Cannabis use in HIV for pain and other medical symptoms
Open accessAbstract
Despite the major benefits of antiretroviral therapy on survival during HIV infection, there is an increasing need to manage symptoms and side effects during long-term drug therapy. Cannabis has been reported anecdotally as being beneficial for a number of common symptoms and complications in HIV infections, for example, poor appetite and neuropathy. This study aimed to investigate symptom management with cannabis. Following Ethics Committee approval, HIV-positive individuals attending a large clinic were recruited into an anonymous cross-sectional questionnaire study. Up to one-third (27%, 143/523) reported using cannabis for treating symptoms. Patients reported improved appetite (97%), muscle pain (94%), nausea (93%), anxiety (93%), nerve pain (90%), depression (86%), and paresthesia (85%). Many cannabis users (47%) reported associated memory deterioration. Symptom control using cannabis is widespread in HIV outpatients. A large number of patients reported that cannabis improved symptom control.
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In the five studies on nausea in chronic pain, each involved whole plant cannabis in inhaled or oral formats, and patients reported moderate relief.
“Each study involved whole plant cannabis in inhaled or oral formats, with patients reporting moderate relief.”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [88]
The Patient Choice of Route and Timing for Symptom Control section reports that HIV patients smoked cannabis or ingested the plant, and Effect on Symptoms reports improvement in nausea. But this paper reports one HIV patient study, not five studies of nausea in chronic pain, and it does not characterize the relief across five studies as moderate. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThree cross-sectional studies also report antidepressant effects of CBM.
“Three cross-sectional studies also report antidepressant effects of CBM.82,97,98”
From Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions (2024) · cites this paper as [97]
Among symptoms improved following cannabis were appetite (97% reported improvement), pain (improved in 94% of patients with pain), nausea (93% reported improvement), and anxiety (93% reported improvement).
“Among the symptoms improved following cannabis were appetite (97% reported improvement), pain (improved in 94% of the patients with pain), nausea (93% reported improvement) and anxiety (93% reported improvement).138”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [138]
An anonymous cross-sectional questionnaire study revealed that as many as one-third of patients suffering from HIV have used cannabis to treat symptoms.
“An anonymous cross-sectional questionnaire study revealed that as many as one-third of patients suffering from HIV have used cannabis to treat symptoms.138”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [138]
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Cites
Changing patterns of mortality across Europe in patients infected with HIV-1
Mocroft, A., Vella, S., Benfield, T., Chiesi, A., Miller, V., Gargalianos, P., Monforte, A. D., Yust, I., Bruun, J., Phillips, A. N., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03201-2 · Cited by 1,269 · see citing works
Adverse effects of antiretroviral therapy
Carr, A. D., & Cooper, D. A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02854-3 · Cited by 1,062 · see citing works
The effects of cannabinoids on the brain
Ameri, A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00087-2 · Cited by 805 · see citing works
Iversen, L. L. (2003) · Brain · doi:10.1093/brain/awg143 · Cited by 735 · see citing works
Cannabidiol: An Overview of Some Pharmacological Aspects
