Central sensitization in humans: assessment and pharmacology

Cellular and Molecular Mechanisms of Pain

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Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values

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Quantitative sensory testing: a comprehensive protocol for clinical trials

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Pathological and protective roles of glia in chronic pain

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Models and Mechanisms of Hyperalgesia and Allodynia

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Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

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An association between migraine and cutaneous allodynia

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Chronic pain and medullary descending facilitation

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Sensitization in patients with painful knee osteoarthritis

Arendt‐Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., & Graven‐Nielsen, T. (2010) · Pain · doi:10.1016/j.pain.2010.04.003 · Cited by 992 · see citing works

Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee.

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Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data

Magerl, W., Krumova, E. K., Baron, R., Tölle, T. R., Treede, R., & Maier, C. (2010) · Pain · doi:10.1016/j.pain.2010.07.026 · Cited by 604 · see citing works

Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy

Yarnitsky, D., Granot, M., Nahman‐Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012) · Pain · doi:10.1016/j.pain.2012.02.021 · Cited by 561 · see citing works

Experimental and Clinical Applications of Quantitative Sensory Testing Applied to Skin, Muscles and Viscera

Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548 · see citing works

Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects

Kosek, E., & Hansson, P. T. (1997) · Pain · doi:10.1016/s0304-3959(96)03295-2 · Cited by 539 · see citing works

Recommendations on terminology and practice of psychophysical DNIC testing

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Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery

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Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo

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Bad news from the brain: descending 5-HT pathways that control spinal pain processing

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Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief

Kosek, E., & Ordeberg, G. (2000) · Pain · doi:10.1016/s0304-3959(00)00310-9 · Cited by 476 · see citing works

Translation of symptoms and signs into mechanisms in neuropathic pain

Jensen, T. S., & Baron, R. (2003) · Pain · doi:10.1016/s0304-3959(03)00006-x · Cited by 468 · see citing works

Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia

Banič, B., Petersen‐Felix, S., Andersen, O. K., Radanov, B. P., Villiger, M. P., Arendt‐Nielsen, L., & Curatolo, M. (2003) · Pain · doi:10.1016/j.pain.2003.05.001 · Cited by 462 · see citing works

Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies

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Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients

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Thalamic sensitization transforms localized pain into widespread allodynia

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Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome

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The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input

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Normalization of widespread hyperesthesia and facilitated spatial summation of deep‐tissue pain in knee osteoarthritis patients after knee replacement

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Test–retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): A multi-centre study

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Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study

Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Pain · doi:10.1016/s0304-3959(01)00300-1 · Cited by 317 · see citing works

Generalised muscular hyperalgesia in chronic whiplash syndrome

Johansen, M. K., Graven‐Nielsen, T., Olesen, A. S., & Arendt‐Nielsen, L. (1999) · Pain · doi:10.1016/s0304-3959(99)00106-2 · Cited by 307 · see citing works

Electrophysiological and psychophysical quantification of temporal summation in the human nociceptive system

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The reflex sympathetic dystrophy syndrome

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Generalized deep‐tissue hyperalgesia in patients with chronic low‐back pain

O’Neill, S. F. D., Manniche, C., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2006.05.009 · Cited by 300 · see citing works

Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions

Staud, R. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.41 · Cited by 290 · see citing works

The Reflex Sympathetic Dystrophy Syndrome

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Hyperexcitability in fibromyalgia.

