Cited by 1,730Osteoarthritis Treatment and MechanismsMusculoskeletal pain and rehabilitationPain Mechanisms and Treatments

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The epidemiology and impact of pain in osteoarthritis

Open access

Neogi, T.·2013·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2013.03.018PMC PMC3753584

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Abstract

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide, largely due to pain, the primary symptom of the disease. The pain experience in knee OA in particular is well-recognized as typically transitioning from intermittent weight-bearing pain to a more persistent, chronic pain. Methods to validly assess pain in OA studies have been developed to address the complex nature of the pain experience. The etiology of pain in OA is recognized to be multifactorial, with both intra-articular and extra-articular risk factors. Nonetheless, greater insights are needed into pain mechanisms in OA to enable rational mechanism-based management of pain. Consequences of pain related to OA contribute to a substantial socioeconomic burden.

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Authors: Neogi, T.
Affiliations: Boston University (US)
Corresponding author: Neogi, T.
ORCID: Neogi, T.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2013-09
Volume: 21
Issue: 9
Pages: 1145-1153
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2013.03.018
PMC: PMC3753584
OpenAlex: W2113670619
Cited by: 1,730
References: 125
Citations by year: 2026: 118 · 2025: 164 · 2024: 191 · 2023: 185 · 2022: 206 · 2021: 237 · 2020: 226 · 2019: 125 · 2018: 107 · 2017: 71 · 2016: 37 · 2015: 35 · 2014: 22 · 2013: 5
FWCI: 27.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (P60 AR 47785, R01AR062506, K23AR055127, P60AR047785)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: osteoarthritis, knee osteoarthritis, chronic pain, pain mechanisms, pain assessment, socioeconomic burden, disability
MeSH terms: Adult, Aged, Disability Evaluation, Humans, Osteoarthritis, Risk Factors, Socioeconomic Factors, Global Health, Prevalence, Arthralgia, Chronic Pain, Pain Management

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