Mechoulam, R., Parker, L. A., & Gallily, R. (2002) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.2002.tb05998.x · Cited by 511 · see citing works
Wade, D. T., Robson, P., House, H., Makela, P., & Aram, J. (2003) · Clinical Rehabilitation · doi:10.1191/0269215503cr581oa · Cited by 441 · see citing works
An analgesia circuit activated by cannabinoids
Meng, I. D., Manning, B. H., Martin, W. J., & Fields, H. L. (1998) · Nature · doi:10.1038/26481 · Cited by 411 · see citing works
The analgesic properties of delta‐9‐tetrahydrocannabinol and codeine
Noyes, R., Brunk, S. F., Avery, D. H., & Canter, A. (1975) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt197518184 · Cited by 378 · see citing works
Antiemetic Effect of Delta-9-Tetrahydrocannabinol in Patients Receiving Cancer Chemotherapy
Sallan, S. E., Zinberg, N. E., & Frei, E. (1975) · New England Journal of Medicine · doi:10.1056/nejm197510162931603 · Cited by 364 · see citing works
Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
Pryce, G., Ahmed, Z., Hankey, D. J. R., Jackson, S. J., Croxford, J. L., Pocock, J. M., Ledent, C. A., Petzold, A., Thompson, A. J., Giovannoni, G., et al. (2003) · Brain · doi:10.1093/brain/awg224 · Cited by 342 · see citing works
Cannabinoids as Therapeutic Agents
(2019) · Chapman & Hall/CRC eBooks · doi:10.1201/9780429260667 · Cited by 311 · see citing works
The Guy's Neurological Disability Scale (GNDS): a new disability measure for multiple sclerosis
Sharrack, B., & Hughes, R. A. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500406 · Cited by 290 · see citing works
Delta-9-Tetrahydrocannabinol as an Antiemetic in Cancer Patients Receiving High-Dose Methotrexate
Chang, A. E., Shiling, D. J., Stillman, R. C., Goldberg, N. H., Seipp, C. A., Barofsky, I., Simon, R. M., & Rosenberg, S. A. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-6-819 · Cited by 258 · see citing works
Peripheral neuropathic pain—a multidimensional burden for patients
Meyer-Rosberg, K., Kvarnström, A., Kinnman, E., Gordh, T., Nordfors, L., & Kristofferson, A. (2001) · European Journal of Pain · doi:10.1053/eujp.2001.0259 · Cited by 247 · see citing works
Abrams, D. I., Hilton, J. F., Leiser, R. J., Shade, S. B., Elbeik, T. A., Aweeka, F. T., Benowitz, N. L., Bredt, B. M., Kosel, B., Aberg, J. A., et al. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-4-200308190-00008 · Cited by 238 · see citing works
Cannabinoids and brain injury: therapeutic implications
Mechoulam, R. (2002) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(02)02276-1 · Cited by 229 · see citing works
Recent clinical experience with dronabinol
Plasse, T. F., Gorter, R. W., Krasnow, S. H., Lane, M., Shepard, K. V., & Wadleigh, R. G. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90385-f · Cited by 225 · see citing works
HIV-associated sensory neuropathies
Keswani, S. C., Pardo, C. A., Cherry, C. L., Höke, A., & McArthur, J. C. (2002) · AIDS · doi:10.1097/00002030-200211080-00002 · Cited by 218 · see citing works
Cannabis use for chronic non-cancer pain: results of a prospective survey
Ware, M. A., Doyle, C. R., Woods, R., Lynch, M. E., & Clark, A. J. (2003) · Pain · doi:10.1016/s0304-3959(02)00400-1 · Cited by 185 · see citing works
Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy
Rice, A. S. C., Farquhar-Smith, W. P., & Nagy, I. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0362 · Cited by 183 · see citing works
Cannabinoids: a real prospect for pain relief
Iversen, L. L. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00120-5 · Cited by 162 · see citing works
Evaluation of Intramuscular Levonantradol and Placebo in Acute Postoperative Pain
Jain, A. K., Ryan, J. R., McMahon, F. G., & Smith, G. (1981) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1981.tb02610.x · Cited by 150 · see citing works
