Peroxisome proliferator activated receptor alpha activation decreases inflammatory and destructive responses in osteoarthritic cartilage

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

Farndale, R. W., Buttle, D. J., & Barrett, A. J. (1986) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(86)90306-5 · Cited by 3,313 · see citing works

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips

Mankin, H. J., DORFMAN, H., Lippiello, L., & Zarins, A. (1971) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197153030-00009 · Cited by 1,969 · see citing works

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-arthritic Human Hips. II: Correlation of Morphology with Biochemical and Metabolic Data

Charalambous, C. P. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5451-8_97 · Cited by 1,845 · see citing works

The PPARα–leukotriene B4 pathway to inflammation control

Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345 · see citing works

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

Krey, G. D., Braissant, O., L’Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., & Wahli, W. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.6.0007 · Cited by 1,221 · see citing works

Osteoarthritis

Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179 · see citing works

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., & Kliewer, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3406 · Cited by 1,110 · see citing works

Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Tedgui, A., Haegeman, G., & Staels, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32048 · Cited by 1,089 · see citing works

Biochemical and Metabolic Abnormalities in Articular Cartilage from Osteo-Arthritic Human Hips

Mankin, H. J., & Lippiello, L. (1970) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197052030-00002 · Cited by 854 · see citing works

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

Lemberger, T., Desvergne, B., & Wahli, W. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.335 · Cited by 704 · see citing works

The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis

Goldring, S. R., & Goldring, M. B. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000144854.66565.8f · Cited by 655 · see citing works

NF-κB Signaling: Multiple Angles to Target OA

Marcu, K. B., Otero, M., Olivotto, E., Borzı̀, R. M., & Goldring, M. B. (2010) · Current Drug Targets · doi:10.2174/138945010791011938 · Cited by 567 · see citing works

Cartilage in normal and osteoarthritis conditions

Martel‐Pelletier, J., Boileau, C., Pelletier, J., & Roughley, P. J. (2008) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2008.02.001 · Cited by 556 · see citing works

Peroxisome Proliferator-Activated Receptor Activators Inhibit Thrombin-Induced Endothelin-1 Production in Human Vascular Endothelial Cells by Inhibiting the Activator Protein-1 Signaling Pathway

Delerive, P., Martin‐Nizard, F., Chinetti, G., Trottein, F., Fruchart, J., Najïb, J., Duriez, P., & Staels, B. (1999) · Circulation Research · doi:10.1161/01.res.85.5.394 · Cited by 502 · see citing works

Association between weight or body mass index and hand osteoarthritis: a systematic review

Yusuf, E., Nelissen, R. G. H. H., Ioan‐Facsinay, A., Stojanovic-Susulic, V., DeGroot, J., van Osch, G. J. V. M., Middeldorp, S., Huizinga, T. W. J., & Kloppenburg, M. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.106930 · Cited by 445 · see citing works

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

Clockaerts, S., Bastiaansen-Jenniskens, Y. M., Runhaar, J., van Osch, G. J. V. M., Offel, J. F. V., Verhaar, J. A. N., Clerck, L. S. D., & Somville, J. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.03.014 · Cited by 433 · see citing works

Glucosamine inhibits IL-1β-induced NFκB activation in human osteoarthritic chondrocytes

Largo, R., Alvarez-Soria, M. A., Dı́ez-Ortego, I., Calvo, E., Sánchez‐Pernaute, O., Egido, J., & Herrero‐Beaumont, G. (2003) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(03)00028-1 · Cited by 386 · see citing works

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

McCoy, J. M., Wicks, J. R., & Audoly, L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15528 · Cited by 360 · see citing works

TNF-induced structural joint damage is mediated by IL-1

Zwerina, J., Redlich, K., Polzer, K., Joosten, L., Krönke, G., Distler, J., Hess, A., Pundt, N., Pap, T., Hoffmann, O., et al. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0610812104 · Cited by 322 · see citing works

The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

McCoy, J. M., Wicks, J. R., & Audoly, L. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215528 · Cited by 320 · see citing works

