The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene
Open accessAbstract
Peroxisome proliferators are a diverse group of chemicals, including several hypolipidaemic drugs, that activate a nuclear hormone receptor termed the peroxisome proliferator activated receptor (PPAR). The peroxisomal enzyme acyl CoA oxidase (ACO) is the most widely used marker of peroxisome proliferator action. We have examined the 5' flanking region of the rat ACO gene for sequences that mediate the transcriptional effect of peroxisome proliferators and have identified an element located 570 bp upstream of the ACO gene that confers responsiveness to the hypolipidaemic peroxisome proliferator Wy-14,643. This peroxisome proliferator response element (PPRE) contains a direct repeat of the sequence motifs TGACCT and TGTCCT and binds PPAR. These data therefore indicate an important role of PPAR in mediating the action of peroxisome proliferators including the induction of ACO.
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PPARγ heterodimerizes with RXRs.
“PPAR␥ heterodimerizes with RXRs (Tugwood et al., 1992), and, during ligand activation, the PPAR/RXR heterodimer recruits coactivators and binds to sequence-specific PPAR response elements present in the promoter region of several target genes.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Tugwood et al., 1992
The Introduction and Discussion describe PPAR binding a response element in the rat ACO promoter. The Discussion mentions RXR only in comparing response-element sequences; it does not say that PPARγ heterodimerizes with RXRs. Searches for RXR heterodimerization and PPARγ found no passage addressing that claim. (LLM, conf=0.76)
Experimental — accuracy not yet measuredDuring ligand activation, the PPAR/RXR heterodimer recruits coactivators and binds to sequence-specific PPAR response elements present in the promoter region of several target genes.
“PPAR␥ heterodimerizes with RXRs (Tugwood et al., 1992), and, during ligand activation, the PPAR/RXR heterodimer recruits coactivators and binds to sequence-specific PPAR response elements present in the promoter region of several target genes.”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Tugwood et al., 1992
The citation is attached to the statement that PPARγ heterodimerizes with RXRs. The Discussion (page not available in our copy) describes PPAR binding a response element in the ACO promoter and separately mentions an RXR response element, but does not say that PPARγ heterodimerizes with RXR. Searches for heterodimerization and RXR partnership found no supporting passage; the later coactivator statement is not attached to this citation. (LLM, conf=0.75)
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Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719 · see citing works
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS
Berry, M. N., & Friend, D. S. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.43.3.506 · Cited by 4,407 · see citing works
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works
Self-citationUmesono, K., Murakami, K. K., Thompson, C. C., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(91)90020-y · Cited by 1,688 · see citing works
Lazarow, P. B., & de Duve, C. (1976) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.73.6.2043 · Cited by 1,044 · see citing works
Nuclear receptors enhance our understanding of transcription regulation
Green, S., & Chambon, P. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90108-4 · Cited by 1,042 · see citing works
Self-citationIdentification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene
de Thé, H., Vivanco, M. D., Tiollais, P., Stunnenberg, H. G., & Dejean, A. (1990) · Nature · doi:10.1038/343177a0 · Cited by 991 · see citing works
Reddy, J. K., Lalvvai, N. D., & Farber, E. (1983) · Critical Reviews in Toxicology · doi:10.3109/10408448309029317 · Cited by 879 · see citing works
Steroid Receptor Family: Structure and Functions