Different Effects of Nabilone and Cannabidiol on Binocular Depth Inversion in Man
Leweke, F. M., Schneider, U., Radwan, M., Schmidt, E., & Emrich, H. M. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00201-x · Cited by 150 · see citing works
Pain relief with oral cannabinoids in familial Mediterranean fever
Holdcroft, A., Smith, M., Jacklin, A., Hodgson, H. J. F., Smith, B., Newton, M., & Evans, F. J. (1997) · Anaesthesia · doi:10.1111/j.1365-2044.1997.139-az0132.x · Cited by 129 · see citing works
Self-citationEffect of a nitrogen analog of tetrahydrocannabinol on cancer pain
Staquet, M. J., Gantt, C., & Machin, D. (1978) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1978234397 · Cited by 87 · see citing works
Taylor, D. R., & Hall, W. (2003) · Internal Medicine Journal · doi:10.1046/j.1445-5994.2003.00401.x · Cited by 58 · see citing works
The Endocannabinoid System and Huntingtons Disease
Lastres‐Becker, I., Miguel, R., & Fernández‐Ruíz, J. (2003) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007033482751 · Cited by 54 · see citing works
Delta-9-Tetrahydrocannabinol in Cancer Chemotherapy: Research Problems and Issues
Carey, M. P., Burish, T. G., & Brenner, D. E. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-1-106 · Cited by 50 · see citing works
Cannabis Use by Persons Living with HIV/AIDS: Patterns and Prevalence of Use
Ware, M. A., Rueda, S., Singer, J., & Kilby, D. (2003) · Journal of Cannabis Therapeutics · doi:10.1300/j175v03n02_02 · Cited by 49 · see citing works
Δ9-Tetrahydrocannabinol in Clinical Oncology
Poster, D. S. (1981) · JAMA · doi:10.1001/jama.1981.03310450039020 · Cited by 41 · see citing works
Medical Use of Recreational Drugs by AIDS Patients
Dansak, D. A. (1997) · Journal of Addictive Diseases · doi:10.1300/j069v16n03_03 · Cited by 30 · see citing works
Marijuana Use in HIV-Positive and AIDS Patients
Sidney, S. (2001) · Journal of Cannabis Therapeutics · doi:10.1300/j175v01n03_04 · Cited by 18 · see citing works
Non-nucleoside reverse transcriptase inhibitors—an overview
Bell, C., Matthews, G. V., & Nelson, M. R. (2003) · International Journal of STD & AIDS · doi:10.1258/095646203321156827 · Cited by 12 · see citing works
Cannabis Therapeutics in HIV/AIDS
Russo, E. B. (2012) · Routledge eBooks · doi:10.4324/9780203049105 · Cited by 6 · see citing works
Cannabis Therapeutics in HIV/AIDS
Gomez-Beloz, A. (2003) · Economic Botany · doi:10.1663/0013-0001(2003)057[0425:bredfa]2.0.co;2 · Cited by 3 · see citing works
Flagged first, then by citations
2 of the 37 references couldn’t be matched to a known paper.
Research works printed but not linked: 7
- Ware MA, Rueda S, Kilby D, Singer J. Cannabis use among patients with HIV/AIDS: Patterns and prevalence of use. J Cannabis Ther 2003;3:3-15.
- Prestage GS, Kippax S, Grulich A. Use of treat- ments and health enhancement behaviours among HIV positive men in a cohort of homosexually active men. XI International Conference on AIDS, Vancouver, BC, Canada, July 1996. Abstract thD 5181.
- Sallan SE, Zinberg NE. Frei E 3rd. Anti-emetic effects of delta-9-tetrahydrocannabinol in patients re- ceiving cancer chemotherapy. N Engl J Med 1975; 293:795-797.
- Staquet M, Gantt C, Machin D. Effect of a nitro- gen analogue of tetrahydrocannabinol on cancer pain. Clin Pharm Ther 1978;23:397-401.
- Randall R. Marijuana, medicine and the law, Vol. II. Washington, DC: Galen Press, 1999.
- Abrams DI, Hilton JF, Leiser RJ, et al. Short-term effects of cannabinoids in patients with HIV-1 infec- tion. Ann Intern Med 2003;139:258-266.
- Mechoulam R, Panikashvili D, Shohami E. Can- nabinoids and brain injury: Therapeutic implica- tions. Trends Mol Med 2002;8:58-61.