Vascular pathology and osteoarthritis

Findlay, D. M. (2007) · Rheumatology · doi:10.1093/rheumatology/kem191 · Cited by 304 · see citing works

Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1

Kamei, D., Yamakawa, K., Takegoshi, Y., Mikami-Nakanishi, M., Nakatani, Y., Oh‐ishi, S., Yasui, H., Azuma, Y., Hirasawa, N., Ohuchi, K., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400199200 · Cited by 278 · see citing works

Metalloproteases and inhibitors in arthritic diseases

Martel‐Pelletier, J., Welsch, D. J., & Pelletier, J. (2001) · Best Practice & Research Clinical Rheumatology · doi:10.1053/berh.2001.0195 · Cited by 270 · see citing works

Ligand Selectivity of the Peroxisome Proliferator-Activated Receptor α

Lin, Q., Ruuska, S. E., Shaw, N. S., Dong, D., & Noy, N. (1999) · Biochemistry · doi:10.1021/bi9816094 · Cited by 263 · see citing works

Nitric oxide in inflammation and pain associated with osteoarthritis

Abramson, S. B. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2463 · Cited by 232 · see citing works

PPARα in atherosclerosis and inflammation

Zandbergen, F. J., & Plutzky, J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.04.021 · Cited by 215 · see citing works

Peroxisome Proliferator-Activated Receptor α Agonists as Therapy for Autoimmune Disease

Lovett‐Racke, A. E., Hussain, R. Z., Northrop, S. C., Choy, J., Rocchini, A., Matthes, L., Chavis, J. A., Diab, A., Drew, P. D., & Racke, M. K. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5790 · Cited by 207 · see citing works

Is progressive osteoarthritis an atheromatous vascular disease?

Conaghan, P. G., Vanharanta, H., & Dieppe, P. A. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.039263 · Cited by 207 · see citing works

Peroxisome Proliferator-Activated Receptor α Protects against Obesity-Induced Hepatic Inflammation

Stienstra, R., Mandard, S., Patsouris, D., Maass, C., Kersten, S., & Müller, M. M. (2007) · Endocrinology · doi:10.1210/en.2007-0014 · Cited by 191 · see citing works

Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis

Zainal, Z., Longman, A. J., Hurst, S., Duggan, K., Caterson, B., Hughes, C., & Harwood, J. L. (2009) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.12.009 · Cited by 141 · see citing works

Evidence for the Presence of Peroxisome Proliferator-activated Receptor (PPAR) α and γ and Retinoid Z Receptor in Cartilage

Bordji, K., Grillasca, J., Gouze, J.-N., Magdalou, J., Schohn, H., Keller, J., Bianchi, A., Dauça, M., Netter, P., & Terlain, B. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.12243 · Cited by 134 · see citing works

Increased Matrix Metalloproteinase-13 Production With Aging by Human Articular Chondrocytes in Response to Catabolic Stimuli

Forsyth, C. B., Cole, A. A., Murphy, G., Bienias, J. L., Im, H.-J., & Loeser, R. F. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.9.1118 · Cited by 125 · see citing works

Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis.

Okamoto, H., Iwamoto, T., Kotake, S., Momohara, S., Yamanaka, H., & Kamatani, N. (2005) · PubMed · Cited by 113 · see citing works

Activation of Peroxisome Proliferator-activated Receptor γ Inhibits Interleukin-1β-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1

Cheng, S., Afif, H., Martel‐Pelletier, J., Pelletier, J., Li, X., Farrajota, K., Lavigne, M. J. F., & Fahmi, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402828200 · Cited by 112 · see citing works

Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study

Davies-Tuck, M. L., Hanna, F. S., Davis, S. R., Bell, R. J., Davison, S. L., Wluka, A. E., Adams, J., & Cicuttini, F. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2873 · Cited by 112 · see citing works

Vascular mechanisms in osteoarthritis

Ghosh, P. B., & Cheras, P. A. (2001) · Best Practice & Research Clinical Rheumatology · doi:10.1053/berh.2001.0188 · Cited by 98 · see citing works

Regional differences in chondrocyte metabolism in osteoarthritis: A detailed analysis by laser capture microdissection

