The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Potential Genetic Risk Factors for Chronic TMD: Genetic Associations from the OPPERA Case Control Study
Open accessAbstract
Genetic factors play a role in the etiology of persistent pain conditions, putatively by modulating underlying processes such as nociceptive sensitivity, psychological well-being, inflammation, and autonomic response. However, to date, only a few genes have been associated with temporomandibular disorders (TMD). This study evaluated 358 genes involved in pain processes, comparing allelic frequencies between 166 cases with chronic TMD and 1442 controls enrolled in the OPPERA (Orofacial Pain: Prospective Evaluation and Risk Assessment) study cooperative agreement. To enhance statistical power, 182 TMD cases and 170 controls from a similar study were included in the analysis. Genotyping was performed using the Pain Research Panel, an Affymetrix gene chip representing 3295 single nucleotide polymorphisms, including ancestry-informative markers that were used to adjust for population stratification. Adjusted associations between genetic markers and TMD case status were evaluated using logistic regression. The OPPERA findings provided evidence supporting previously-reported associations between TMD and two genes: HTR2A and COMT. Other genes were revealed as potential new genetic risk factors for TMD, including NR3C1, CAMK4, CHRM2, IFRD1, and GRK5. While these findings need to be replicated in independent cohorts, the genes potentially represent important markers of risk for TMD and they identify potential targets for therapeutic intervention.
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Cites
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · cited 2×
“95 (n=38); (2) duplicate genotypes (n=20); (3) cryptic relatedness (n=84); (4) mismatch between genotypic and self-reported sex and race (n=29); and (5) case misclassification (n=14).”
BackgroundAdjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix
Li, J., & Ji, L. (2005) · Heredity · doi:10.1038/sj.hdy.6800717 · Cited by 1,458
Cited by
Current Understanding of Pathogenesis and Treatment of TMJ Osteoarthritis
Wang, X. D., Zhang, J. N., Gan, Y. H., & Zhou, Y. H. (2015) · Journal of Dental Research · doi:10.1177/0022034515574770 · Cited by 538
The phenotypic and genetic signatures of common musculoskeletal pain conditions
Diatchenko, L., Fillingim, R. B., Smith, S. B., & Maixner, W. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.43 · Cited by 241
Self-citationCentral sensitization in humans: assessment and pharmacology
Arendt-Nielsen, L. (2015) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-662-46450-2_5 · Cited by 125
Huijnen, I. P. J., Rusu, A. C., Scholich, S., Meloto, C. B., & Diatchenko, L. (2015) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000100 · Cited by 44
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Metadata
- Authors
- Smith, S. B., Maixner, D. W., Greenspan, J. D., Dubner, R., Fillingim, R. B., Ohrbach, R., Knott, C., Slade, G. D., Bair, E., Gibson, D. G., Zaykin, D. V., Weir, B. S., Maixner, W., & Diatchenko, L.
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 12
- Issue
- 11
- Pages
- T92-T101
- ISSN
- 1526-5900 (ISSN-L)
- OpenAlex
- W2023007719
- Cited by
- 212
- References
- 2
- FWCI
- 24.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Smith, S. B., Maixner, D. W., Greenspan, J. D., Dubner, R., Fillingim, R. B., Ohrbach, R., Knott, C., Slade, G. D., Bair, E., Gibson, D. G., Zaykin, D. V., Weir, B. S., Maixner, W., & Diatchenko, L. (2011). Potential Genetic Risk Factors for Chronic TMD: Genetic Associations from the OPPERA Case Control Study. The Journal of Pain. https://doi.org/10.1016/j.jpain.2011.08.005
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