Cited by 1,730Osteoarthritis Treatment and MechanismsMusculoskeletal pain and rehabilitationPain Mechanisms and Treatments

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The epidemiology and impact of pain in osteoarthritis

Open access

Neogi, T.·2013·Osteoarthritis and Cartilage

DOI 10.1016/j.joca.2013.03.018PMC PMC3753584

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Abstract

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide, largely due to pain, the primary symptom of the disease. The pain experience in knee OA in particular is well-recognized as typically transitioning from intermittent weight-bearing pain to a more persistent, chronic pain. Methods to validly assess pain in OA studies have been developed to address the complex nature of the pain experience. The etiology of pain in OA is recognized to be multifactorial, with both intra-articular and extra-articular risk factors. Nonetheless, greater insights are needed into pain mechanisms in OA to enable rational mechanism-based management of pain. Consequences of pain related to OA contribute to a substantial socioeconomic burden.

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Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888
Projections of Primary and Revision Hip and Knee Arthroplasty in the United States from 2005 to 2030
Kurtz, S. M., Ong, K. L., Lau, E., Mowat, F. S., & Halpern, M. T. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.00222 · Cited by 8,714
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Vos, T., Flaxman, A. D., Naghavi, M., Lozano, R., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., Aboyans, V., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61729-2 · Cited by 8,291
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II
Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H. K., Deyo, R. A., Gabriel, S. E., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,599
Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short‐Form McGill Pain Questionnaire (SF‐MPQ), Chronic Pain Grade Scale (CPGS), Short Form‐36 Bodily Pain Scale (SF‐36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP)
Hawker, G. A., Mian, S., Kendzerska, T., & French, M. (2011) · Arthritis Care & Research · doi:10.1002/acr.20543 · Cited by 4,924
Neuronal plasticity: Increasing the gain in pain
Woolf, C. J., & Salter, M. W. (2000) · Science · doi:10.1126/science.288.5472.1765 · Cited by 3,781
Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
Dworkin, R. H., Turk, D. C., Farrar, J. T., Haythornthwaite, J. A., Jensen, M. P., Katz, N. P., Kerns, R. D., Stucki, G., Allen, R. R., Bellamy, N., et al. (2005) · Pain · doi:10.1016/j.pain.2004.09.012 · Cited by 3,732
Core outcome domains for chronic pain clinical trials: IMMPACT recommendations
Turk, D. C., Dworkin, R. H., Allen, R. R., Bellamy, N., Brandenburg, N., Carr, D. B., Cleeland, C., Dionne, R., Farrar, J. T., Galer, B. S., et al. (2003) · Pain · doi:10.1016/j.pain.2003.08.001 · Cited by 3,510
Classification of chronic pain
Merskey, H. (1994) · Medical Entomology and Zoology · Cited by 2,952
The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis.
Roos, E. M., & Lohmander, S. L. (2003) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-1-64 · Cited by 2,361

Show all 125 references

Research works printed but not linked: 5

Jordan, 2007, Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and caucasians: the Johnston County Osteoarthritis Project, J Rheumatol, 34, 172
Hawker, 2011, Arthritis Care Res (Hoboken), 63, S240
Niu, 2012, Radiographic osteoarthritis severity is associated with an increased risk of developing knee pain: findings from the osteoarthritis initiative, Arthritis Rheum, 64
Messier, 2011, The intenstive diet and exercise for arthritis trial: 18-month clinical outcomes, Arthritis Rheum, 63
White, 2012, Is symptomatic knee osteoarthritis a risk factor for a fast decline in gait speed? Results from the Osteoarthritis Initiative, Arthritis Care Res

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Authors: Neogi, T.
Affiliations: Boston University (US)
Corresponding author: Neogi, T.
ORCID: Neogi, T.
Venue: Osteoarthritis and Cartilage
Publisher: Elsevier BV
Published: 2013-09
Volume: 21
Issue: 9
Pages: 1145-1153
ISSN: 1063-4584 (ISSN-L)
DOI: 10.1016/j.joca.2013.03.018
PMC: PMC3753584
OpenAlex: W2113670619
Cited by: 1,730
References: 125
Citations by year: 2026: 118 · 2025: 164 · 2024: 191 · 2023: 185 · 2022: 206 · 2021: 237 · 2020: 226 · 2019: 125 · 2018: 107 · 2017: 71 · 2016: 37 · 2015: 35 · 2014: 22 · 2013: 5
FWCI: 27.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: Osteoarthritis and Cartilage (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (P60 AR 47785, R01AR062506, K23AR055127, P60AR047785)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords: osteoarthritis, knee osteoarthritis, chronic pain, pain mechanisms, pain assessment, socioeconomic burden, disability
MeSH terms: Adult, Aged, Disability Evaluation, Humans, Osteoarthritis, Risk Factors, Socioeconomic Factors, Global Health, Prevalence, Arthralgia, Chronic Pain, Pain Management

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