Fukui, N., Ikeda, Y., Ohnuki, T., Tanaka, N., Hikita, A., Mitomi, H., Mori, T., Juji, T., Katsuragawa, Y., Yamamoto, S., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23175 · Cited by 87 · see citing works

Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes

Afif, H., Benderdour, M., Endam, L. M., Martel‐Pelletier, J., Pelletier, J., Duval, N., & Fahmi, H. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2151 · Cited by 84 · see citing works

Fibrate Therapy

Remick, J. S., WEINTRAUB, H. S., Setton, R. A., Offenbacher, J., Fisher, E. A. A., & Schwartzbard, A. Z. (2008) · Cardiology in Review · doi:10.1097/crd.0b013e31816b43d3 · Cited by 83 · see citing works

THE ROLE OF ENDOGENOUS AND EXOGENOUS LIGANDS FOR THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (PPAR-α) IN THE REGULATION OF INFLAMMATION IN MACROPHAGES

Crisafulli, C., & Cuzzocrea, S. (2009) · Shock · doi:10.1097/shk.0b013e31818bbad6 · Cited by 74 · see citing works

PPARα attenuates the proinflammatory response in activated mesangial cells

Kono, K., Kamijo, Y., Hora, K., Takahashi, K., Higuchi, M., Kiyosawa, K., Shigematsu, H., Gonzalez, F. J., & Aoyama, T. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00484.2007 · Cited by 53 · see citing works

Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression

Goldring, M., & Berenbaum, F. (1999) · Osteoarthritis and Cartilage · doi:10.1053/joca.1998.0219 · Cited by 45 · see citing works

Activation of the peroxisome proliferator–activated receptor α pathway potentiates interleukin‐1 receptor antagonist production in cytokine‐treated chondrocytes

François, M., Richette, P., Tsagris, L., Fitting, C., May, C. L., Benallaoua, M., Tahiri, K., & Corvol, M. T. (2006) · Arthritis & Rheumatism · doi:10.1002/art.21728 · Cited by 42 · see citing works

Peroxisome Proliferator-Activated Receptor-α Contributes to the Resolution of Inflammation after Renal Ischemia/Reperfusion Injury

Patel, N. S. A., Paola, R. D., Mazzon, E., Britti, D., Thiemermann, C., & Cuzzocrea, S. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.146191 · Cited by 40 · see citing works

Effect of PPAR Activators on Cytokine-Stimulated Cyclooxygenase-2 Expression in Human Colorectal Carcinoma Cells

Ikawa, H., Kameda, H., Kamitani, H., Baek, S. J., Nixon, J. B., Hsi, L. C., & Eling, T. E. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5233 · Cited by 39 · see citing works

Agonists of peroxisome proliferators-activated receptors (PPAR) α, β/δ or γ reduce transforming growth factor (TGF)-β-induced proteoglycans' production in chondrocytes

Poleni, P.-E., Bianchi, A., Etienne, S., Koufany, M., Sébillaud, S., Netter, P., Terlain, B. L., & Jouzeau, J. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.10.009 · Cited by 38 · see citing works

Peroxisome proliferator-activated receptors

Ziouzenkova, O., Perrey, S., Marx, N., Bacqueville, D., & Plutzky, J. (2002) · Current Atherosclerosis Reports · doi:10.1007/s11883-002-0063-x · Cited by 37 · see citing works

The Role of Analgesics and Intra-articular Injections in Disease Management

Harvey, W. F., & Hunter, D. J. (2008) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2008.05.006 · Cited by 34 · see citing works

Activation of PPARs α , β / δ , and γ Impairs TGF- β 1-Induced Collagens' Production and Modulates the TIMP-1/MMPs Balance in Three-Dimensional Cultured Chondrocytes

Poleni, P.-E., Etienne, S., Velot, É., Netter, P., & Bianchi, A. (2010) · PPAR Research · doi:10.1155/2010/635912 · Cited by 24 · see citing works

Influence of bisphosphonates on the production of pro-inflammatory cytokines by activated human articular chondrocytes

Offel, J. F. V., Dombrecht, E. J., Bridts, C. H., Schuerwegh, A. J., Ebo, D. G., Stevens, W. J., & Clerck, L. S. D. (2005) · Cytokine · doi:10.1016/j.cyto.2005.05.009 · Cited by 22 · see citing works

Ageing and Osteoarthritis.

