Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice
Open accessAbstract
Excess carbohydrate intake causes obesity in humans. On the other hand, acute administration of fructose, glucose or sucrose in experimental animals has been shown to increase the plasma concentration of anti-obesity hormones such as glucagon-like peptide 1 (GLP-1) and Fibroblast growth factor 21 (FGF21), which contribute to reducing body weight. However, the secretion and action of GLP-1 and FGF21 in mice chronically fed a high-sucrose diet has not been investigated. To address the role of anti-obesity hormones in response to increased sucrose intake, we analyzed mice fed a high-sucrose diet, a high-starch diet or a normal diet for 15 weeks. Mice fed a high-sucrose diet showed resistance to body weight gain, in comparison with mice fed a high-starch diet or control diet, due to increased energy expenditure. Plasma FGF21 levels were highest among the three groups in mice fed a high-sucrose diet, whereas no significant difference in GLP-1 levels was observed. Expression levels of uncoupling protein 1 (UCP-1), FGF receptor 1c (FGFR1c) and β-klotho (KLB) mRNA in brown adipose tissue were significantly increased in high sucrose-fed mice, suggesting increases in FGF21 sensitivity and energy expenditure. Expression of carbohydrate responsive element binding protein (ChREBP) mRNA in liver and brown adipose tissue was also increased in high sucrose-fed mice. These results indicate that FGF21 production in liver and brown adipose tissue is increased in high-sucrose diet and participates in resistance to weight gain.
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Circulating FGF21 levels are robustly increased by diets that are high in carbohydrate but low in protein.
“Circulating FGF21 levels are robustly increased by diets that are high in carbohydrate but low in protein”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [139]
Liver FGF21 production is robustly stimulated by an imbalance in macronutrients, particularly settings of high-carbohydrate but low-protein intake.
“liver FGF21 production seems to be robustly stimulated by an imbalance in macronutrients, particularly settings of high-carbohydrate but low-protein intake”
From FGF21 and the physiological regulation of macronutrient preference (2020) · cites this paper as [139]
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- Authors
- Maekawa, R., Seino, Y., Ogata, H., Murase, M., Iida, A., Hosokawa, K., Joo, E., Harada, N., Tsunekawa, S., Hamada, Y., Oiso, Y., Inagaki, N., Hayashi, Y., & Arima, H.
- Affiliations
- Nagoya University (JP)
- Kyoto University (JP)
- Research Institute of Environmental Medicine, Nagoya University (JP)
- Corresponding author
- Seino, Yusuke
- Hayashi, Yoshitaka
- ORCID
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 49
- Pages
- 71-79
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2737066966
- Cited by
- 56
- References
- 41
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 2 · 2019: 8 · 2018: 4
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (25461338, 15H04681, 15K15356, 17K09823)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- high-sucrose diet, FGF21, energy expenditure, glucagon-like peptide-1, brown adipose tissue, UCP1, β-Klotho, carbohydrate-responsive element-binding protein, obesity, fructose
- MeSH terms
- Diet, Carbohydrate Loading, Uncoupling Protein 1, Klotho Proteins, Animals, Adipose Tissue, Brown, Energy Metabolism, Fibroblast Growth Factors, Insulin Resistance, Liver, Male, Membrane Proteins, Mice, Inbred C57BL, Nuclear Proteins, Organ Specificity, Starch, Transcription Factors, Reproducibility of Results, Weight Gain, Gene Expression Regulation, Developmental, Dietary Sucrose, Receptor, Fibroblast Growth Factor, Type 1, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Adipose Tissue, White
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