing works

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works

Matrix metalloproteinases as modulators of inflammation and innate immunity

Parks, W. C., Wilson, C. L., & López-Boado, Y. S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1418 · Cited by 1,929 · see citing works

Extracellular matrix and its therapeutic potential for cancer treatment

Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962 · see citing works

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Rosenberg, G. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70016-x · Cited by 594 · see citing works

The regulation of matrix metalloproteinases and their inhibitors

Clark, I. M., Swingler, T. E., Sampieri, C. L., & Edwards, D. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.12.006 · Cited by 555 · see citing works

The role of matrix metalloproteinases (MMPs) in human caries

Chaussain-Miller, C., Fioretti, F., Goldberg, M., & Menashi, S. (2006) · Journal of Dental Research · doi:10.1177/154405910608500104 · Cited by 481 · see citing works

Adipocyte-derived endotrophin promotes malignant tumor progression

Park, J., & Scherer, P. E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63930 · Cited by 350 · see citing works

Barriers to drug delivery in solid tumors

Sriraman, S. K., Aryasomayajula, B., & Torchilin, V. P. (2014) · Tissue Barriers · doi:10.4161/tisb.29528 · Cited by 338 · see citing works

Matrix metalloproteases in aberrant fibrotic tissue remodeling

Pardo, A., & Selman, M. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200601-012tk · Cited by 260 · see citing works

EWS–ETS oncoproteins: The linchpins of Ewing tumors

Janknecht, R. (2005) · Gene · doi:10.1016/j.gene.2005.08.007 · Cited by 173 · see citing works

Two Different Zinc Transport Complexes of Cation Diffusion Facilitator Proteins Localized in the Secretory Pathway Operate to Activate Alkaline Phosphatases in Vertebrate Cells

Suzuki, T., Ishihara, K., Migaki, H., Ishihara, K., Nagao, M., Yamaguchi-Iwai, Y., & Kambe, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506902200 · Cited by 168 · see citing works

EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9

Luo, K.-W., Chen, W., Lung, W.-Y., Wei, X.-Y., Cheng, B.-H., Cai, Z.-M., & Huang, W.-R. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.12.004 · Cited by 137 · see citing works

TNF-α promotes breast cancer cell migration and enhances the concentration of membrane-associated proteases in lipid rafts

Wolczyk, D., Zaremba-Czogalla, M., Hryniewicz-Jankowska, A., Tabola, R., Grabowski, K., Sikorski, A. F., & Augoff, K. (2016) · Cellular Oncology · doi:10.1007/s13402-016-0280-x · Cited by 116 · see citing works

Zinc Transport Complexes Contribute to the Homeostatic Maintenance of Secretory Pathway Function in Vertebrate Cells

Ishihara, K., Yamazaki, T., Ishida, Y., Suzuki, T., Oda, K., Nagao, M., Yamaguchi-Iwai, Y., & Kambe, T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602470200 · Cited by 104 · see citing works

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

Gutiérrez‐Fernández, A., Soria‐Valles, C., Osorio, F. G., Gutiérrez‐Abril, J., Garabaya, C., Aguirre, A., Fueyo, A., Fernández‐García, M. S., Puente, X. S., & López‐Otín, C. (2015) · The EMBO Journal · doi:10.15252/embj.201490594 · Cited by 96 · see citing works

New approaches to selectively target cancer-associated matrix metalloproteinase activity

Tauro, M., McGuire, J., & Lynch, C. C. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9530-4 · Cited by 70 · see citing works

Fucoidan increases TNF-α-induced MMP-9 secretion in monocytic cell line U937

Jintang, S., Alei, F., Yun, Z., Shanzhen, S., Weixu, H., Meixiang, Y., Fengcai, W., & Xun, Q. (2010) · Inflammation Research · doi:10.1007/s00011-009-0095-6 · Cited by 27 · see citing works

Progress in study of matrix metalloproteinases and tumour invasion and metastasis

Chen, X. (2001) · Zhongguo yaolixue tongbao

Effects of matrix metalloproteinase on the invasion and metastasis of antitumor

Yin, L. (2009) · Journal of Chongqing Technology and Business University

MATRIX METALLOPROTEINASES AND METASTASIS OF LUNG CANCER

Mian, W. (2003) · Xiandai yufang yixue · Cited by 1 · see citing works

Matrix metalloproteinases-2， -9 and tissue inhibitor of metalloproteinase-1 in lung cancer invasion and metastasis

MINGShu-hong, SUNTie-ying, Xiaowei, X., et al. (2005) · 中华医学杂志：英文版 · Cited by 2 · see citing works

Research advance of matrix metalloproteinases with p53 and nuclear factor-kappaB in tumor invasion and metastasis

Yan, J., & Zhu, Y. K. (2009) · Chinese Journal of Asthma · doi:10.3760/cma.j.issn.1673-436x.2009.018.004