Sacitharan, P. (2019) · Sub-cellular biochemistry · doi:10.1007/978-981-13-3681-2_6 · Cited by 113 · see citing works

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

Fahy, N., Melle, M. L. D. V., Lehmann, J., Wei, W., Grotenhuis, N., Farrell, E., van der Kraan, P. M., Murphy, M. J., Bastiaansen-Jenniskens, Y. M., & van Osch, G. J. V. M. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.05.021 · Cited by 270 · see citing works

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Nogueira-Recalde, U., Lorenzo-Gómez, I., Blanco, F. J., Loza, M. I., Grassi, D., Shirinsky, V., Shirinsky, I., Lotz, M., Robbins, P. D., Domínguez, E., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.049 · Cited by 155 · see citing works

The emerging role of fibroblast‐like synoviocytes‐mediated synovitis in osteoarthritis: An update

Han, D., Fang, Y., Tan, X., Jiang, H., Gong, X., Wang, X., Hong, W., Tu, J., & Wei, W. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15669 · Cited by 138 · see citing works

Knee pain and inflammation in the infrapatellar fat pad estimated by conventional and dynamic contrast-enhanced magnetic resonance imaging in obese patients with osteoarthritis: A cross-sectional study

Ballegaard, C., Riis, R., Bliddal, H., Christensen, R., Henriksen, M., Bartels, E. M., Lohmander, S. L., Hunter, D. J., Bouert, R., & Boesen, M. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.04.018 · Cited by 124 · see citing works

Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1β and inhibited by peroxisome proliferator activated receptor α agonist

Clockaerts, S., Bastiaansen-Jenniskens, Y. M., Feijt, C., Clerck, L. S. D., Verhaar, J. A. N., Zuurmond, A., Stojanovic-Susulic, V., Somville, J., Kloppenburg, M., & van Osch, G. J. V. M. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200688 · Cited by 101 · see citing works

Nuclear Receptors in Bone Physiology and Diseases

Imai, Y., Youn, M., Inoue, K., Takada, I., Kouzmenko, A., & Kato, S. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2012 · Cited by 89 · see citing works

PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis

Park, S., Baek, I., Ryu, J. H., Chun, C. H., & Jin, E. (2022) · Nature Communications · doi:10.1038/s41467-021-27738-y · Cited by 80 · see citing works

Chondrogenesis of Mesenchymal Stem Cells in an Osteochondral Environment Is Mediated by the Subchondral Bone

Melle, M. L. D. V., Narcisi, R., Kops, N., Koevoet, W. J. L. M., Bos, P. K., Murphy, M. J., Verhaar, J. A. N., van der Kraan, P. M., & van Osch, G. J. V. M. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0080 · Cited by 64 · see citing works

Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies

Dunn, S. L., Wilkinson, J. M., Crawford, A., Bunning, R. A. D., & Le Maitre, C. L. (2016) · Cannabis and Cannabinoid Research · doi:10.1089/can.2015.0001 · Cited by 62 · see citing works

Chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in a simulated osteochondral environment is hydrogel dependent

Room Ee16.14, D. M. 5., Melle, M. D. V.-V., Tihaya, M. S., Kops, N., Koevoet, W., Murphy, J., Verhaar, J., Alini, M., Eglin, D., & van Osch, G. (2014) · European Cells and Materials · doi:10.22203/ecm.v027a09 · Cited by 51 · see citing works

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes

Dunn, S. L., Wilkinson, J. M., Crawford, A., Le Maitre, C. L., & Bunning, R. A. D. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.10.016 · Cited by 46 · see citing works

Osteoarthritis: Role of Peroxisome Proliferator-Activated Receptors

Sheng, W., Wang, Q., Qin, H., Cao, S., Wei, Y., Weng, J., Yu, F., & Zeng, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713137 · Cited by 44 · see citing works

