The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice
Open accessAbstract
Obesity and type 2 diabetes are characterized by subclinical inflammatory process. Changes in composition or modulation of the gut microbiota may play an important role in the obesity-associated inflammatory process. In the current study, we evaluated the effects of probiotics (Lactobacillus rhamnosus, L. acidophilus and Bifidobacterium bifidumi) on gut microbiota, changes in permeability, and insulin sensitivity and signaling in high-fat diet and control animals. More importantly, we investigated the effects of these gut modulations on hypothalamic control of food intake, and insulin and leptin signaling. Swiss mice were submitted to a high-fat diet (HFD) with probiotics or pair-feeding for 5 weeks. Metagenome analyses were performed on DNA samples from mouse feces. Blood was drawn to determine levels of glucose, insulin, LPS, cytokines and GLP-1. Liver, muscle, ileum and hypothalamus tissue proteins were analyzed by Western blotting and real-time polymerase chain reaction. In addition, liver and adipose tissues were analyzed using histology and immunohistochemistry. The HFD induced huge alterations in gut microbiota accompanied by increased intestinal permeability, LPS translocation and systemic low-grade inflammation, resulting in decreased glucose tolerance and hyperphagic behavior. All these obesity-related features were reversed by changes in the gut microbiota profile induced by probiotics. Probiotics also induced an improvement in hypothalamic insulin and leptin resistance. Our data demonstrate that the intestinal microbiome is a key modulator of inflammatory and metabolic pathways in both peripheral and central tissues. These findings shed light on probiotics as an important tool to prevent and treat patients with obesity and insulin resistance.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Treatment with probiotics can reverse intestinal flora dysbiosis and treat inflammatory responses in mice.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [16]
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–265 of 265
Probiotic supplementation affects IGF-1 and leptin levels in Nile tilapia hepatopancreatic tissue
Pacheco, R. S., Ferro, P. H. S., Pereira, M. O., Jesus, G. F. A., Borges, Y. V., Jatobá, A., Moreira, F., & Schleder, D. D. (2021) · Arquivo Brasileiro de Medicina Veterinária e Zootecnia · doi:10.1590/1678-4162-12339 · Cited by 4
Yulianto, W. A., Wulandari, W., & Pujimulyani, D. (2023) · Food Research · doi:10.26656/fr.2017.7(2).845 · Cited by 4
Sustainable materials and infrastructures for the food industry
Muhammad, D. R. A., Zaman, M. Z., & Ariyantoro, A. R. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90885-6.00010-7 · Cited by 4
Russo, M., Marquez, A., Andrada, E., Torres, S., Santacruz, A., Medina, R. B., & Gauffin-Cano, P. (2025) · Metabolites · doi:10.3390/metabo15070466 · Cited by 3
Li, S., Zheng, J., Yang, Z., He, J., Liu, H., Zhong, W., Huang, Y., Li, Z., Yang, M., Zhao, X., et al. (2025) · Animal nutrition · doi:10.1016/j.aninu.2025.03.021 · Cited by 3
Cho, M., Joung, H., Jang, H., Kim, Y.-W., Chu, J., Kwon, Y. J., Shin, C. H., Ha, J., & Lee, J. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10909-4 · Cited by 3
Updated Insights into Probiotic Interventions for Metabolic Syndrome: Mechanisms and Evidence
Chen, L., Tian, L., Zhang, Y., Shi, Y., Yuan, W., Zou, Y. L., Zhang, Q., Chen, M., & Zeng, P. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10554-x · Cited by 3
