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Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue

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From Food to Genes: Transcriptional Regulation of Metabolism by Lipids and Carbohydrates

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Type VIII Collagen Modulates TGF-β1-induced Proliferation of Mesangial Cells

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The regulation of FGF21 gene expression by metabolic factors and nutrients

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Multi-organ FGF21-FGFR1 signaling in metabolic health and disease

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Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK

Vernia, S., Cavanagh, J., Barrett, T., Tournier, C., & Davis, R. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.026 · Cited by 48 · see citing works

Fibroblast growth factor 21 coordinates adiponectin to mediate the beneficial effects of low-protein diet on primordial follicle reserve

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Organokines in disease

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ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits

Singh, C., Jin, B., Shrestha, N., Markhard, A. L., Panda, A., Calvo, S. E., Deik, A., Pan, X., Zuckerman, A. L., Saad, A. B., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.11.010 · Cited by 46 · see citing works

ChREBP-Knockout Mice Show Sucrose Intolerance and Fructose Malabsorption

Kato, T., Iizuka, K., Takao, K., Horikawa, Y., Kitamura, T., & Takeda, J. (2018) · Nutrients · doi:10.3390/nu10030340 · Cited by 46 · see citing works

Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review)

Zhou, L. Q., Ran, L., He, Y., & Huang, Y. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13463 · Cited by 48 · see citing works

Fibroblast growth factor 21: an endocrine inhibitor of sugar and alcohol appetite

von Holstein‐Rathlou, S., & Gillum, M. P. (2019) · The Journal of Physiology · doi:10.1113/jp277117 · Cited by 44 · see citing works

Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice

Zhao, C., Liu, L., Liu, Q., Li, F., Zhang, L., Zhu, F., Shao, T., Barve, S. S., Chen, Y., Li, X., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.020 · Cited by 46 · see citing works

Krüppel-like factor-10 is directly regulated by carbohydrate response element-binding protein in rat primary hepatocytes

Iizuka, K., Takeda, J., & Horikawa, Y. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.016 · Cited by 44 · see citing works

ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in β–Cell Line

Sae‐Lee, C., Moolsuwan, K., Chan, L., & Poungvarin, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147411 · Cited by 43 · see citing works

Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice

Chaumontet, C., Azzout-Marniche, D., Blais, A., Piedcoq, J., Tomé, D., Gaudichon, C., & Even, P. C. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00316.2018 · Cited by 42 · see citing works

Multiple effects of cold exposure on livers of male mice

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Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency

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ChREBP Reciprocally Regulates Liver and Plasma Triacylglycerol Levels in Different Manners

Iizuka, K., Takao, K., Kato, T., Horikawa, Y., & Takeda, J. (2018) · Nutrients · doi:10.3390/nu10111699 · Cited by 41 · see citing works

The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions

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Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression

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Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis

McKeown, N. M., Dashti, H. S., Ma, J., Haslam, D. E., Jong, J. C. K., Smith, C. E., Tanaka, T., Graff, M., Lemaître, R. N., Rybin, D. V., et al. (2017) · Diabetologia · doi:10.1007/s00125-017-4475-0 · Cited by 40 · see citing works

Sugar sensing by ChREBP/Mondo-Mlx — new insight into downstream regulatory networks and integration of nutrient-derived signals

Havula, E., & Hietakangas, V. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.12.007 · Cited by 38 · see citing works

Feedback looping between ChREBP and PPARα in the regulation of lipid metabolism in brown adipose tissues

Iizuka, K., Wu, W., Horikawa, Y., Saito, M., & Takeda, J. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0079 · Cited by 38 · see citing works

Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes

Chalvon-Demersay, T., Even, P. C., Tomé, D., Chaumontet, C., Piedcoq, J., Gaudichon, C., & Azzout-Marniche, D. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.07.002 · Cited by 37 · see citing works