Physiologic and pathologic effects of dietary free fatty acids on cells of the joint

Harasymowicz, N. S., Dicks, A. R., Wu, C., & Guilak, F. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13999 · Cited by 43 · see citing works

Adipokine Signaling Pathways in Osteoarthritis

Zhang, C., Lin, Y., Yan, C. H., & Zhang, W. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.865370 · Cited by 38 · see citing works

Cellular ageing mechanisms in osteoarthritis

Sacitharan, P. K., & Vincent, T. L. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9641-z · Cited by 37 · see citing works

Monounsaturated and Saturated, but Not n-6 Polyunsaturated Fatty Acids Decrease Cartilage Destruction under Inflammatory Conditions

Bastiaansen-Jenniskens, Y. M., Siawash, M., van de Lest, C. H. A., Verhaar, J. A. N., Kloppenburg, M., Zuurmond, A. ‐., Stojanovic-Susulic, V., van Osch, G. J. V. M., & Clockaerts, S. (2013) · Cartilage · doi:10.1177/1947603513494401 · Cited by 37 · see citing works

N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis.

Zhou, P., Xiang, L., Yang, Y.-L., Wu, Y., Hu, T., Liu, X.-L., Lin, F.-T., Xiu, Y., Wu, K., Lu, C.-Z., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104264 · Cited by 32 · see citing works

Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS‐treated mouse chondrocytes and osteoarthritis model

Zhou, Y., Chen, X., Qu, N., Zhang, B., & Xia, C. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14184 · Cited by 31 · see citing works

TGFβ inhibition during expansion phase increases the chondrogenic re-differentiation capacity of human articular chondrocytes

Narcisi, R., Signorile, L., Verhaar, J. A. N., Giannoni, P., & van Osch, G. J. V. M. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.06.010 · Cited by 27 · see citing works

The interrelation of osteoarthritis and diabetes mellitus: considering the potential role of interleukin-10 and in vitro models for further analysis

Schwarz, S., Mrosewski, I., Silawal, S., & Schulze-Tanzil, G. G. (2017) · Inflammation Research · doi:10.1007/s00011-017-1121-8 · Cited by 26 · see citing works

Statins and fibrates do not affect development of spontaneous cartilage damage in STR/Ort mice

Wei, W., Clockaerts, S., Bastiaansen-Jenniskens, Y. M., Gierman, L. M., Botter, S. M., Bierma‐Zeinstra, S., Weinans, H., Verhaar, J. A. N., Kloppenburg, M., Zuurmond, A. ‐., et al. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.11.009 · Cited by 25 · see citing works

Fibrates as therapy for osteoarthritis and rheumatoid arthritis? A systematic review

van Eekeren, I. C. M., Clockaerts, S., Bastiaansen-Jenniskens, Y. M., Lubberts, E., Verhaar, J. A. N., van Osch, G. J. V. M., & Bierma‐Zeinstra, S. (2013) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x12468659 · Cited by 22 · see citing works

PDK4 inhibits osteoarthritis progression by activating the PPAR pathway

Li, Z., Xie, L., Zeng, H., & Wu, Y. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04583-5 · Cited by 20 · see citing works

Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound

Alsalem, M., Haddad, M., Aldossary, S. A., Kalbouneh, H., Altarifi, A., Jaffal, S. M., Abbas, M. A., Aldaoud, N., & El‐Salem, K. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00584-7 · Cited by 20 · see citing works

Cannabinoids: Novel Therapies For Arthritis?

