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The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice

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Expression of Peroxisome Proliferator-activated Receptors α, β, γ, and H- and L-Prostaglandin D Synthase During Osteoarthritis in the Spontaneous Hartley Guinea Pig and Experimental Dog Models

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Cannabinoids: Novel Therapies For Arthritis?

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The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain

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Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55

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The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update

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Cannabinoids for the treatment of rheumatic diseases — where do we stand?

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A Randomized Controlled Trial of Topical Cannabidiol for the Treatment of Thumb Basal Joint Arthritis

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Cannabinoids and bone regeneration

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Use of Tetrahydrocannabinol and Cannabidiol Products in the Perioperative Period Around Primary Unilateral Total Hip and Knee Arthroplasty

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Antiarthritic Effects of a Root Extract from Harpagophytum procumbens DC: Novel Insights into the Molecular Mechanisms and Possible Bioactive Phytochemicals

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Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial

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Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review

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Harpagophytum procumbens Root Extract Mediates Anti-Inflammatory Effects in Osteoarthritis Synoviocytes through CB2 Activation

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Bones and Joints: The Effects of Cannabinoids on the Skeleton

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Down-Regulation of Cannabinoid Type 1 (CB1) Receptor and its Downstream Signaling Pathways in Metastatic Colorectal Cancer

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Pharmacokinetics, Safety, and Synovial Fluid Concentrations of Single- and Multiple-Dose Oral Administration of 1 and 3 mg/kg Cannabidiol in Horses

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Dose‐Dependent Cannabidiol‐Induced Elevation of Intracellular Calcium and Apoptosis in Human Articular Chondrocytes

Winklmayr, M., Gaisberger, M., Kittl, M., Fuchs, J., Ritter, M., & Jakab, M. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24430 · Cited by 25 · see citing works

The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients

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Monoacylglycerol Lipase Inhibition Using JZL184 Attenuates Paw Inflammation and Functional Deficits in a Mouse Model of Inflammatory Arthritis

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Therapeutic Attributes of Endocannabinoid System against Neuro-Inflammatory Autoimmune Disorders

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Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development

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Enhancing Industrial Hemp (Cannabis sativa) Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications

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Therapeutic Potential for Cannabinoids in Sports Medicine: Current Literature Review

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Components of the Endocannabinoid System and Effects of Cannabinoids Against Bone Diseases: A Mini-Review

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GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms

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Joint problems arising from lack of repair mechanisms: can cannabinoids help?

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Cannabinoids in rheumatology: Friend, foe or a bystander?

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CB1 receptor antagonist rimonabant protects against chronic intermittent hypoxia-induced bone metabolism disorder and destruction in rats

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Cannabis for Rheumatic Disease Pain: a Review of Current Literature

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Cannabinoid receptors are expressed in equine synovium and upregulated with synovitis

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Modulation of Endocannabinoid Tone in Osteoblastic Differentiation of MC3T3-E1 Cells and in Mouse Bone Tissue over Time

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Biased agonism of G protein-coupled receptors as a novel strategy for osteoarthritis therapy

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GPR55 and GPR119 Receptors Contribute to the Processing of Neuropathic Pain in Rats

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Therapeutic Effects of Non-Euphorigenic Cannabis Extracts in Osteoarthritis

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HU308 Mitigates Osteoarthritis by Stimulating Sox9-Related Networks of Carbohydrate Metabolism

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The Impact of JWH-133 on Articular Cartilage Regeneration in Osteoarthritis Via Metalloproteinase 13-Dependent Mechanism

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Cannabinoids in Autoimmune and Rheumatic Diseases

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The GPR55 antagonist CID16020046 mitigates advanced glycation end products (AGEs)- induced chondrocyte activation

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Cannabinoids and Pain for the Plastic Surgeon

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Gene therapies for osteoarthritis: progress and prospects

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Assessment of clinical outcomes in patients with inflammatory arthritis: analysis from the UK Medical Cannabis Registry

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Endocannabinoid Tone and Oxylipins in Rheumatoid Arthritis and Osteoarthritis—A Novel Target for the Treatment of Pain and Inflammation?

