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Cited by 117Reproductive Health and ContraceptionBone health and osteoporosis researchHypothalamic control of reproductive hormones

Bone mineral density in adolescent females using depot medroxyprogesterone acetate

Lara-Torre, Eduardo, Edwards, Catherine P, Perlman, Sally, Hertweck, S.Paige·2004·Journal of Pediatric and Adolescent Gynecology
DOI 10.1016/j.jpag.2003.11.017
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Abstract

Study objective To examine bone mineral density (BMD) on a semi-annual basis among control subjects and adolescent females receiving depot medroxyprogesterone acetate (DMPA) injection or oral contraceptives.Design Non-randomized prospective study.Setting Teenage pregnancy prevention intervention clinic.Participants Adolescent females who were new users of DMPA injection (N=58, age 12-21) or the oral contraceptive pill (N=71, age 11-19) and normal menstruating girls (N=19, age 15-18).Interventions Baseline and 6-monthly measures of lumbar vertebral BMD using dual-energy X-ray absorptiometry over a 2-year period.Main outcome measures comparison of percent change on BMD over time between DMPA users, pill users, and normal menstruating girls.Results There was no difference on group characteristics at baseline except for the ethnicity between the controls and the DMPA group. There was a statistically significant decrease in BMD between DMPA users and controls at 6 months (-3.02% change, P=0.014) 12 months (-3.38% change, P=0.001) 18 months (-4.81% change, P<0.001) and 24 months (-6.81% change, P=0.010). There was no statistical difference between pill users and controls.Conclusion There is a relationship between DMPA use and a decrease in BMD compared to normal menstruating controls that seems to persist up to 24 months.

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Crossref · 10.1016/j.jpag.2003.11.017

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  • Prolonged DMPA use is associated with decrease in BMD and increased risk of fracture due to estrogen deficiency.

    “One of major sources of concerns regarding prolonged use of DMPA is the decrease of BMD and the increase risk of fracture, due to estrogen deficiency accompanying its use.”

    From Oral and depot progestin therapy for endometriosis: towards a personalized medicine (2017) · cites this paper as [60]

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Authors
Lara-Torre, E., Edwards, C. P., Perlman, S., & Hertweck, S. P.
Affiliations
University of Louisville (US)
Venue
Journal of Pediatric and Adolescent Gynecology
Publisher
Elsevier BV
Published
2004-02
Volume
17
Issue
1
Pages
17-21
ISSN
  • 0932-8610 (ISSN-L)
  • 1083-3188
DOI
10.1016/j.jpag.2003.11.017
OpenAlex
W1970320888
Cited by
117
References
20
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 1 · 2012: 5
FWCI
12.56
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Pediatric and Adolescent Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
bone mineral density, depot medroxyprogesterone acetate, oral contraceptives, adolescent girls, bone loss, lumbar spine, contraceptive side effects, adolescent pregnancy prevention
MeSH terms
Administration, Oral, Adolescent, Adult, Child, Contraceptive Agents, Female, Female, Humans, Injections, Prospective Studies, Absorptiometry, Photon, Bone Density, Medroxyprogesterone Acetate

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