Cited by
Sorted by citations
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077 · see citing works
Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 676 · see citing works
Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial
Abrams, D. I., Jay, C. A., Shade, S. B., Vizoso, H., Reda, H., Press, S., Kelly, M. E., Rowbotham, M. C., & Petersen, K. L. (2007) · Neurology · doi:10.1212/01.wnl.0000253187.66183.9c · Cited by 598 · see citing works
Pain and Depression: A Systematic Review
IsHak, W. W., Wen, R. Y., Naghdechi, L., Vanle, B., Dang, J., Knosp, M., Dascal, J., Marcia, L., Gohar, Y., Eskander, L., et al. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000198 · Cited by 498 · see citing works
Cannabis and anxiety: a critical review of the evidence
Crippa, J. A., Zuardi, A. W., Martín‐Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., & Fusar‐Poli, P. (2009) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.1048 · Cited by 509 · see citing works
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
Buckner, J. D., Keough, M. E., & Schmidt, N. B. (2007) · Addictive Behaviors · doi:10.1016/j.addbeh.2006.12.019 · Cited by 301 · see citing works
Reinarman, C., Nunberg, H., Lanthier, F., & Heddleston, T. (2011) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2011.587700 · Cited by 290 · see citing works
Inhaled Cannabis for Chronic Neuropathic Pain: A Meta-analysis of Individual Patient Data
Andreae, M. H., Carter, G. M., Shaparin, N., Suslov, K., Ellis, R. J., Ware, M. A., Abrams, D. I., Prasad, H., Wilsey, B. L., Indyk, D., et al. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.07.009 · Cited by 268 · see citing works
Phillips, T., Cherry, C. L., Cox, S., Marshall, S. J., & Rice, A. S. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014433 · Cited by 257 · see citing works
Medical cannabis and mental health: A guided systematic review
Walsh, Z., González, R., Crosby, K., Thiessen, M. S., Carroll, C., & Bonn‐Miller, M. O. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.10.002 · Cited by 247 · see citing works
Cannabinoids in health and disease
Kogan, N. M., & Mechoulam, R. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.4/nkogan · Cited by 227 · see citing works
Storr, M., Devlin, S. M., Kaplan, G. G., Panaccione, R., & Andrews, C. N. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000440982.79036.d6 · Cited by 207 · see citing works
Baron, E. P. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12570 · Cited by 205 · see citing works
Modulation of pain transmission by G-protein-coupled receptors
Pan, H., Wu, Z.-Z., Zhou, H.-Y., Chen, S.-R., Zhang, H., & Li, D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.003 · Cited by 197 · see citing works
Substance use: impact on adherence and HIV medical treatment
Gonzalez, A., Barinas, J., & O’Cleirigh, C. (2011) · Current HIV/AIDS Reports · doi:10.1007/s11904-011-0093-5 · Cited by 195 · see citing works
Dronabinol and Marijuana in HIV-Positive Marijuana Smokers: Caloric Intake, Mood, and Sleep
Haney, M., Gunderson, E. W., Rabkin, J., Hart, C. L., Vosburg, S. K., Comer, S. D., & Foltin, R. W. (2007) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31811ed205 · Cited by 184 · see citing works
Cannabis use amongst patients with inflammatory bowel disease
Lal, S., Prasad, N., Ryan, M., Tangri, S., Silverberg, M. S., GORDON, A. S., & Steinhart, H. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328349bb4c · Cited by 170 · see citing works
The molecular neurobiology of chronic pain–induced depression
Humo, M., Lu, H., & Yalçın, İ. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03003-z · Cited by 164 · see citing works
The analgesic potential of cannabinoids.
Elikottil, M., Gupta, M., & Gupta, P. (2018) · Journal of Opioid Management · doi:10.5055/jom.2009.0034 · Cited by 141 · see citing works
In the weeds: a baseline view of cannabis use among legalizing states and their neighbours
Pacula, R. L., Jacobson, M., & Hernandez, E. J. M. (2015) · Addiction · doi:10.1111/add.13282 · Cited by 138 · see citing works
Prevalence of cannabis use disorder diagnoses among veterans in 2002, 2008, and 2009.