Klawitter, J., Clauw, A. D., Seifert, J. A., Klawitter, J., Tompson, B., Sempio, C., Ingram, S., Christians, U., & Moreland, L. W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26125707 · Cited by 5 · see citing works

El Sistema de Endocannabinoides como regulador de la lipogénesis y su posible modulación por la mangiferina

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Histopathological Signatures of the Femoral Head in Patients with Osteonecrosis and Potential Applications in a Multi-Targeted Approach: A Pilot Study

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Monoacylglycerol Lipase and Cyclooxygenase-2 Expression in Osteoarthritic Human Knees

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Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain

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A Fenchone Derivative Effectively Abrogates Joint Damage Following Post-Traumatic Osteoarthritis in Lewis Rats

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Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases

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Influence of the Synthetic Cannabinoid Agonist on Normal and Inflamed Cartilage: An In Vitro Study

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Beyond conventional care: exploring complementary and alternative medicine for autoimmune disorders

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Immunohistochemical assessment of cannabinoid type-1 receptor (CB1R) and its correlation with clinicopathological parameters in glioma

Choucair, N., Saker, Z., Eddine, H. K., Bahmad, H. F., Fares, Y., Zaarour, M., Harati, H., & Nabha, S. M. (2022) · Pathologica · doi:10.32074/1591-951x-294 · Cited by 2 · see citing works

Menopause

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Cannabinoids: new friends in bone fracture and in joint disease prevention?

Palmini, G., Marini, F., Giusti, F., Donati, S., Aurilia, C., Falsetti, I., Zonefrati, R., Galli, G., Iantomasi, T., & Brandi, M. L. (2022) · International Journal of Bone Fragility · doi:10.57582/ijbf.220203.084 · Cited by 1 · see citing works

GPR18 Agonist Resolvin D2 Reduces the Early Brain Injury in A Rat Model of Subarachnoid Hemorrhage by Multi-Mechanisms of ProtectionPreprint

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Имат ли място канабиноидите в лечението на ревматологични и автоимунни заболявания?

Каралилова, Р., Мекенян, Л. Е., Batalov, Z., & Сапунджиева, Т. Л. (2020) · Rheumatology (Bulgaria) · doi:10.35465/28.3.2020.pp84-96

Evaluation of the Expression Levels of Cannabinoid Type-1 (CB1) Receptor and Phosphorylated Extracellular Signal-Regulated Kinase (p-ERK) in GliomasPreprint

Choucair, N., Sakr, Z., Eddine, H. K., Zaarour, M., Harati, H., Fares, Y., Bahmad, H. F., & Nabha, S. M. (2021) · Research Square · doi:10.21203/rs.3.rs-139114/v1

Mecanismo de ação analgésica da dipirona

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Cartilage Repair and Regeneration: Focus on Multi-Disciplinary Strategies

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GPR55 Antagonist CID16020046 Suppresses Collagen-Induced Rheumatoid Arthritis by Suppressing Th1/Th17 Cells in Mice

Lee, J.-E., & Im, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104680

Osteoarthritis

O’Brien, K., & Bosak, C. (2025) · Springer eBooks · doi:10.1007/978-3-032-01737-6_8

Additional file 1 of Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain

Leroux, T. S., Ajrawat, P., Sundararajan, K., Maldonado-Rodriguez, N., Ravi, B., Gandhi, R., Rampersaud, R., Veillette, C., Mahomed, N., & Clarke, H. A. (2024) · Figshare · doi:10.6084/m9.figshare.26742542

Sex-specific hormonal rescue of bone growth in PAPPA2-deficient mice

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PM289, a synthetic CB2 in vitro receptor agonist, modulates morphine-induced antinociceptive effect and withdrawal syndrome in an animal model of osteoarthritic pain

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Expression and function of cannabinoid receptors in normal and osteoarthritic human articular chondrocytes

Andersson, J., Sophocleous, A., Richitor, G., Zhou, Y., Ralston, S. H., & Salter, D. M. (2011) · International Journal of Experimental Pathology

The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.

Dunn, S. L. (2013) · SHURA (Sheffield Hallam University Research Archive) (Sheffield Hallam University)

Cannabinoids: Novel Therapies For Arthritis?

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Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

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