Cited by 45Peroxisome Proliferator-Activated ReceptorsEdible Oils Quality and AnalysisParaoxonase enzyme and polymorphisms

The Olive Constituent Oleuropein, as a PPARα Agonist, Markedly Reduces Serum Triglycerides

Open access
Malliou, Foteini, Andreadou, Ioanna, Gonzalez, Frank J., Lazou, Antigone, Xepapadaki, Eva, Vallianou, Ioanna, Lambrinidis, George, Mikros, Emmanuel +3 more·2018·The Journal of Nutritional Biochemistry

Abstract

Oleuropein (OLE), a main constituent of olive, exhibits antioxidant and hypolipidemic effects, while it reduces the infarct size in chow- and cholesterol-fed rabbits. Peroxisome proliferator-activated receptor α (PPARα) has essential roles in the control of lipid metabolism and energy homeostasis. This study focused on the mechanisms underlying the hypolipidemic activity of OLE and, specifically, on the role of PPARα activation in the OLE-induced effect. Theoretical approach using Molecular Docking Simulations and luciferase reporter gene assay indicated that OLE is a ligand of PPARα. The effect of OLE (100 mg/kg, p.o., per day, ×6 weeks) on serum triglyceride (TG) and cholesterol levels was also assessed in adult male wild-type and Ppara-null mice. Molecular Docking Simulations, Luciferase reporter gene assay and gene expression analysis indicated that OLE is a PPARα agonist that up-regulates several PPARα target genes in the liver. This effect was associated with a significant reduction of serum TG and cholesterol levels. In contrast, OLE had no effect in Ppara-null mice, indicating a direct involvement of PPARα in the OLE-induced serum TG and cholesterol reduction. Activation of hormone-sensitive lipase in the white adipose tissue (WAT) and the liver of wild-type mice and up-regulation of several hepatic factors involved in TG uptake, transport, metabolism and clearance may also contribute in the OLE-induced TG reduction. In summary, OLE has a beneficial effect on TG homeostasis via PPARα activation. OLE also activates the hormone sensitive lipase in the WAT and liver and up-regulates several hepatic genes with essential roles in TG homeostasis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jnutbio.2018.05.013

Cites

71 of 71 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Malliou, F., Andreadou, I., Gonzalez, F. J., Lazou, A., Xepapadaki, E., Vallianou, I., Lambrinidis, G., Mikros, E., Marselos, M., Skaltsounis, A.-L., & Konstandi, M.
Affiliations
  • University of Ioannina (GR)
  • National and Kapodistrian University of Athens (GR)
  • National Institutes of Health (US)
  • Aristotle University of Thessaloniki (GR)
  • University of Patras (GR)
Corresponding author
Konstandi, Maria
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
2018-09
Volume
59
Pages
17-28
ISSN
0955-2863 (ISSN-L)
OpenAlex
W2807428653
Cited by
45
References
71
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 11 · 2020: 5 · 2019: 6
FWCI
1.96
Type
journal article
Language
en
Open access
Locations
  • The Journal of Nutritional Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (ZIABC005708, ZIABC005562)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
oleuropein, serum triglycerides, hypolipidemic effect, PPARα target genes, hormone-sensitive lipase, white adipose tissue, hepatic lipid metabolism, cholesterol, PPARalpha-null mice, molecular docking
MeSH terms
Proprotein Convertase 9, Animals, Cells, Cultured, Homeostasis, Lipids, Luciferases, Male, Mice, Inbred Strains, Mice, Mutant Strains, Receptors, LDL, Triglycerides, Hepatocytes, Olea, Iridoids, PPAR alpha, Adipose Tissue, White, Iridoid Glucosides, Molecular Docking Simulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review