Bonn‐Miller, M. O., Harris, A. H. S., & Trafton, J. A. (2012) · Psychological Services · doi:10.1037/a0027622 · Cited by 135 · see citing works
Endocannabinoid system: Role in depression, reward and pain control (Review)
Huang, W., Chen, W., & Zhang, X. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5585 · Cited by 135 · see citing works
Kramer, J. L. (2014) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21260 · Cited by 132 · see citing works
Stigma among California’s Medical Marijuana Patients
Satterlund, T. D., Lee, J. P., & Moore, R. S. (2015) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2014.991858 · Cited by 129 · see citing works
Adherence to HIV treatment among IDUs and the role of opioid substitution treatment (OST)
Spire, B., Lucas, G. M., & Carrieri, P. (2007) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2006.12.014 · Cited by 125 · see citing works
Littlewood, R. A., & Vanable, P. A. (2008) · AIDS Care · doi:10.1080/09540120701767216 · Cited by 120 · see citing works
Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease
Allegretti, J. R., Courtwright, A., Lucci, M., Korzenik, J. R., & LEVINE, J. S. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000435851.94391.37 · Cited by 119 · see citing works
Krolick, K. N., Zhu, Q., & Shi, H. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.07.008 · Cited by 121 · see citing works
Lever, I. J., & Rice, A. S. C. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_10 · Cited by 108 · see citing works
Cannabis use and HIV antiretroviral therapy adherence and HIV-related symptoms
Bonn‐Miller, M. O., Oser, M. L., Bucossi, M. M., & Trafton, J. A. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9458-5 · Cited by 99 · see citing works
Bruce, R. D., Merlin, J. S., Lum, P. J., Ahmed, E., Alexander, C. S., Corbett, A., Foley, K. M., Leonard, K., Treisman, G. J., & Selwyn, P. A. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix636 · Cited by 93 · see citing works
DʼSouza, G., Matson, P. A., Grady, C. D., Nahvi, S., Merenstein, D., Weber, K. M., Greenblatt, R. M., Burian, P., & Wilson, T. E. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e318273ab3a · Cited by 86 · see citing works
Patterns of cannabis use in patients with Inflammatory Bowel Disease: A population based analysis
Weiss, A., & Friedenberg, F. K. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.08.035 · Cited by 85 · see citing works
Naguib, M., Diaz, P., Xu, J. J., Astruc‐Diaz, F., Craig, S., Vivas‐Mejia, P., & Brown, D. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.340 · Cited by 82 · see citing works
The prevalence and incidence of medicinal cannabis on prescription in The Netherlands
Hazekamp, A., & Heerdink, E. R. (2013) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-013-1503-y · Cited by 81 · see citing works
The cannabinoid CB 1 receptor and the endocannabinoid anandamide: possible antidepressant targets
Bambico, F. R., & Gobbi, G. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.11.1347 · Cited by 80 · see citing works
Bedi, G., Foltin, R. W., Gunderson, E. W., Rabkin, J. G., Hart, C. L., Comer, S. D., Vosburg, S. K., & Haney, M. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1995-4 · Cited by 77 · see citing works
Bell, A. D., MacCallum, C., Margolese, S., Walsh, Z., Wright, P., Daeninck, P. J., Mandarino, E., Lacasse, G., Kaur Deol, J., de Freitas, L., et al. (2024) · Cannabis & Cannabinoid Research · doi:10.1089/can.2021.0156 · Cited by 78 · see citing works
“60 Three cross-sectional studies also report antidepressant effects of CBM. 82,97,98 Studies involving the use of cannabis extracts are generally less positive regarding the benefits of CBM for treating depression in people with chronic pain.”
BackgroundHerbal medicinal products or preparations for neuropathic pain
Boyd, A., Bleakley, C., Hurley, D. A., Gill, C. I. R., Hannon-Fletcher, M. P. A., Bell, P., & McDonough, S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010528.pub4 · Cited by 74 · see citing works
Symptom management and self-care for peripheral neuropathy in HIV/AIDS
Nicholas, P. K., Kemppainen, J. K., Canaval, G. E., Corless, I. B., Sefcik, E. F., Nokes, K. M., Bain, C. A., Kirksey, K. M., Eller, L. S., Dole, P. J., et al. (2007) · AIDS Care · doi:10.1080/09540120600971083 · Cited by 72 · see citing works
Cannabinoid control of neuroinflammation related to multiple sclerosis
Baker, D., Jackson, S. J., & Pryce, G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707458 · Cited by 69 · see citing works
Watson, C. W., Paolillo, E. W., Morgan, E. E., Umlauf, A., Sundermann, E. E., Ellis, R. J., Letendre, S. L., Marcotte, T. D., Heaton, R. K., & Grant, I. (2019) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000002211 · Cited by 66 · see citing works
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Maggirwar, S. B., & Khalsa, J. H. (2021) · Viruses · doi:10.3390/v13061099 · Cited by 67 · see citing works
Effects of cannabinoids and their receptors on viral infections
Tahamtan, A., Tavakoli‐Yaraki, M., Rygiel, T. P., Mokhtari‐Azad, T., & Salimi, V. (2015) · Journal of Medical Virology · doi:10.1002/jmv.24292 · Cited by 66 · see citing works
New Treatments for Neuropathic Pain
Rice, A. S. C., & Hill, R. G. (2006) · Annual Review of Medicine · doi:10.1146/annurev.med.57.121304.131324 · Cited by 65 · see citing works
Analysis of Factors Influencing the Ultrasonic Fetal Weight Estimation
Heer, I. M., Kümper, C., Vögtle, N., Müller-Egloff, S., Dugas, M., & Strauss, A. S. (2008) · Fetal Diagnosis and Therapy · doi:10.1159/000116742 · Cited by 63 · see citing works
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Kruger, D. J., & Kruger, J. S. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2018.1563314 · Cited by 61 · see citing works
Cannabis use in sickle cell disease: a questionnaire study
Howard, J., Anie, K. A., Holdcroft, A., Israeli‐Korn, S., & Davies, S. C. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05723.x · Cited by 61 · see citing works
Self-citationIs cannabis use associated with less opioid use among people who inject drugs?