Liu, P., Zuo, J., Lu, H., Zhang, B., & Wu, C. (2025) · Veterinary Sciences · doi:10.3390/vetsci12050489 · Cited by 3
Rithi, A. T., Mitra, A., Banerjee, A., Ilanchoorian, D., Marotta, F., & Radhakrishnan, A. (2024) · Functional Food Science · doi:10.31989/ffs.v4i1.1271 · Cited by 31
Potential of Probiotics in the Management of Lung Cancer
Divyashri, G., Murthy, T. P. K., & Murahari, M. (2020) · Springer eBooks · doi:10.1007/978-981-15-8214-1_10 · Cited by 3
Gong, X., Chen, Y., Chen, C., Chen, C., & Zhang, X. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107147 · Cited by 2
Askarpour, M., Jahromi, B. N., Eskandari, M. H., Maghsoudi, Z., Famouri, M., Bedeltavana, A., & Hejazi, N. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70506 · Cited by 2
Habib, H. B., Omi, F. R., Biswas, S., Mita, M. A., Suhi, S., Zaman, S., Akhtar‐E‐Ekram, M., Saleh, M. A., & Uddin, M. S. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10639-7 · Cited by 2
Abenavoli, L., YOSYPENKO, K., YURCHYSHENA, Y., Savytska, M., Lazarieva, O., Shvets, Y. V., Scarlata, G. G. M., Lynchak, O. V., & Falalyeyeva, T. M. (2026) · Minerva Gastroenterology · doi:10.23736/s2724-5985.25.04054-9 · Cited by 3
Jiang, S., Meng, Q., Jiang, C., Lv, Y., Liu, L., Xie, R., Ya, F., & Gao, Q. (2026) · Food & Function · doi:10.1039/d5fo04882f · Cited by 3
Wen, F., Liu, X., Ding, K., Zhang, F., & Wang, J. (2022) · Veterinární Medicína · doi:10.17221/34/2021-vetmed · Cited by 2
Managing Glucose Homeostasis Through the Gut Microbiome
Weninger, S. N., Manley, A., & Duca, F. A. (2025) · Annual Review of Physiology · doi:10.1146/annurev-physiol-051524-094728 · Cited by 3
Saha, S., Alam, N. N., & Rahman, S. M. N. (2022) · Biomedicine · doi:10.51248/.v42i4.1359 · Cited by 2
Farida, E., Lestari, Y. N. A., Susilo, M. T., & Rachmawati, L. (2022) · Bookchapter Kesehatan Masyarakat Universitas Negeri Semarang · doi:10.15294/km.v1i2.75 · Cited by 2
High-fat Diet Induced Dysbiosis & Amelioration by Astaxanthin
Haasbroek, K., Takabe, W., Yagi, M., & Yonei, Y. (2019) · Rad Hrvatske akademije znanosti i umjetnosti Medicinske znanosti · doi:10.21857/9xn31crexy · Cited by 2
Ullah, H., Daglia, M., & Khan, H. Z. (2022) · Wiley eBooks · doi:10.1002/9781119746843.ch5 · Cited by 2
Immunomodulatory Potential of Lactobacillus acidophilus: Implications in Bone Health
Bhardwaj, A., Sapra, L., Verma, B., & Srivastava, R. K. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97063 · Cited by 1
Santos, B. P. D. S., & de Aguiar, L. L. (2024) · Revista Contemporânea · doi:10.56083/rcv4n10-108 · Cited by 1
A bibliometric and visual analysis of global gestational diabetes mellitus over the past 24 years
Sun, Y., Zhu, L.-M., Wei, C.-X., & Ren, Y.-J. (2025) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-025-01752-z · Cited by 1
Duan, X., Shi, H., Zhao, M., Jiang, Z., Zhang, J., Chen, X., Zhang, H., Hou, J., & Li, X. (2026) · International Dairy Journal · doi:10.1016/j.idairyj.2025.106545 · Cited by 1
Wang, H., Chen, Y., Guli, M., Li, Z., Li, Z., Xu, W., & Wu, Z. (2020) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2020.05.005 · Cited by 1
Okyere, S. K. (2022) · Current Functional Foods · doi:10.2174/2666862901666220107152746 · Cited by 1
Rajak, P., & Ghosh, A. (2022) · Biodiversitas Journal of Biological Diversity · doi:10.13057/biodiv/d230511 · Cited by 1
Probiotics as a Food Supplement: What are they and how do they Work?
