Intracranial volume (ICV) in isolated sagittal craniosynostosis measured by 3D photocephalometry: A new perspective on a controversial issue
Abstract
Background There are still controversies regarding the intracranial volumes in patients with isolated sagittal craniosynostosis compared to a healthy population. This study aimed to compare the intracranial volume of children with sagittal synostosis and scaphocephaly to an age- and gender-matched control cohort using three-dimensional (3D) photogrammetry.Methods 62 boys and nine girls with sagittal craniosynostosis were included in this study. The intracranial volume was measured at the first clinical presentation. However, 3D photogrammetry was performed at children not younger than 3 months. The 3D photogrammetric data of 547 healthy boys and 287 healthy girls between the ages of 3-10 month was analyzed to establish an age- and gender-matched control group.Results Male patients with sagittal synostosis showed a significantly reduced intracranial volume compared to the reference group. For female patients, the intracranial volume was slightly lower compared to the norm group, but not significantly.Conclusions Male children with sagittal synostosis showed significantly decreased intracranial volume between the age of 3 and 10 months compared to an age- and gender-matched control group. Female patients in the same age group presented a lower intracranial volume compared to the norm group. Measuring intracranial volume using 3D photogrammetry is a comparable and valuable alternative to CT scans that leads to a significant reduction of radiation exposure to the growing brain.
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Intracranial volume in ISS between the third and tenth months of life is lower than in children of the same age without craniosynostosis.
“Other studies [20] have shown partially different results, namely that the intracranial volume in ISS between the third and tenth months of life is lower than in children of the same age without craniosynostosis [20].”
From Isolated Sagittal Craniosynostosis: A Comprehensive Review (2024) · cites this paper as [20]
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- Authors
- Seeberger, R., Hoffmann, J., Freudlsperger, C., Berger, M., Bodem, J., Horn, D., & Engel, M.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Engel, M.
- Venue
- Journal of Cranio-Maxillofacial Surgery
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 44
- Issue
- 5
- Pages
- 626-631
- ISSN
- 1010-5182 (ISSN-L)
- OpenAlex
- W2281294563
- Cited by
- 25
- References
- 44
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 1 · 2017: 1
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cranio-Maxillofacial Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
- Health Sciences › Medicine › Surgery › Pectus Deformity Diagnosis and Treatment
- Social Sciences › Arts and Humanities › Archeology › Forensic Anthropology and Bioarchaeology Studies
- Keywords
- sagittal craniosynostosis, intracranial volume, scaphocephaly, 3D photogrammetry, sex differences, infants, radiation dose reduction, cranial growth
- MeSH terms
- Cephalometry, Craniosynostoses, Female, Humans, Infant, Male, Photogrammetry, Retrospective Studies, Software, Case-Control Studies, Imaging, Three-Dimensional
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