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Widespread Sensory Hypersensitivity Is a Feature of Chronic Whiplash-Associated Disorder but not Chronic Idiopathic Neck Pain

Scott, D. S., Jull, G. A., & Sterling, M. M. (2005) · Clinical Journal of Pain · doi:10.1097/00002508-200503000-00009 · Cited by 281 · see citing works

Abnormal Modulatory Influence of Diffuse Noxious Inhibitory Controls in Migraine and Chronic Tension-Type Headache Patients

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Lamotrigine in spinal cord injury pain: a randomized controlled trial

Finnerup, N. B., Sindrup, S. H., Bach, F. W., Johannesen, I. L., & Jensen, T. S. (2002) · Pain · doi:10.1016/s0304-3959(01)00484-5 · Cited by 275 · see citing works

Endometriosis is associated with central sensitization: a psychophysical controlled study

Bajaj, P. (2003) · The Journal of Pain · doi:10.1016/s1526-5900(03)00720-x · Cited by 247 · see citing works

Potential Genetic Risk Factors for Chronic TMD: Genetic Associations from the OPPERA Case Control Study

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Extraterritorial neuropathic pain correlates with multisegmental elevation of spinal dynorphin in nerve-injured rats

Malan, P. T., Ossipov, M. H., Gardell, L. R., Ibrahim, M. M., Bian, D., Lai, J. Y., & Porreca, F. (2000) · Pain · doi:10.1016/s0304-3959(00)00243-8 · Cited by 200 · see citing works

Group differences in pain modulation: pain-free women compared to pain-free men and to women with TMD

Bragdon, E. E., Light, K. C., Costello, N. L., Sigurðsson, Á., Bunting, S., Bhalang, K., & Maixner, W. D. (2002) · Pain · doi:10.1016/s0304-3959(01)00451-1 · Cited by 196 · see citing works

Reference values of mechanical and thermal pain tests in a pain‐free population

Neziri, A. Y., Scaramozzino, P., Andersen, O. K., Dickensonl, A. H., Arendt‐Nielsen, L., & Curatolol, M. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.08.011 · Cited by 194 · see citing works

Health related quality of life and quantitative pain measurement in females with chronic non‐malignant pain

Laursen, B. S., Bajaj, P., Olesen, A. S., Delmar, C., & Arendt‐Nielsen, L. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.07.003 · Cited by 191 · see citing works

Bilateral Widespread Mechanical Pain Sensitivity in Women With Myofascial Temporomandibular Disorder: Evidence of Impairment in Central Nociceptive Processing

Fernández‐de‐las‐Peñas, C., Galán-del-Río, F., Fernández‐Carnero, J., Pesquera, J., Arendt‐Nielsen, L., & Svensson, P. J. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.04.017 · Cited by 187 · see citing works

Correlates of knee pain among US adults with and without radiographic knee osteoarthritis.

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Viscero-visceral hyperalgesia: Characterization in different clinical models

Giamberardino, M. A., Costantini, R., Affaitati, G., Fabrizio, A., Lapenna, D., Tafuri, E., & Mezzetti, A. (2010) · Pain · doi:10.1016/j.pain.2010.06.023 · Cited by 184 · see citing works

SITE OF PAIN FROM THE IRRITABLE BOWEL

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Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Unilateral Epicondylalgia

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Transient Analgesia Evoked by Noxious Stimulus Offset

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Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain

John, M. T., Miglioretti, D. L., LeResche, L., Korff, M. V., & Critchlow, C. W. (2003) · Pain · doi:10.1016/s0304-3959(02)00404-9 · Cited by 167 · see citing works

Reactivity to superficial and deep stimuli in patients with chronic musculoskeletal pain

Carli, G., Suman, A. L., Biasi, G., & Marcolongo, R. (2002) · Pain · doi:10.1016/s0304-3959(02)00297-x · Cited by 162 · see citing works

Memantine (a N-Methyl-d-Aspartate Receptor Antagonist) in the Treatment of Neuropathic Pain After Amputation or Surgery: A Randomized, Double-Blinded, Cross-Over Study

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Peripheral pain mechanisms in chronic widespread pain

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The NMDA receptor antagonist amantadine reduces surgical neuropathic pain in cancer patients: a double blind, randomized, placebo controlled trial

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Spreading of complex regional pain syndrome: not a random process

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Capsaicin evoked pain and allodynia in post-herpetic neuralgia