Dunn, S. L., Wilkinson, J. M., Crawford, A., Maitre, C. L. L., & Bunning, R. A. D. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.20 · Cited by 18 · see citing works

Role of peroxisome proliferator-activated receptors in osteoarthritis (Review)

Huang, G., Jiang, W. H., Xie, W., Lü, W., Zhu, W., & Deng, Z. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11798 · Cited by 18 · see citing works

Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague–Dawley rats

Jung, J. I., Lee, H. S., Jeon, Y. E., Kim, S. M., Hong, S. H., Moon, J. M., Lim, C. Y., Kim, Y. H., & Kim, E. J. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00870-3 · Cited by 19 · see citing works

PPARs/macrophages: A bridge between the inflammatory response and lipid metabolism in autoimmune diseases

Wang, Z., Wang, M., Xu, X., Liu, Y., Chen, Q., Wu, B., & Zhang, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149128 · Cited by 17 · see citing works

Sivelestat sodium hydrate improves post-traumatic knee osteoarthritis through nuclear factor-κB in a rat model

Yu, X., Zhao, L., Yu, Z., Yu, C., Bi, J., Binglong, S., & Cong, H. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4684 · Cited by 17 · see citing works

Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β

Duesterdieck‐Zellmer, K. F., Driscoll, N., & Ott, J. F. (2012) · American Journal of Veterinary Research · doi:10.2460/ajvr.73.10.1530 · Cited by 14 · see citing works

Genuine traditional Korean medicine, BaekJeol-Tang for the treatment of rheumatoid arthritis

Han, N., Sim, W.-M., Sul, M.-C., Kim, M., Lee, C., Kim, D., Lee, S.-H., Lee, H.-C., Ryu, J.-M., Nam, B.-S., et al. (2013) · TANG [HUMANITAS MEDICINE] · doi:10.5667/tang.2013.0010 · Cited by 13 · see citing works

PPARD is an Inhibitor of Cartilage Growth in External Ears

Zhang, Z., Duan, Y., Wu, Z., Zhang, H., Ren, J., & Huang, L. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.19714 · Cited by 11 · see citing works

The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis

Li, H., Li, X., Yang, B., Su, J., Cai, S., Huang, J., Hu, T., Chen, L., Xu, Y., & Li, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-96517-y · Cited by 11 · see citing works

Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Costa, M. C., Angelini, C., Franzese, M., Iside, C., Salvatore, M., Laezza, L., Napolitano, F., & Ceccarelli, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05006-z · Cited by 10 · see citing works

Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis

Ipseiz, N., Scholtysek, C., Culemann, S., & Krönke, G. (2014) · Swiss Medical Weekly · doi:10.4414/smw.2014.14055 · Cited by 8 · see citing works

Change in T2* relaxation time of Hoffa fat pad correlates with histologic change in a rat anterior cruciate ligament transection model

Wang, C., Tsai, P., Siow, T. Y., Lee, H., Chang, Y., Hsu, Y., Chiang, S., Lin, M., Chung, H., & Huang, G. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.22914 · Cited by 8 · see citing works

Fenofibrate administration to arthritic rats increases adiponectin and leptin and prevents oxidative muscle wasting

Castillero, E., Martı́n, A. I., Nieto‐Bona, M. P., Fernández‐Galaz, C., López-Menduiña, M., Villanúa, M. Á., & López‐Calderón, A. (2012) · Endocrine Connections · doi:10.1530/ec-12-0003 · Cited by 8 · see citing works

Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

Zhou, Y., Li, L., Chen, X., Zhao, Q., Qu, N., Zhang, B., Jin, X., & Xia, C. (2023) · European journal of medical research · doi:10.1186/s40001-023-01267-4 · Cited by 7 · see citing works

Pleiotropic effects of PPAR-α – from benchside to bedside

Shirinsky, I. V., & Shirinsky, V. S. (2021) · Medical Immunology (Russia) · doi:10.15789/1563-0625-peo-2222 · Cited by 6 · see citing works

Enamel Matrix Derivative has No Effect on the Chondrogenic Differentiation of Mesenchymal Stem Cells

Groeneveldt, L. C., Knuth, C., Witte‐Bouma, J., O’Brien, F. J., Wolvius, E. B., & Farrell, E. (2014) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2014.00029 · Cited by 6 · see citing works

Combined gemfibrozil (peroxisome proliferator-activated receptor alpha agonist) with reduced steroid dose gives a similar management picture as the full steroid dose in a rat adjuvant-induced arthritis model

