Placental metabolomics for assessment of pregnancy complications: A systematic review
Open accessAbstract
Metabolomics is a powerful tool for understanding biological function at the cellular level. While this omics technology has found application in areas ranging from toxicology to cancer, its potential for the study of human pregnancy complications is in its infancy. Proper placental function is critical for a healthy pregnancy and assessing placental metabolism offers a direct window into placental physiology. This review aims to analyse placental metabolomics in pregnancy complications in humans. A systematic search was completed using PubMed and Google Scholar, and the Covidence software was used for the screening process. Following title and abstract screening and full-text review, 32 articles remained and were included in this review. Multiple articles performed metabolomics using mass spectrometry and/or nuclear magnetic resonance to study pre-eclampsia, gestational hypertension, foetal growth restriction, maternal obesity, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and preterm birth. A subset of pregnancy complications was investigated in only a single study each (human immunodeficiency virus in pregnancy, neural tube defects, chromosomal disorders, chronic hypoxia, and recurrent pregnancy loss). Univariate analyses identified potential biomarkers of pregnancy complications. Multivariate analyses demonstrated that the placental global metabolic profiles could separate healthy and complicated pregnancies and identified metabolic pathways (e.g. amino acid metabolism, lipid and phospholipid metabolism) to explain pathogenesis and the mechanisms of disease. We highlight knowledge gaps and future directions, emphasizing the need for data replication and inclusion of variables such as biological sex in the field of placental metabolomics.
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A systematic review of 32 human placental metabolomics studies identified recurring perturbations in amino-acid, lipid and energy-related pathways across pregnancy complications, but outcomes were confined largely to pregnancy and birth.
“A systematic review of 32 human placental metabolomics studies identified recurring perturbations in amino-acid, lipid and energy-related pathways across pregnancy complications, but the outcomes were confined largely to pregnancy and birth [136].”
From Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures (2026) · cites this paper as [136]
The Abstract reports a systematic review of 32 human placental metabolomics articles and identifies amino-acid and lipid/phospholipid metabolism among the pathways associated with pregnancy complications. It does not identify recurring energy-related pathways or establish that the studies’ outcomes were confined largely to pregnancy and birth. (LLM, conf=0.86)
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Self-citation
Flagged first, then by citations
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Cited by
Sorted by citations
Panteris, E., Kakatsaki, I., Koukou, Z., Kolvatzis, C., Papanikolaou, S., & Hatzidaki, E. (2026) · Pathophysiology · doi:10.3390/pathophysiology33030067
Eke, A. C., Eleje, G. U., Sani, M. U., Ezebialu, I. U., Dankishiya, F. S., Sodangi, I. S., Ibrahim, I. Y., Wester, C. W., Aliyu, M. H., & Graham, D. R. (2026) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2026.2741065
- Authors
- Mercer, G. V., & Cahill, L. S.
- Affiliations
- Memorial University of Newfoundland (CA)
- Corresponding author
- Cahill, Lindsay S
- ORCID
- Cahill, Lindsay S
- Venue
- Molecular Omics
- Publisher
- Oxford University Press (OUP)
- Published
- 2026-04-11
- Volume
- 22
- Issue
- 3
- ISSN
- 2515-4184 (ISSN-L)
- OpenAlex
- W7154092144
- Cited by
- 2
- References
- 118
- Citations by year
- 2026: 2
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- Locations
- Molecular Omics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Suncor Energy and Memorial University
- Terra Nova Innovator Award
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- placental metabolomics, pregnancy complications, preeclampsia, gestational hypertension, fetal growth restriction, maternal obesity, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, preterm birth, biomarkers, amino acid metabolism, placental metabolism, sex differences
- MeSH terms
- Female, Humans, Placenta, Pregnancy, Pregnancy Complications, Biomarkers, Metabolomics, Metabolome
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