Carson, M. A., Schrader, W. T., & O’Malley, B. W. (1990) · Endocrine Reviews · doi:10.1210/edrv-11-2-201 · Cited by 811 · see citing works
Klein‐Hitpaß, L., Schorpp, M., Wagner, U. G., & Ryffel, G. U. (1986) · Cell · doi:10.1016/0092-8674(86)90705-1 · Cited by 720 · see citing works
Matsuura, Y., Possee, R. D., Overton, H. A., & Bishop, D. H. L. (1987) · Journal of General Virology · doi:10.1099/0022-1317-68-5-1233 · Cited by 672 · see citing works
A versatilein vivoandin vitroeukaryotic expression vector for protein engineering
Green, S., Issemann, I., & Sheer, E. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.1.369 · Cited by 659 · see citing works
Self-citationMangelsdorf, D. J., Umesono, K., Kliewer, S. A., Borgmeyer, U., Ong, E. S., & Evans, R. M. (1991) · Cell · doi:10.1016/0092-8674(81)90018-0 · Cited by 647 · see citing works
Kumar, V., Green, S., Staub, A., & Chambon, P. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04489.x · Cited by 529 · see citing works
Self-citationBiochemical Mechanisms Of Induction Of Hepatic Peroxisome Proliferation
Lock, E. A., Mitchell, A. M., & Elcombe, C. R. (1989) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.29.040189.001045 · Cited by 424 · see citing works
Marsman, D. S., Cattley, R. C., Conway, J. G., & Popp, J. A. (1988) · PubMed · Cited by 353 · see citing works
Reddy, J. K., Goel, S. K., Nemali, M. R., Carrino, J. J., Laffler, T. G., Reddy, M. K., Sperbeck, S. J., Osumi, T., Hashimoto, T., & Lalwani, N. D. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.6.1747 · Cited by 323 · see citing works
Hardwick, J. P., Song, B. J., Huberman, E., & Gonzalez, F. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75857-8 · Cited by 312 · see citing works
Martinez, E., Givel, F., & Wahli, W. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02706.x · Cited by 268 · see citing works
Kasai, H., Okada, Y., Nishimura, S., Rao, M. S. R., & Reddy, J. K. (1989) · PubMed · Cited by 230 · see citing works
Osumi, T., Wen, J., & Hashimoto, T. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91645-s · Cited by 197 · see citing works
Peroxisome proliferation and nongenotoxic carcinogenesis: Commentary on a symposium*1
Moody, D. E. (1991) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(91)90108-g · Cited by 182 · see citing works
Orton, T. C., & Parker, G. L. (1982) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)07846-8 · Cited by 161 · see citing works
Hijikata, M., Wen, J., Osumi, T., & Hashimoto, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39605-x · Cited by 130 · see citing works
Cattley, R. C., & Popp, J. A. (1989) · PubMed · Cited by 123 · see citing works
Kimura, S., Hanioka, N., MATSUNAGA, E., & Gonzalez, F. J. (1989) · DNA · doi:10.1089/dna.1.1989.8.503 · Cited by 122 · see citing works
Isolation and structural characterization of the rat acyl-CoA oxidase gene.
Osumi, T., Ishii, N., Miyazawa, S., & Hashimoto, T. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47540-0 · Cited by 102 · see citing works
Factors influencing peroxisome proliferation in cultured rat hepatocytes
Mitchell, A. M., Bridges, J. W., & Elcombe, C. R. (1984) · Archives of Toxicology · doi:10.1007/bf00341018 · Cited by 100 · see citing works
Ishii, N., Hijikata, M., Osumi, T., & Hashimoto, T. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47541-2 · Cited by 73 · see citing works
Flagged first, then by citations
3 of the 33 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Lazarow,P.B. and de Duve,C. (1976) Proc. Natl. Acad. Sci. USA, 73, 2043-2046.
- Reddy,J.K. Goel,S.K., Nemali,M.R., Carrino,J.J., Laffler,T.G., Reddy,M.K., Sperbeck,S.J., Osumi,T., Hashimoto,T., Lalwani,N.D. and Rao,M.S. (1986) Proc. Natl. Acad. Sci. USA, 83, 1747-1751.
- Ausubel,F.M., Brent,R., Kingston,R.E., Moore,D.D., Seidman,J.G., Smith,J.A. and Struhl,K. (eds) (1990) Current Protocols in Molecular Biology. Wiley, New York.
- Green,S. (1991) Biochem. Pharmacol., in press.