Petersen, K. L., Fields, H. L., Brennum, J., Sandroni, P., & Rowbotham, M. C. (2000) · Pain · doi:10.1016/s0304-3959(00)00311-0 · Cited by 152 · see citing works

Widespread sensitization in patients with chronic pain after revision total knee arthroplasty

Skou, S. T., Graven‐Nielsen, T., Rasmussen, S., Simonsen, O. H., Laursen, M. B., & Arendt‐Nielsen, L. (2013) · Pain · doi:10.1016/j.pain.2013.04.033 · Cited by 150 · see citing works

Chronic widespread pain in the spectrum of rheumatological diseases

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Multi-dimensionality of chronic pain of the oral cavity and face

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Modulation of Central Hypersensitivity by Nociceptive Input in Chronic Pain After Whiplash Injury

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Sustained Nociceptive Mechanical Stimulation of Latent Myofascial Trigger Point Induces Central Sensitization in Healthy Subjects

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A survey of spinal dorsal horn neurones encoding the spatial organization of withdrawal reflexes in the rat

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Muscle Pain: Sensory Implications and Interaction With Motor Control

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Multiple reflex sympathetic dystrophy. Which patients are at risk for developing a recurrence of reflex sympathetic dystrophy in the same or another limb

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Widespread hypersensitivity is related to altered pain inhibition processes in irritable bowel syndrome

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Immune responses of microglia in the spinal cord: Contribution to pain states

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Induction and assessment of experimental pain from human skin, muscle, and viscera

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Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgia

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Chronic back pain, acute postoperative pain and the activation of diffuse noxious inhibitory controls (DNIC)

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Offset Analgesia in Neuropathic Pain Patients and Effect of Treatment with Morphine and Ketamine

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Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis

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The NMDA (N‐methyl‐D‐aspartate) receptor antagonist memantine in the treatment of postherpetic neuralgia: A double‐blind, placebo‐controlled study

Eisenberg, E., Kleiser, A., Dortort, A., Haim, T., & Yarnitsky, D. (1998) · European Journal of Pain · doi:10.1016/s1090-3801(98)90030-1 · Cited by 102 · see citing works

Prevalence of temporomandibular disorders in fibromyalgia and failed back syndrome patients: A blinded prospective comparison study

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Offset analgesia: A temporal contrast mechanism for nociceptive information

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Spatial and temporal summation of pain evoked by mechanical pressure stimulation

Nie, H., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2008.07.013 · Cited by 97 · see citing works

Systemic Inflammation Decreases Pain Threshold in Humans In Vivo

de Goeij, M., van Eijk, L. T., Vanelderen, P., Wilder‐Smith, O. H. G., Vissers, K. C. P., van der Hoeven, J. G., Kox, M., Scheffer, G. J., & Pickkers, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084159 · Cited by 96 · see citing works

Spatial summation of heat induced pain within and between dermatomes

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Spatial and temporal aspects of deep tissue pain assessed by cuff algometry

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Effect of ketamine on endogenous pain modulation in healthy volunteers

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Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans

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Widespread pain following whiplash-associated disorders: incidence, course, and risk factors.

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Dorsal horn convergent neurones: negative feedback triggered by spatial summation of nociceptive afferents

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Spatial summation of mechanically evoked muscle pain and painful aftersensations in normal subjects and fibromyalgia patients

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Bilateral Sensory Abnormalities in Patients with Unilateral Neuropathic Pain; A Quantitative Sensory Testing (QST) Study

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Trigger Points in Patients with Lower Limb Osteoarthritis

Bajaj, P., Bajaj, P., Graven‐Nielsen, T., & Arendt‐Nielsen, L. (2001) · Journal of Musculoskeletal Pain · doi:10.1300/j094v09n03_03 · Cited by 80 · see citing works

Assessment of Pressure-Pain Thresholds and Central Sensitization of Pain in Lateral Epicondylalgia

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Generalized expansion of nociceptive reflex receptive fields in chronic pain patients

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Offset analgesia is reduced in older adults

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