Kral, A. H., Wenger, L. D., Novak, S. P., Chu, D., Corsi, K. F., Coffa, D. A., Shapiro, B. J., & Bluthenthal, R. N. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.014 · Cited by 58 · see citing works
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Meade, C. S., Drabkin, A. S., Hansen, N. B., Wilson, P. A., Kochman, A., & Sikkema, K. J. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03075.x · Cited by 57 · see citing works
Electrochemical sensing: A prognostic tool in the fight against COVID-19
Kotru, S., Klimuntowski, M., Ridha, H., Uddin, Z., Askhar, A. A., Singh, G., & Howlader, M. M. R. (2021) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2021.116198 · Cited by 56 · see citing works
Weber, J., Schley, M. T., Casutt, M., Gerber, H., Schuepfer, G., Rukwied, R., Schleinzer, W., Ueberall, M. A., & Konrad, C. J. (2009) · Anesthesiology Research and Practice · doi:10.1155/2009/827290 · Cited by 56 · see citing works
The Association Between Marijuana Use and HIV Continuum of Care Outcomes: a Systematic Review
Montgomery, L., Bagot, K. S., Brown, R., & Haeny, A. M. (2019) · Current HIV/AIDS Reports · doi:10.1007/s11904-019-00422-z · Cited by 56 · see citing works
Clinical Data for the Use of Cannabis-Based Treatments: A Comprehensive Review of the Literature
Inglet, S., Winter, B., Yost, S. E., Entringer, S., Lian, A., Biksacky, M., Pitt, R. D., & Mortensen, W. (2020) · Annals of Pharmacotherapy · doi:10.1177/1060028020930189 · Cited by 53 · see citing works
Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis
Wagner, E. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.01.003 · Cited by 54 · see citing works
Marijuana Effectiveness as an HIV Self-Care Strategy
Corless, I. B., Lindgren, T. G., Holzemer, W. L., Robinson, L. L., Moezzi, S., Kirksey, K. M., Coleman, C. L., Tsai, Y., Eller, L. S., Hamilton, M. J., et al. (2009) · Clinical Nursing Research · doi:10.1177/1054773809334958 · Cited by 50 · see citing works
HIV-1, methamphetamine and astrocytes at neuroinflammatory Crossroads
Borgmann, K., & Ghorpade, A. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01143 · Cited by 51 · see citing works
Marijuana effects on changes in brain structure and cognitive function among HIV+ and HIV− adults
Thames, A. D., Kuhn, T. P., Williamson, T. J., Jones, J. D., Mahmood, Z., & Hammond, A. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.11.007 · Cited by 51 · see citing works
Daily Cannabis Use is Associated With Lower CNS Inflammation in People With HIV
Watson, C. W., Campbell, L. M., Sun-Suslow, N., Hong, S., Umlauf, A., Ellis, R. J., Iudicello, J. E., Letendre, S. L., Marcotte, T. D., Heaton, R. K., et al. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617720001447 · Cited by 49 · see citing works
Slawson, G., Milloy, M., Balneaves, L. G., Simo, A., Guillemi, S. A., Hogg, R. S., Montaner, J. S. G., Wood, E., & Kerr, T. H. (2014) · AIDS and Behavior · doi:10.1007/s10461-014-0847-3 · Cited by 49 · see citing works
Jenny, M., Schröcksnadel, S., Überall, F., & Fuchs, D. (2010) · Pharmaceuticals · doi:10.3390/ph3082647 · Cited by 69 · see citing works
Estrogen rapidly attenuates cannabinoid-induced changes in energy homeostasis
