The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data
Open accessAbstract
UNLABELLED Chronic neuropathic pain, the most frequent condition affecting the peripheral nervous system, remains underdiagnosed and difficult to treat. Inhaled cannabis may alleviate chronic neuropathic pain. Our objective was to synthesize the evidence on the use of inhaled cannabis for chronic neuropathic pain. We performed a systematic review and a meta-analysis of individual patient data. We registered our protocol with PROSPERO CRD42011001182. We searched in Cochrane Central, PubMed, EMBASE, and AMED. We considered all randomized controlled trials investigating chronic painful neuropathy and comparing inhaled cannabis with placebo. We pooled treatment effects following a hierarchical random-effects Bayesian responder model for the population-averaged subject-specific effect. Our evidence synthesis of individual patient data from 178 participants with 405 observed responses in 5 randomized controlled trials following patients for days to weeks provides evidence that inhaled cannabis results in short-term reductions in chronic neuropathic pain for 1 in every 5 to 6 patients treated (number needed to treat = 5.6 with a Bayesian 95% credible interval ranging between 3.4 and 14). Our inferences were insensitive to model assumptions, priors, and parameter choices. We caution that the small number of studies and participants, the short follow-up, shortcomings in allocation concealment, and considerable attrition limit the conclusions that can be drawn from the review. The Bayes factor is 332, corresponding to a posterior probability of effect of 99.7%. PERSPECTIVE This novel Bayesian meta-analysis of individual patient data from 5 randomized trials suggests that inhaled cannabis may provide short-term relief for 1 in 5 to 6 patients with neuropathic pain. Pragmatic trials are needed to evaluate the long-term benefits and risks of this treatment.
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Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
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Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
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GRADE guidelines: 3. Rating the quality of evidence
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Pharmacologic management of neuropathic pain: Evidence-based recommendations
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Bayesian estimation supersedes the t-test
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Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial
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Cited by
Stockings, E., Campbell, G., Hall, W. D., Nielsen, S., Zagic, D., Rahman, R., Murnion, B., Farrell, M., Weier, M., & Degenhardt, L. (2018) · Pain · doi:10.1097/j.pain.0000000000001293 · Cited by 460
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Self-citationHäuser, W., Petzke, F., & Fitzcharles, M. A. (2018) · European Journal of Pain · doi:10.1002/ejp.1118 · Cited by 175
Petzke, F., Enax-Krumova, E. K., & Häuser, W. (2016) · Der Schmerz · doi:10.1007/s00482-015-0089-y · Cited by 80
Bell, A. D., MacCallum, C., Margolese, S., Walsh, Z., Wright, P., Daeninck, P. J., Mandarino, E., Lacasse, G., Kaur Deol, J., de Freitas, L., et al. (2024) · Cannabis & Cannabinoid Research · doi:10.1089/can.2021.0156 · Cited by 78
Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation
van den Hoogen, N. J., Harding, E. K., Davidson, C. E. D., & Trang, T. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.816747 · Cited by 45
Psychotic disorder and cannabis use: Canadian hospitalization trends, 2006–2015
Maloney-Hall, B., Wallingford, S. C., Konefal, S., & Young, M. M. (2020) · Health Promotion and Chronic Disease Prevention in Canada · doi:10.24095/hpcdp.40.5/6.06 · Cited by 21
Metadata
- Authors
- Andreae, M. H., Carter, G. M., Shaparin, N., Suslov, K., Ellis, R. J., Ware, M. A., Abrams, D. I., Prasad, H., Wilsey, B., Indyk, D., Johnson, M., & Sacks, H. S.
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 16
- Issue
- 12
- Pages
- 1221-1232
- ISSN
- 1526-5900 (ISSN-L)
- OpenAlex
- W1409549508
- Cited by
- 266
- References
- 20
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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