Cited by
Sorted by citations
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism
Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,079 · see citing works
(1998) · PubMed · Cited by 2,737 · see citing works
The mechanisms of action of PPARs
Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works
Kliewer, S. A., Umesono, K., Noonan, D. J., Heyman, R. A., & Evans, R. M. (1992) · Nature · doi:10.1038/358771a0 · Cited by 1,741 · see citing works
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,655 · see citing works
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504 · see citing works
Kliewer, S. A., FORMAN, B. M., Blumberg, B., Ong, E. S., Borgmeyer, U., Mangelsdorf, D. J., Umesono, K., & Evans, R. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7355 · Cited by 1,400 · see citing works
Induction of phase I, II and III drug metabolism/transport by xenobiotics
Xu, C., Li, C. Y.-T., & Kong, A. T. (2005) · Archives of Pharmacal Research · doi:10.1007/bf02977789 · Cited by 1,272 · see citing works
Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216 · see citing works
The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene
Lluis Fajas, A., Auboeuf, D., Raspé, E., Schoonjans, K., Lefebvre, A., Saladin, R., Najib, J., Laville, M., Fruchart, J., Deeb, S. S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18779 · Cited by 1,188 · see citing works
Schoonjans, K., Peinado‐Onsurbe, J., Lefebvre, A. M., Heyman, R. A., Briggs, M., Deeb, S., Staels, B., & Auwerx, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00918.x · Cited by 1,173 · see citing works
Lillycrop, K. A., Phillips, E. S., Jackson, A. A., Hanson, M. A., & Burdge, G. C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1382 · Cited by 1,139 · see citing works
Molecular Cues to Implantation
Dey, S. K., Lim, H. J., Das, S. K., Reese, J., Paria, B. C., Daikoku, T., & Wang, H. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0020 · Cited by 1,105 · see citing works
Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089 · see citing works
PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs
He, T., Chan, T. A.-T., Vogelstein, B., & Kinzler, K. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81664-5 · Cited by 1,083 · see citing works
Schoonjans, K., Staels, B., & Auwerx, J. H. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00066-5 · Cited by 1,047 · see citing works
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
Michalik, L., Auwerx, J. H., Berger, J. P., Chatterjee, K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O’Rahilly, S., et al. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.5 · Cited by 997 · see citing works
Keller, H., Dreyer, C., Medin, J. A., Mahfoudi, A., Ozato, K., & Wahli, W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.6.2160 · Cited by 948 · see citing works
Emerging roles of PPARS in inflammation and immunity
Daynes, R. A., & Jones, D. C. (2002) · Nature reviews. Immunology · doi:10.1038/nri912 · Cited by 922 · see citing works
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
Bougarne, N., Weyers, B., Desmet, S. J., Deckers, J., Ray, D. W., Staels, B., & De Bosscher, K. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00064 · Cited by 898 · see citing works
Retinoids in Embryonal Development
Ross, S. A., McCaffery, P. J. A., Dräger, U. C., & Luca, L. M. D. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1021 · Cited by 866 · see citing works
Orphan Nuclear Receptors: From Gene to Function
Giguère, V. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0378 · Cited by 848 · see citing works
Multiplicity generates diversity in the retinoic acid signalling pathways
Leid, M., Kastner, P., & Chambon, P. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90014-z · Cited by 821 · see citing works
Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*
Glass, C. K. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-391 · Cited by 820 · see citing works
Regulation of energy metabolism by long-chain fatty acids
Nakamura, M., Yudell, B. E., & Loor, J. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 830 · see citing works
Lemberger, T., Desvergne, B., & Wahli, W. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.335 · Cited by 704 · see citing works
Carson, D. D., Bagchi, I. C., Dey, S., Enders, A. C., Fazleabas, A. T., Lessey, B. A., & Yoshinaga, K. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9767 · Cited by 690 · see citing works
Integrated physiology and systems biology of PPARα
Kersten, S. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.002 · Cited by 679 · see citing works
Peroxisome proliferator-activated receptors in inflammation control
Delerive, P., Fruchart, J., & Staels, B. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1690453 · Cited by 755 · see citing works
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdeltaPreprint
Lim, H. J., Gupta, R. A., Ma, W., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., & Dey, S. K. (1999) · Genes & Development · doi:10.1101/gad.13.12.1561 · Cited by 586 · see citing works
Inflammatory processes in Alzheimer's disease
Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782 · see citing works
Gulick, T., Cresci, S., Caira, T., Moore, D. D., & Kelly, D. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11012 · Cited by 560 · see citing works
Mirza, A. Z., Althagafi, I. I., & Shamshad, H. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.067 · Cited by 555 · see citing works
Yoon, M. J., Lee, G. Y., Chung, J.-J., Ahn, Y. H., Hong, S. H., & Kim, J. B. (2006) · Diabetes · doi:10.2337/db05-1322 · Cited by 546 · see citing works
Control of Macrophage Activation and Function by PPARs
Chawla, A. (2010) · Circulation Research · doi:10.1161/circresaha.110.216523 · Cited by 531 · see citing works
Kunau, W. H. (1995) · Progress in Lipid Research · doi:10.1016/0163-7827(95)00011-9 · Cited by 506 · see citing works
Wolfrum, C., Borrmann, C. M., Börchers, T., & Spener, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051619898 · Cited by 503 · see citing works
Delerive, P., Martin‐Nizard, F., Chinetti, G., Trottein, F., Fruchart, J., Najïb, J., Duriez, P., & Staels, B. (1999) · Circulation Research · doi:10.1161/01.res.85.5.394 · Cited by 502 · see citing works
Baes, M. I., Gulick, T., Choi, H.-S., Martinoli, M., Simha, D., & Moore, D. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1544 · Cited by 492 · see citing works
Central Role of Pparα–Dependent Hepatic Lipid Turnover in Dietary Steatohepatitis in Mice
Ip, E., Farrell, G. C., Robertson, G., Hall, P., Kirsch, R., & Leclercq, I. (2003) · Hepatology · doi:10.1053/jhep.2003.50307 · Cited by 476 · see citing works
Differential activation of adipogenesis by multiple PPAR isoforms.Preprint
Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 474 · see citing works
Nuclear Receptor Signaling and Cardiac Energetics
Huss, J. M., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000141774.29937.e3 · Cited by 472 · see citing works
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80025-5 · Cited by 459 · see citing works
Gervois, P. P., Fruchart, J., Delerive, P., & Staels, B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004045200 · Cited by 457 · see citing works
Peroxisome proliferator activated receptor-alpha expression in human liver.
Palmer, C. N., Hsu, M. H., Griffin, K. J., Raucy, J. L., & Johnson, E. F. (1998) · PubMed · Cited by 448 · see citing works
N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
Jump, D. B. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282ffaf6a · Cited by 443 · see citing works
Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
Tateishi, K., Okada, Y., Kallin, E. M., & Zhang, Y. (2009) · Nature · doi:10.1038/nature07777 · Cited by 442 · see citing works
Neuroinflammatory processes in Alzheimer’s disease
Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0438-z · Cited by 433 · see citing works
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms
Sastre, M., Klockgether, T., & Heneka, M. T. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.014 · Cited by 426 · see citing works
Bishop‐Bailey, D., & Hla, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17042 · Cited by 424 · see citing works
Peroxisome Proliferator Activated Receptor-α Expression in Human Liver
Palmer, C. N. A., Hsu, M.-H., Griffin, K. J., Raucy, J. L., & Johnson, E. F. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.14 · Cited by 416 · see citing works
Protein Import into Peroxisomes and Biogenesis of the Organelle
Subramani, S. E. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.002305 · Cited by 416 · see citing works
Staels, B., Vu-Dac, N., Kosykh, V. A., Saladin, R., Fruchart, J. C., Dallongeville, J., & Auwerx, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117717 · Cited by 410 · see citing works
Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3949 · Cited by 410 · see citing works
Greene, M. E., Blumberg, B., McBride, O. W., Yi, H., Kronquist, K. E., Kwan, K. W., Hsieh, L., Greene, G. L., & Nimer, S. D. (1995) · Europe PMC (PubMed Central) · Cited by 399 · see citing works
Vu‐Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Fruchart, J., Staels, B., & Auwerx, J. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118118 · Cited by 397 · see citing works
Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα
Moya-Camarena, S. Y., Heuvel, J. P. V., Blanchard, S. G., Leesnitzer, L. M., & Belury, M. A. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33384-8 · Cited by 396 · see citing works
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
Kersten, S., & Stienstra, R. (2017) · Biochimie · doi:10.1016/j.biochi.2016.12.019 · Cited by 397 · see citing works
Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.