Ashour, H., Rashed, L. A., Elsebaie, M. M., Sabry, M. M., Abdelmohsen, M. A., & Eissa, M. (2018) · Modern Rheumatology · doi:10.1080/14397595.2018.1508800 · Cited by 3 · see citing works

Subchondral H-type blood vessel formation aggravates articular cartilage degeneration through LEP-LEPR axis

Yu, C., Qin, J., Zhao, X., Luo, S., Zeng, H., Xu, B., & Li, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1751127 · Cited by 2 · see citing works

14.EVALUATION OF THE ANTI-INFLAMMATORY EFFECT OF TELMISARTAN AS AN ADJUVANT THERAPY TO NSAID IN THE MANAGEMENT OF KNEE OSTEOARTHRITIS; A CLINICAL PROSPECTIVE STUDY

Hmood, S., Mohammed, M., Hummadi, Y. M. K. A. M., & Jasim, N. A. (2018) · Iraqi journal of Medical Sciences · doi:10.22578/ijms.16.1.14 · Cited by 2 · see citing works

Osteoarthritis in time for senotherapeutics

Véret, D., Jørgensen, C., & Brondello, J. (2020) · Joint Bone Spine · doi:10.1016/j.jbspin.2020.105084 · Cited by 2 · see citing works

Carnosine-modified gelatin-hyaluronic acid hydrogel comprising fenofibrate-loaded nanoparticles targeting chondrocyte ferroptosis and macrophage polarization for synergistic osteoarthritis therapy

Sheng, W., Guo, T., Yu, B., Zhao, J., Hu, C., Lin, J., Weng, J., Chen, Y., Wang, D., Yu, F., et al. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151281 · Cited by 1 · see citing works

Complementary Regulation of Inflammatory, Catabolic, and PPARγ Signaling by Dexamethasone and Decanoic Acid in Donor-Specific Human Chondrocyte Models

Thomas, G. W., Williams, J. S., Bar-Or, R., Hausburg, M. A., Banton, K. L., & Bar‐Or, D. (2026) · Biomedicines · doi:10.3390/biomedicines14092028 · Cited by 1 · see citing works

The utility of in vitro Precision-Cut Liver Slices to investigate toxicity pathways of contaminants in polar cod (Boreogadus saida)

Aranguren-Abadía, L. (2015) · NORA - Norwegian Open Research Archives · Cited by 1 · see citing works

[Cumulative survival rate of chemotherapy with CDDP for malignant ovarian tumors].

Takada, M., Usui, N., Yoshida, K., Hirayama, H., Suzuki, M., TAKEUCHI, H., Wada, H., Iwasa, T., Yamamoto, T., & Nagasawa, I. (1990) · PubMed · Cited by 1 · see citing works

PPARα activation in portal hypertension

Liu, H., Lee, S. S., Groszmann, R. J., Iwakiri, Y., & Taddei, T. H. (2012) · Hepatology · doi:10.1002/hep.26045

Evaluation of the anti-inflammatory effect of telmisartan as an adjuvant therapy to nsaid in the management of knee osteoarthritis; a clinical prospective study

Mohammed, M. M. (2018) · International Journal of Research in Pharmaceutical Sciences · doi:10.26452/ijrps.v9ispl1.1408

L’arthrose à l’heure des sénothérapies

Véret, D., Jørgensen, C., & Brondello, J. (2021) · Revue du Rhumatisme · doi:10.1016/j.rhum.2021.09.009

Tot jugant a la cara fosca: el treball de les ombres a l'escola bressol

Bonastre, M. J., & Vega, S. (1999) · Dialnet (Universidad de la Rioja)

The Anti-Inflammatory Activity of Palmitoylethanolamide Ameliorates Osteoarthritis Induced by Monosodium Iodoacetate in Sprague Dawley RatsPreprint

Jung, J. I., Lee, H. S., Jeon, Y. E., Kim, S. M., Hong, S. H., Moon, J. M., Lim, C. Y., Kim, Y. H., & Kim, E. J. (2021) · Research Square · doi:10.21203/rs.3.rs-629822/v1 · Cited by 1 · see citing works

