CoChat
Sign Up
Cited by 37Craniofacial Disorders and TreatmentsPectus Deformity Diagnosis and TreatmentTraumatic Brain Injury and Neurovascular Disturbances

Intracranial volume measurement of sagittal craniosynostosis

Anderson, Peter J., Netherway, David J., McGlaughlin, Karen, David, David J.·2007·Journal of Clinical Neuroscience
DOI 10.1016/j.jocn.2006.07.001
Open this paper in CoChat — free account

Abstract

We report 41 cases of non-syndromic isolated sagittal synostosis in which evaluation of intracranial volumes was undertaken. Twenty-six were male and fifteen were female. The measured intracranial volumes were then compared with normal age-corrected values. We have found that intracranial volumes were significantly larger than the normal population intracranial volumes in both sexes. However the statistical significance of this finding was much greater in females, (p<0.00002), than males (p<0.040), which was only of borderline significance. The results confirm smaller, earlier studies that intracranial volumes in sagittal synostosis patients are larger than average for age-corrected normal values. Analysis of a sub-set of six patients with sagittal synostosis who were found to have a common polymorphism 294C>T (Asn294Asn) in FGFR3 (fibroblast growth factor Receptor 3) on genetic testing were compared to age and sex matched cases of non-syndromic sagittal synostosis (without an underlying mutation) which confirmed that there were no discernable differences in intracranial volumes between the two groups. We conclude that this investigation supports the role of cranial re-shaping to improve cosmesis as the primary aim of surgical correction in this condition, in the absence of raised intracranial pressure.

Integrity signals

Registry

Crossref · 10.1016/j.jocn.2006.07.001

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Environmental influences, including in utero mechanical constraints, maternal health conditions, medication exposure, and other prenatal risk factors, have been proposed as contributing factors particularly in non-syndromic cases.

    “Environmental influences have also been proposed as contributing factors, particularly in non-syndromic cases. These include in utero mechanical constraints, maternal health conditions, medication exposure, and other prenatal risk factors [1, 2, 11, 22–25].”

    From Genetics versus environment in the pathophysiology of sagittal synostosis (2026) · cites this paper as [23]

  • Synonymous or common variants of FGFR3 have not shown clear pathogenic relevance in sCS.

    “In contrast, synonymous or common variants of FGFR3 have not shown clear pathogenic relevance, emphasizing the need to distinguish true disease-associated findings from background polymorphisms [23, 42].”

    From Genetics versus environment in the pathophysiology of sagittal synostosis (2026) · cites this paper as [23]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Anderson, P. J., Netherway, D. J., McGlaughlin, K., & David, D. J.
Affiliations
Women's and Children's Hospital (AU)
Corresponding author
Anderson, Peter J.
ORCID
Anderson, Peter J.
Venue
Journal of Clinical Neuroscience
Publisher
Elsevier BV
Published
2007-05
Volume
14
Issue
5
Pages
455-458
ISSN
0967-5868 (ISSN-L)
DOI
10.1016/j.jocn.2006.07.001
OpenAlex
W2076479775
Cited by
37
References
15
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 9 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 1
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Clinical Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Pectus Deformity Diagnosis and Treatment
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
sagittal craniosynostosis, intracranial volume, nonsyndromic craniosynostosis, sex differences, intracranial pressure
MeSH terms
Cephalometry, Craniosynostoses, Female, Humans, Infant, Male, Reference Values, Sex Characteristics, Imaging, Three-Dimensional, Receptor, Fibroblast Growth Factor, Type 3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review