Gearing, K. L., Göttlicher, M., Teboul, M., Widmark, E., & Gustafsson, J.-Α. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1440 · Cited by 395 · see citing works
Schoonjans, K., 渡辺, 光., Suzuki, H., Mahfoudi, A., Krey, G. D., Wahli, W., Grimaldi, P. A., Staels, B., Yamamoto, T. T., & Auwerx, J. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19269 · Cited by 395 · see citing works
Peroxisome proliferator-activated receptors: insight into multiple cellular functions
Escher, P., & Wahli, W. (2000) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(99)00231-6 · Cited by 491 · see citing works
PPARα: Energy Combustion, Hypolipidemia, Inflammation and Cancer
Pyper, S. R., Viswakarma, N., Yu, S., & Reddy, J. K. (2010) · Nuclear Receptor Signaling · doi:10.1621/nrs.08002 · Cited by 381 · see citing works
Rodríguez, J. C., Gil‐Gómez, G., Hegardt, F. G., & Haro, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32234-2 · Cited by 378 · see citing works
Juge-Aubry, C. E., Pernin, A., Favez, T., Burger, A., Wahli, W., Meier, C. A., & Desvergne, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25252 · Cited by 377 · see citing works
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis
Hegardt, F. G. (1999) · Biochemical Journal · doi:10.1042/bj3380569 · Cited by 375 · see citing works
Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503839103 · Cited by 373 · see citing works
Zhu, Y., Alvares, K., Huang, Q. M., Rao, M. S. R., & Reddy, J. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74184-2 · Cited by 374 · see citing works
Peroxisome Proliferator-Activated Receptors
Schiffrin, E. L., Amiri, F., Benkirane, K., Iglarz, M., & Diep, Q. N. (2003) · Hypertension · doi:10.1161/01.hyp.0000084370.74777.b6 · Cited by 369 · see citing works
Omiecinski, C. J., Heuvel, J. P. V., Perdew, G. H., & Peters, J. M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq338 · Cited by 368 · see citing works
Cloning of a Protein That Mediates Transcriptional Effects of Fatty Acids in Preadipocytes
Amri, E., Bonino, F., Ailhaud, G. P., Abumrad, N. A., & Grimaldi, P. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2367 · Cited by 368 · see citing works
Conjugated linoleic acid modulates hepatic lipid composition in mice
Belury, M. A., & Kempa-Steczko, A. (1997) · Lipids · doi:10.1007/s11745-997-0025-0 · Cited by 367 · see citing works
Peroxisome proliferator‐activated receptors in the cardiovascular system
Bishop‐Bailey, D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703149 · Cited by 358 · see citing works
Cytoplasmic fatty acid-binding proteins: Their structure and genes
Veerkamp, J. H., & Maatman, R. G. H. J. (1995) · Progress in Lipid Research · doi:10.1016/0163-7827(94)00005-7 · Cited by 355 · see citing works
Xenobiotic-inducible Transcription of Cytochrome P450 Genes
Denison, M. S., & Whitlock, J. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18175 · Cited by 354 · see citing works
IJpenberg, A., Jeannin, E., Wahli, W., & Desvergne, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20108 · Cited by 352 · see citing works
Hypoxia-inducible factor 2 regulates hepatic lipid metabolism
Rankin, E. B., Rha, J., Selak, M. A., Unger, T. L., Keith, B., Liu, Q., & Haase, V. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00200-09 · Cited by 338 · see citing works
Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.
Hertz, R., Bishara-Shieban, J., & Bar‐Tana, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13470 · Cited by 339 · see citing works
Yoon, M. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.02.004 · Cited by 336 · see citing works
Lemberger, T., Saladin, R., Vázquez‐Carrera, M., Assimacopoulos, F., Staels, B., Desvergne, B., Wahli, W., & Auwerx, J. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1764 · Cited by 329 · see citing works
Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & Heneka, M. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1569-12.2012 · Cited by 326 · see citing works
Zhou, J., Wang, K.-C., Wu, W., Subramaniam, S., Shyy, J. Y.-J., Chiu, J., Li, J. Y.-S., & Chien, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107052108 · Cited by 325 · see citing works
Ashby, J., Brady, A. M., Elcombe, C. R., ELLIOTT, B. M., Ishmael, J., Odum, J., Tugwood, J. D., Kettle, S., & Purchase, I. F. H. (1994) · Human & Experimental Toxicology · doi:10.1177/096032719401300201 · Cited by 312 · see citing works
Self-citationConjugated linoleic acid and obesity control: efficacy and mechanisms