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

Wu, W., Tsuchida, H., Kato, T., Niwa, H., Horikawa, Y., Takeda, J., & Iizuka, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.04.092 · Cited by 37 · see citing works

Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state

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Emerging Structure–Function Paradigm of Endocrine FGFs in Metabolic Diseases

Luo, Y., Ye, S., Li, X., & Lu, W. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.12.002 · Cited by 36 · see citing works

Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents

Bisgaard, A., Sørensen, K., Johannsen, T. H., Helge, J. W., Andersson, A., & Juul, A. (2014) · International Journal of Pediatric Endocrinology · doi:10.1186/1687-9856-2014-7 · Cited by 34 · see citing works

Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis

Khan, M. S. H., Spann, R. A., Münzberg, H., Yu, S., Albaugh, V. L., He, Y., Berthoud, H., & Morrison, C. D. (2021) · Nutrients · doi:10.3390/nu13114103 · Cited by 35 · see citing works

Role of glucose-6-phosphate and xylulose-5-phosphate in the regulation of glucose-stimulated gene expression in the pancreatic β cell line, INS-1E

Iizuka, K., Wu, W., Horikawa, Y., & Takeda, J. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0413 · Cited by 33 · see citing works

Inducible Loss of the Aryl Hydrocarbon Receptor Activates Perigonadal White Fat Respiration and Brown Fat Thermogenesis via Fibroblast Growth Factor 21

Girer, N. G., Carter, D., Bhattarai, N., Mustafa, M. G., Denner, L. A., Porter, C. C., & Elferink, C. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040950 · Cited by 31 · see citing works

Recent advances in understanding the role of adipocytokines during non-alcoholic fatty liver disease pathogenesis and their link with hepatokines

Panera, N., Corte, C. D., Crudele, A., Stronati, L., Nobili, V., & Alisi, A. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2016.1110485 · Cited by 31 · see citing works

High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components

Li, D., Fu, G., Tu, R., Jin, Z., & Zhang, D. (2019) · Microbial Cell Factories · doi:10.1186/s12934-019-1066-4 · Cited by 31 · see citing works

Fibroblast growth factor 21 as a potential master regulator in metabolic disorders

Velingkar, A., Vuree, S., Prabhakar, P. K., Kalashikam, R. R., Banerjee, A., & Kondeti, S. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00244.2022 · Cited by 32 · see citing works

Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion

Harris, L.-A. L. S., Smith, G. I., Mittendorfer, B., Eagon, J. C., Okunade, A. L., Patterson, B. W., & Klein, S. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01295 · Cited by 31 · see citing works

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

Iroz, A., Montagner, A., Benhamed, F., Levavasseur, F., Polizzi, A., Anthony, E., Régnier, M., Fouché, E., Lukowicz, C., Cauzac, M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.065 · Cited by 128 · see citing works

1562-P: Hepatic ChREBP-ß Overexpression Enhances Peripheral Glucose and Lipid Homeostasis Independently of FGF21

Hannou, S. A., Sargsyan, A., Tong, W., An, J., Newgard, C. B., Astapova, I. I., & Herman, M. A. (2023) · Diabetes · doi:10.2337/db23-1562-p · Cited by 1 · see citing works

Role of fibroblast growth factor-21 in glucose-lipid metabolism in mice adipocyte and hepatocyte

Li, K., Ling, L., & Yang, G. (2010) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2010.08.019

Regulation of FGF21 Gene Expression by Nutritional Signals and Physical Activity in vivo and in vitro

Hao, L., Ito, K., Wray, A. E., Sae‐tan, S., Lambert, J. D., & Ross, C. (2013) · The FASEB Journal · doi:10.1096/fasebj.27.1_supplement.865.8

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

Fisher, F. M., Kim, M., Doridot, L., Cunniff, J. C., Parker, T. S., Levine, D. M., Hellerstein, M. K., Hudgins, L. C., Maratos-Flier, E., & Herman, M. A. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2016.11.008 · Cited by 166 · see citing works