Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury
Open accessAbstract
Traumatic brain injury (TBI) encompasses a broad range of injury mechanisms and severity. A detailed determination of TBI severity can be a complex challenge, with current clinical tools sometimes insufficient to tailor a clinical response to a spectrum of patient needs. Blood biomarkers of TBI may supplement clinical assessments but currently available biomarkers have limited sensitivity and specificity. While oxidative stress is known to feature in damage mechanisms following TBI, investigation of blood biomarkers of oxidative stress has been limited. This exploratory pilot study of a subset of 18 trauma patients with TBI of varying severity, quantifies circulating concentrations of the structural damage indicators S100b, and myelin basic protein (MBP), and the biomarkers of oxidative stress hydroxynonenal (HNE), malondialdehyde (MDA), carboxy-methyl-lysine (CML), and 8-hydroxy-2'-deoxy-guanosine (8-OHDG). Significant increases in circulating S100b, MBP, and HNE were observed in TBI patient samples compared to 8 uninjured controls, and there was a significant decrease in CML. This small exploratory study supports the current literature on S100b and MBP elevation in TBI, and reveals potential for the use of peripheral oxidative stress markers to assist in determination of TBI severity. Further investigation is required to validate results and confirm trends.
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Immediately following mTBI there is a significant increase of oxidative stress.
“immediately following mTBI there is a significant increase of oxidative stress [52, 140].”
From Early onset senescence and cognitive impairment in a murine model of repeated mTBI (2021) · cites this paper as [52]
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Early onset senescence and cognitive impairment in a murine model of repeated mTBI
Schwab, N., Ju, Y., & Hazrati, L.-N. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01190-x · Cited by 39 · see citing works
- Authors
- Halstrom, A., MacDonald, E., Neil, C., Arendts, G., Fatovich, D., & Fitzgerald, M.
- Affiliations
- The University of Western Australia (AU)
- Harry Perkins Institute of Medical Research (AU)
- Corresponding author
- Halstrom, Alison
- MacDonald, Ellen
- Neil, Claire
- Arendts, Glenn
- Fatovich, Daniel
- Fitzgerald, Melinda
- Venue
- Journal of Clinical Neuroscience
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 35
- Pages
- 104-108
- ISSN
- 0967-5868 (ISSN-L)
- OpenAlex
- W2529384642
- Cited by
- 24
- References
- 24
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 2
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Journal of Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (University of Western Australia) (submittedVersion, cc-by-nc-nd)
- eSpace (Curtin University) (submittedVersion)
- Funders
- National Health and Medical Research Council, Australia
- Topics
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, oxidative stress, blood biomarkers, S100B, myelin basic protein, 4-hydroxynonenal, malondialdehyde, carboxymethyllysine, 8-hydroxy-2'-deoxyguanosine, TBI severity, plasma biomarkers
- MeSH terms
- Brain Injuries, Traumatic, Adult, Aldehydes, Myelin Basic Protein, Female, Humans, Male, Pilot Projects, Prospective Studies, Biomarkers, Treatment Outcome, Oxidative Stress, S100 Calcium Binding Protein beta Subunit
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