Wang, Y. W., & Jones, P. J. H. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802641 · Cited by 312 · see citing works
Muerhoff, A. S., Griffin, K. J., & Johnson, E. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41738-3 · Cited by 311 · see citing works
Kondo, T., Kishi, M., Fushimi, T., & Kaga, T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf900470c · Cited by 301 · see citing works
The cytochrome P450 4 (CYP4) family
Simpson, A. E. C. M. (1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(96)00246-7 · Cited by 298 · see citing works
Peroxisome proliferator-activated receptors (PPARs): Novel therapeutic targets in renal disease
Guan, Y., & Breyer, M. D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00766.x · Cited by 292 · see citing works
Peroxisome Proliferators Enhance Cyclooxygenase-2 Expression in Epithelial Cells
Meade, E. A., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8328 · Cited by 293 · see citing works
Fatty Acid Flip-Flop in Phospholipid Bilayers Is Extremely Fast
Kamp, F., Zakim, D., Zhang, F., Noy, N., & Hamilton, J. A. (1995) · Biochemistry · doi:10.1021/bi00037a034 · Cited by 292 · see citing works
Nuclear Receptors and Their Selective Pharmacologic Modulators
Burris, T. P., Solt, L. A., Wang, Y., Crumbley, C., Banerjee, S., Griffett, K., Lundåsen, T., Hughes, T., & Kojetin, D. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006833 · Cited by 285 · see citing works
Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G. D., & Wahli, W. (1993) · Biology of the Cell · doi:10.1016/s0248-4900(05)80176-5 · Cited by 284 · see citing works
DiRenzo, J., Söderström, M., Kurokawa, R., Ogliastro, M.-H., Ricote, M., Ingrey, S., Hörlein, A., Rosenfeld, M. G., & Glass, C. K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2166 · Cited by 281 · see citing works
Novel Sequence Determinants in Peroxisome Proliferator Signaling
Palmer, C. N. A., Hsu, M., Griffin, K. J., & Johnson, E. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.27.16114 · Cited by 283 · see citing works
Hepatic peroxisome proliferation in rodents and its significance for humans
Bentley, P., Calder, I. C., Elcombe, C. R., GRASSO, P., Stringer, D. A., & Wiegand, H.-J. (1993) · Food and Chemical Toxicology · doi:10.1016/0278-6915(93)90225-n · Cited by 271 · see citing works
Frohnert, B. I., Hui, T. Y., & Bernlohr, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.3970 · Cited by 265 · see citing works
Parhami, F., Jackson, S. M., Tintut, Y., Le, V. L., Balucan, J. P., Territo, M., & Demer, L. L. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.12.2067 · Cited by 259 · see citing works
Girnun, G. D., Domann, F. E., Moore, S. A., & Robbins, M. E. C. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0020 · Cited by 258 · see citing works
Mechanisms Mediating the Regulation of Peroxisomal Fatty Acid Beta-Oxidation by PPARα
Tahri-Joutey, M., Andreoletti, P., Surapureddi, S., Nasser, B., Cherkaoui‐Malki, M., & Latruffe, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168969 · Cited by 258 · see citing works
Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression.
Miller, C. W., & Ntambi, J. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9443 · Cited by 253 · see citing works
Ward, J. M., Peters, J. M., Perella, C. M., & Gonzalez, F. J. (1998) · Toxicologic Pathology · doi:10.1177/019262339802600208 · Cited by 249 · see citing works
- Authors
- Tugwood, J. D., Issemann, I., Anderson, R. G., Bundell, K. R., McPheat, W. L., & Green, S.
- Venue
- The EMBO Journal
- Published
- 1992-02-01
- Volume
- 11
- Issue
- 2
- Pages
- 433-439
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC556472
- OpenAlex
- W98247596
- Cited by
- 895
- References
- 33
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 16 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 24 · 2013: 27 · 2012: 16
- FWCI
- 20.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- peroxisome proliferator-activated receptors, peroxisome proliferators, acyl-CoA oxidase, peroxisome proliferator response element, 5'-flanking region, transcriptional regulation, Wy-14,643, hypolipidaemic drugs
- MeSH terms
- Animals, Anticholesteremic Agents, Base Sequence, Binding Sites, Cell Line, Humans, Kinetics, Methylation, Microbodies, Molecular Sequence Data, Oligodeoxyribonucleotides, Oxidoreductases, Plasmids, Promoter Regions, Genetic, Pyrimidines, Repetitive Sequences, Nucleic Acid, Transfection, Chloramphenicol O-Acetyltransferase, Baculoviridae, Acyl-CoA Oxidase, Fatty Acid Desaturases, Rats
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