(2023) · Journal of Nutrition Food Science and Technology · doi:10.47485/2834-7854.1032 · Cited by 1
Effect of Mixed Probiotics on Ovalbumin‐Induced Atopic Dermatitis in Juvenile Mice
Huang, J., Wang, X., Li, Q.-H., Zhang, P., Jing, Z., Zhang, J., Su, H., & Sun, X. (2024) · International Journal of Microbiology · doi:10.1155/2024/7172386 · Cited by 1
A pro-, pre- és szinbiotikumok hatása a szénhidrát-, illetve lipidanyagcserére
Tomasics, G., Schandl, L., Polyák, A., & Winkler, G. (2024) · Orvosi Hetilap · doi:10.1556/650.2024.33064 · Cited by 1
Predictive Lifestyle Markers for Efficacy of Cancer Immune Checkpoint Inhibitors: A Commentary
Sillah, A., Tykodi, S. S., Hall, E. T., Thompson, J. A., Watson, N. F., Lee, S. M., Bhatia, S., Veatch, J. R., Warner, J., Peters, U., et al. (2021) · Future Oncology · doi:10.2217/fon-2020-0730 · Cited by 1
Polyphenols and their antioxidant and nonantioxidant effects in health and disease
Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00030-x · Cited by 1
Liu, L., Cheng, B., Wen, Y. F., Jia, Y., Cheng, S., Liang, C., Chu, X., Ye, J., Yao, Y., Dai, X., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-113419/v1 · Cited by 1
Lin, Y., Huang, H., Lai, Y., Chen, J., Tien, H.-H., Chen, Y.-F., Chen, Y., & Huang, C. (2020) · doi:10.21203/rs.2.20237/v1 · Cited by 1
Probiotics in the Management of Diabetes
Mohi-ud-din, R., Mir, R. H., Farooq, S., Wani, T. U., Pottoo, F. H., Mohi-ud-din, A., & Bhat, Z. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-8444-9_4
Xiao, Z., Zang, X., Dai, Z., Ye, J., Zheng, Y., Yao, H., & Liu, L. (2023) · Research Square · doi:10.21203/rs.3.rs-2897242/v1
Consumo da casca de jabuticaba (Plinia cauliflora)
Filho, P. S. L. (2020) · doi:10.47749/t/unicamp.2020.1163324
Cox, A. J., West, N. P., & Cripps, A. W. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch19
A metagenomic overview of microbial diversity and their impact on human health
Moopantakath, J., Imchen, M., Sreevalsan, A., & Kumavath, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-98394-5.00001-8
The human microbiome as drug targets
Lim, P. P., Joseph, C., Parmar, I., Amudha, N. M., Roy, M., Varanasi, G. V. S. A., & Patankar, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15435-5.00015-3
Subclinical Infections and Their Influence on Feline Metabolic Health
Wang, Z. (2024) · International Journal of Molecular Veterinary Research · doi:10.5376/ijmvr.2024.14.0014
Korek, E., Kupsz, J., Graczyk, S., & Szymczak, B. (2023) · Biuletyn Głównej Biblioteki Lekarskiej · doi:10.2478/bgbl-2023-0048
Kumar, H., Dhanjal, D. S., Dhalaria, R., Kimta, N., Cimler, R., & Kuča, K. (2025) · International review of neurobiology · doi:10.1016/bs.irn.2025.04.005
Hisham, N. S., Zain, W. N. I. W. M., Khan, J., Hasani, N. A. H., & Al-Talib, H. I. (2025) · Asia-Pacific Journal of Molecular Biology and Biotechnology · doi:10.35118/apjmbb.2025.033.3.10
Ramirez-Olea, H., Barragán-Longoria, M. F., & Chávez-Santoscoy, R. A. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.107040
The Role of Probiotics in Migraine Management: A Review of Advances
李, 纳. (2025) · Advances in Clinical Medicine · doi:10.12677/acm.2025.15113269
Gut Microbiota–Leptin crosstalk in obesity and metabolic dysregulation
Singh, L. S., & Sharma, L. A. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100671 · Cited by 1