Senolytic Development in Osteoarthritis: A New Paradigm

(2021) · Integrative Journal of Orthopaedics and Traumatology · doi:10.31038/ijot.2021422

Additional file 3 of Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Costa, M. C., Angelini, C., Franzese, M., Iside, C., Salvatore, M., Laezza, L., Napolitano, F., & Ceccarelli, M. (2024) · Figshare · doi:10.6084/m9.figshare.26693919

Additional file 6 of Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Costa, M. C., Angelini, C., Franzese, M., Iside, C., Salvatore, M., Laezza, L., Napolitano, F., & Ceccarelli, M. (2024) · Figshare · doi:10.6084/m9.figshare.26693928

Additional file 2 of Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

Zhou, Y., Li, L., Chen, X., Zhao, Q., Qu, N., Zhang, B., Jin, X., & Xia, C. (2024) · Figshare · doi:10.6084/m9.figshare.26616175

Additional file 1 of Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Costa, M. C., Angelini, C., Franzese, M., Iside, C., Salvatore, M., Laezza, L., Napolitano, F., & Ceccarelli, M. (2024) · Figshare · doi:10.6084/m9.figshare.26693913

Additional file 4 of Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Costa, M. C., Angelini, C., Franzese, M., Iside, C., Salvatore, M., Laezza, L., Napolitano, F., & Ceccarelli, M. (2024) · Figshare · doi:10.6084/m9.figshare.26693922

Additional file 1 of PDK4 inhibits osteoarthritis progression by activating the PPAR pathway

Li, Z., Xie, L., Zeng, H., & Wu, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26675933

Additional file 1 of Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

Zhou, Y., Li, L., Chen, X., Zhao, Q., Qu, N., Zhang, B., Jin, X., & Xia, C. (2024) · Figshare · doi:10.6084/m9.figshare.26616172

Additional file 5 of Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Costa, M. C., Angelini, C., Franzese, M., Iside, C., Salvatore, M., Laezza, L., Napolitano, F., & Ceccarelli, M. (2024) · Figshare · doi:10.6084/m9.figshare.26693925

Additional file 2 of Identification of therapeutic targets in osteoarthritis by combining heterogeneous transcriptional datasets, drug-induced expression profiles, and known drug-target interactions

Costa, M. C., Angelini, C., Franzese, M., Iside, C., Salvatore, M., Laezza, L., Napolitano, F., & Ceccarelli, M. (2024) · Figshare · doi:10.6084/m9.figshare.26693916

Additional file 2 of PDK4 inhibits osteoarthritis progression by activating the PPAR pathway

Li, Z., Xie, L., Zeng, H., & Wu, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26675936

Adipose–Joint Crosstalk in Obesity–Induced Osteoarthritis: Mechanisms, Biomarkers, and Translational Therapeutic Opportunities

Hang, W., Triantafilou, K., & Zhou, Y. (2026) · Current Rheumatology Reports · doi:10.1007/s11926-026-01229-9

Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes

Afif, H., Benderdour, M., Endam, L. M., Martel‐Pelletier, J., Pelletier, J., Duval, N., & Fahmi, H. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2151 · Cited by 84 · see citing works

Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs

Hanks, B. C., Kuroki, K., Stoker, A. M., & Cook, J. L. (2010) · American Journal of Veterinary Research · doi:10.2460/ajvr.71.10.1142 · Cited by 6 · see citing works

Chondroprotection of PPARα activation by WY14643 via autophagy involving Akt and ERK in LPS‐treated mouse chondrocytes and osteoarthritis model

Zhou, Y., Chen, X., Qu, N., Zhang, B., & Xia, C. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14184 · Cited by 31 · see citing works

Peroxisome proliferator-activated receptor gamma in osteoarthritis

Fahmi, H., Martel‐Pelletier, J., Pelletier, J., & Kapoor, M. (2010) · Modern Rheumatology · doi:10.1007/s10165-010-0347-x · Cited by 73 · see citing works

Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression in human OA chondrocytes

Nebbaki, S. S., Mansouri, F. E. E., Zayed, N., Benderdour, M., Martel‐Pelletier, J., Pelletier, J., & Fahmi, H. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-s3-p39