Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays
Open accessAbstract
Objective To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial fluid and to investigate their diagnostic potential in different joint conditions. Methods Two sandwich immunoassays were developed for the quantification of COMP and a COMP neoepitope, using an automated analyser (IDS-iSYS, Immunodiagnostic Systems, Boldon, UK). Assay performance was evaluated in terms of sensitivity, recovery, linearity, and intra- and inter-assay precision. Clinical performance was evaluated by analysing synovial fluid from patients diagnosed with rheumatoid arthritis (RA), reactive arthritis (ReA), osteoarthritis (OA) or acute trauma (AT). Results Both automated assays showed good performance for all parameters tested. Quantification of these biomarkers showed the highest median values for Total COMP in the OA group, followed by the AT group, the ReA group, and the RA group. For the COMP neoepitope the AT group showed the highest median value, followed by the ReA group, the OA group, and the RA group. The ratio COMP neoepitope/Total COMP showed distinct differences between the patients groups, as well as between RA patients with slow or rapid progression of joint damage. Conclusions The newly developed automated assays have a good technical performance, can reliably quantify different epitopes on the COMP molecule and show different levels of the two biomarkers in synovial fluid in patients with different joint diseases. The combination of these two assays, measuring their ratio, shows promise for early detection of patients with RA with different prognosis regarding progression of joint damage.
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CTX-II and COMP are helpful as diagnostic-prognostic biomarkers and are quantifiable by ELISA.
“As diagnostic-prognostic biomarkers and quantifiable by enzyme-linked immunosorbent tests (ELISAs), they are particularly helpful [22].”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [22]
The Introduction (page unavailable) describes COMP as a biomarker for identifying patients at risk of rapid joint destruction, and the Discussion (page unavailable) describes diagnostic and prognostic potential for the COMP assays. The paper does not address CTX-II. Its assay protocols describe automated chemiluminescent immunoassays, not ELISAs, so it does not support the claim about ELISA quantification. (LLM, conf=0.87)
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- Authors
- Lorenzo, P., Aspberg, A., Saxne, T., & Önnerfjord, P.
- Affiliations
- Lund University (SE)
- Corresponding author
- Lorenzo, P.
- Aspberg, A.
- Saxne, T.
- Önnerfjord, P.
- Venue
- Osteoarthritis and Cartilage
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 25
- Issue
- 9
- Pages
- 1436-1442
- ISSN
- 1063-4584 (ISSN-L)
- OpenAlex
- W2610710323
- Cited by
- 28
- References
- 42
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 6 · 2019: 3 · 2018: 4 · 2017: 1
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Osteoarthritis and Cartilage (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Swedish Research Council (2014-3303)
- Lund University Medical Faculty
- Greta & Johan Kock
- Crafoord
- Åke Wiberg
- Alfred Österlund
- Magnus Bergvall
- Reumatikerförbundet
- Gustav V 80-year
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Keywords
- cartilage oligomeric matrix protein, synovial fluid biomarkers, rheumatoid arthritis, reactive arthritis, osteoarthritis, acute trauma, joint damage progression, early diagnosis
- MeSH terms
- Prohibitins, Adolescent, Adult, Aged, Aged, 80 and over, Epitopes, Arthritis, Arthritis, Rheumatoid, Female, Humans, Male, Middle Aged, Osteoarthritis, Prognosis, Sensitivity and Specificity, Synovial Fluid, Biomarkers, Young Adult, Cartilage Oligomeric Matrix Protein
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