Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis
Open accessAbstract
The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to resist repeated load and deformation. The mechanisms by which articular cartilage maintains its integrity throughout our lifetime is not fully understood, however there are numerous regulatory pathways known to govern ECM turnover in response to mechanical stimuli. To further our understanding of this field, we envision that proteomic analysis of the secretome will provide information on how the chondrocyte remodels the surrounding ECM in response to load, in addition to providing information on the metabolic state of the cell. In this review, we attempt to summarize the recent mass spectrometry-based proteomic discoveries in healthy and diseased cartilage and chondrocytes, to facilitate the discovery of novel biomarkers linked to degenerative pathologies, such as osteoarthritis (OA).
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MEPE, TSKU, SEMA3F, SEMA3G and SEMA7A are not expressed in chondrocytes (PJOINT < 2 × 10−6 in all cases).
“Whilst a number of these genes are also expressed in chondrocytes, others such as MEPE, TSKU, SEMA3F, SEMA3G and SEMA7A (PJOINT < 2 × 10−6 in all cases, Fig. 7b) are not65”
From Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease (2021) · cites this paper as [65]
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Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis
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- Authors
- Sanchez, C., Bay-Jensen, A.-C., Pap, T., Dvir-Ginzberg, M., Quasnichka, H., Barrett-Jolley, R., Mobasheri, A., & Henrotin, Y.
- Affiliations
- University of Liège (BE)
- University Hospital Münster (DE)
- University of Surrey (GB)
- King Abdulaziz University (SA)
- Corresponding author
- Sanchez, C.
- Pap, T.
- Quasnichka, H.
- Mobasheri, A.
- Henrotin, Y.
- Venue
- Osteoarthritis and Cartilage
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 25
- Issue
- 8
- Pages
- 1199-1209
- ISSN
- 1063-4584 (ISSN-L)
- OpenAlex
- W2590608480
- Cited by
- 88
- References
- 80
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Osteoarthritis and Cartilage (publishedVersion)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- UWE Research Repository (UWE Bristol) (submittedVersion, cc-by)
- Funders
- European Commission (305815)
- European Commission Framework 7 programme
- European Commission's Innovative Medicines Initiative (IMI)
- Innovative Medicines Initiative (IMI) (115770)
- European Union's Seventh Framework programme (FP7/2007–2013, 305815)
- EFPIA
- Arthritis Research UK (21076)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- osteoarthritis, articular cartilage, extracellular matrix, biomarkers, mechanical loading, cartilage degeneration, chondrocyte metabolism
- MeSH terms
- Cartilage, Articular, Enzymes, Extracellular Matrix, Humans, Osteoarthritis, Proteins, Mass Spectrometry, Biomarkers, Cytokines, Chondrocytes, Proteomics
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