Nami, Y., Kafil, B., & Dehnad, A. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71295
Additional file 1 of Probiotics supplementation and insulin resistance: a systematic review
Salles, B. I. M., Cioffi, D., & Ferreira, S. R. G. (2020) · Figshare · doi:10.6084/m9.figshare.13225700
Judijanto, L. (2026) · European Journal of Medical and Health Research · doi:10.59324/ejmhr.2026.4(1).32
THE EFFECTS OF FERMENTED FOODS ON HUMAN HEALTH
Oktay, B. A., & Özbaş, Z. Y. (2020) · DergiPark (Istanbul University)
Microbiote intestinal, cancer du sein et métabolisme lipidique
Luu, T. H. (2018) · theses.fr (ABES) · doi:10.70675/5a95efcbzc6e9z41b8z84a5z058eda043638
Sadooghi, N., Sharif, A. M. S., Fard, S. R., Moghadam, S., & Minaeian, S. (2026) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2026.100308
Probiotics improve obesity development and modulate gut microbiota in rabbits and their offsprings
Bouaziz, A., Dib, A. L., Monnoye, M., Kadja, L., Espigares, E., & Gérard, P. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107344
Kılınç, G. E., & Söğüt, M. Ü. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71967
Chen, W., Liu, Q., Fu, J., Zhao, J., Huang, R., & He, Q. (2026) · Journal of Health Population and Nutrition · doi:10.1186/s41043-026-01368-w
Diané, A., Mu-u-min, R., & Al-Siddiqi, H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146424
Southwell, M., Faraco, M., Ruiz, M. J., Romanelli, A., & Sagües, M. F. (2026) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2026.107044
Metadata
- Authors
- Bagarolli, R. A., Tobar, N., Oliveira, A. G., Araújo, T. G., Carvalho, B. M., Rocha, G. Z., Vecina, J. F., Calisto, K., Guadagnini, D., Prada, P. O., Santos, A., Saad, S. T. O., & Saad, M. J. A.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade Estadual Paulista (Unesp) (BR)
- Universidade Federal de Pernambuco (BR)
- ORCID
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 50
- Pages
- 16-25
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2746430677
- Cited by
- 266
- References
- 68
- Citations by year
- 2026: 12 · 2025: 30 · 2024: 25 · 2023: 32 · 2022: 38 · 2021: 44 · 2020: 46 · 2019: 23 · 2018: 16
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- State University of Campinas (FAEPEX)
- CEPID (201307607-8)
- OCRC (Centro de Pesquisa em Obesidade e Comorbidades)
- INCT (Instituto Nacional de Ciência e Tecnologia de Obesidade e Diabetes) (573856/2008-7)
- FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) (2012/15009-0, 2016/07122-2)
- CAPES/CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- probiotics, gut microbiota, insulin sensitivity, insulin resistance, type 2 diabetes, obesity, high-fat diet, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium bifidum, intestinal permeability, lipopolysaccharide translocation, low-grade inflammation, leptin signaling, food intake regulation, glucose tolerance, glucagon-like peptide-1, pair feeding
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium bifidum, Animals, Appetite Regulation, Cell Membrane Permeability, Diabetes Mellitus, Type 2, Feces, Insulin Resistance, Intestinal Mucosa, Lactobacillus acidophilus, Liver, Male, Obesity, Random Allocation, Glucose Clamp Technique, Probiotics, Mice, Lacticaseibacillus rhamnosus, Adipose Tissue, White, Molecular Typing, Diet, High-Fat, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
