Guideline No. 393-Diabetes in Pregnancy
Abstract
Objectives This guideline reviews the evidence relating to the diagnosis and obstetrical management of diabetes in pregnancy. Outcomes The outcomes evaluated were short and long-term maternal outcomes including pre-eclampsia, Caesarean section, future diabetes and other cardiovascular complications; and fetal outcomes including congenital anomalies, stillbirth, macrosomia, birth trauma, hypoglycemia and long-term effects. Evidence Published literature was retrieved through searches of PubMed and The Cochrane Library using appropriate controlled vocabulary (MeSH terms "diabetes" and "pregnancy"). Where appropriate, results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. There were no date limits but results were limited to English or French language materials. Values The quality of evidence was rated using the criteria described in the Report of the Canadian Task Force on Preventive Health Care. Summary statements RECOMMENDATIONS.
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In Canada, the incidence of gestational diabetes mellitus changed from 3.8 to 6.5% (SOGC) or 2.0-4.0% (DA) in 1992 to 7.0% using the two-step method or 16.1% using the one-step method.
“Analyzing the data, the incidence of GDM changed from 3.8 to 6.5% (SOGC) or 2.0–4.0% (DA) in 1992 to 7.0% using the two-step method or to 16.1% using the one-step method.”
From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [67]
Cites
Hyperglycemia and adverse pregnancy outcomes
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Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes
Crowther, C. A., Hiller, J. E., Moss, J. R., McPhee, A. J., Jeffries, W. S., & Robinson, J. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042973 · Cited by 3,159 · see citing works
Buchanan, T. A., & Xiang, A. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524531 · Cited by 2,123 · see citing works
A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes
Landon, M. B., Spong, C. Y., Thom, E., Carpenter, M. W., Ramin, S. M., Casey, B., Wapner, R. J., Varner, M. W., Rouse, D. J., Thorp, J. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0902430 · Cited by 2,122 · see citing works
Metzger, B. E., Gabbe, S. G., Persson, B., Lowe, L. P., Dyer, A. R., Oats, J. J. N., & Buchanan, T. A. (2010) · Diabetes Care · doi:10.2337/dc10-0719 · Cited by 1,888 · see citing works
Antenatal Betamethasone for Women at Risk for Late Preterm Delivery
Gyamfi-Bannerman, C., Thom, E. A., Blackwell, S. C., Tita, A. T. N., Reddy, U. M., Saade, G. R., Rouse, D. J., McKenna, D. S., Clark, E. A. S., Thorp, J. M., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1516783 · Cited by 814 · see citing works
Manifestations of chronic disease during pregnancy
Kaaja, R. J. (2005) · JAMA · doi:10.1001/jama.294.21.2751 · Cited by 382 · see citing works
Feig, D. S., Berger, H., Donovan, L., Godbout, A., Kader, T., Keely, E., & Sanghera, R. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.038 · Cited by 344 · see citing works
Self-citationRates of postpartum glucose testing after gestational diabetes mellitus
Russell, M. A., Phipps, M. G., Olson, C. L., Welch, H. G., & Carpenter, M. W. (2006) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000245446.85868.73 · Cited by 165 · see citing works
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Evolution of Gestational Diabetes Mellitus across Continents in 21st Century
Dłuski, D. F., Ruszała, M., Rudziński, G., Pożarowska, K., Brzuszkiewicz, K., & Leszczyńska-Gorzelak, B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192315804 · Cited by 41 · see citing works
Placental metabolomics for assessment of pregnancy complications: A systematic review
Mercer, G. V., & Cahill, L. S. (2026) · Molecular Omics · doi:10.1093/molecular-omics/aaiag015 · Cited by 2 · see citing works
- Authors
- Berger, H., Gagnon, R., & Sermer, M.
- Corresponding author
- Berger, Howard
- Venue
- Journal of Obstetrics and Gynaecology Canada
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 41
- Issue
- 12
- Pages
- 1814-1825.e1
- ISSN
- 1701-2163 (ISSN-L)
- OpenAlex
- W2990526949
- Cited by
- 106
- References
- 10
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 25 · 2023: 13 · 2022: 23 · 2021: 16 · 2020: 6
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Update notices
- erratum (2020-10-01)
- Open access
- closed
- Locations
- Journal of Obstetrics and Gynaecology Canada (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- diabetes in pregnancy, gestational diabetes mellitus, pre-existing diabetes mellitus, preconception care, glycemic control, stillbirth, preeclampsia, cesarean section, shoulder dystocia, macrosomia, type 2 diabetes risk, glucose challenge test, 75 g oral glucose tolerance test, fetal monitoring, multidisciplinary management, congenital malformations
- MeSH terms
- Female, Humans, Mass Screening, Pregnancy, Pregnancy in Diabetics, Preventive Health Services, Diabetes, Gestational, Stillbirth, Perinatal Mortality
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