Kellert, B., Nguyen, M. C., Nguyen, C., Nguyen, Q. H., & Wagner, E. J. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.09.001 · Cited by 45 · see citing works
Morgan, E., Khanna, A. S., Skaathun, B., Michaels, S., Young, L. E., Duvoisin, R., Chang, M., Voisin, D. R., Cornwell, B. T., Coombs, R. W., et al. (2016) · Substance Use & Misuse · doi:10.1080/10826084.2016.1197265 · Cited by 44 · see citing works
Prospects for the Use of Cannabinoids in Psychiatric Disorders
Graczyk, M., Łukowicz, M., & Dzierżanowski, T. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.620073 · Cited by 45 · see citing works
Kipp, A. M., Rebeiro, P. F., Shepherd, B. E., Brinkley‐Rubinstein, L., Turner, M. M., Bebawy, S. S., Sterling, T. R., & Hulgan, T. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1716-7 · Cited by 41 · see citing works
Gamble‐George, J., Conger, J. R., Hartley, N. D., Gupta, P., Sumislawski, J. J., & Patel, S. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3042-8 · Cited by 39 · see citing works
Cannabinoid-induced hyperphagia: Correlation with inhibition of proopiomelanocortin neurons?
Ho, J., Cox, J. M., & Wagner, E. J. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.028 · Cited by 37 · see citing works
Sex differences in the cannabinoid regulation of energy homeostasis
Farhang, B., Diaz, S. V., Tang, S. L., & Wagner, E. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.007 · Cited by 37 · see citing works
Munawar, N., Oriowo, M. A., & Masocha, W. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00136 · Cited by 36 · see citing works
Mlost, J., Wąsik, A., & Starowicz, K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.029 · Cited by 36 · see citing works
Cannabis sativaand the Endogenous Cannabinoid System: Therapeutic Potential for Appetite Regulation
Farrimond, J. A., Mercier, M. S., Whalley, B. J., & Williams, C. M. (2011) · Phytotherapy Research · doi:10.1002/ptr.3375 · Cited by 36 · see citing works
A Proteomic View of Cellular and Molecular Effects of Cannabis
Abyadeh, M., Gupta, V., Paulo, J. A., Gupta, V. B., Chitranshi, N., Godinez, A., Saks, D., Hasan, M. T., Amirkhani, A., McKay, M. J., et al. (2021) · Biomolecules · doi:10.3390/biom11101411 · Cited by 35 · see citing works
Possible therapeutic applications of cannabis in the neuropsychopharmacology field
Fernández‐Ruíz, J., Galve‐Roperh, I., Sagredo, O., & Guzmán, M. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.01.013 · Cited by 34 · see citing works
Treatment Considerations in Painful HIV-Related Neuropathy
Smith, H. S. (2011) · Pain Physician · doi:10.36076/ppj.2011/14/e505 · Cited by 34 · see citing works
Borgquist, A., Meza, C., & Wagner, E. J. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00421.2014 · Cited by 33 · see citing works
Lake, S., Kerr, T. H., Capler, R., Shoveller, J., Montaner, J. S. G., & Milloy, M. (2017) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2017.02.009 · Cited by 33 · see citing works
Unhealthy behaviours for self-management of HIV-related peripheral neuropathy
Nicholas, P. K., Voss, J. G., Corless, I. B., Lindgren, T. G., Wantland, D. J., Kemppainen, J. K., Canaval, G. E., Sefcik, E. F., Nokes, K. M., Bain, C. A., et al. (2007) · AIDS Care · doi:10.1080/09540120701408928 · Cited by 32 · see citing works
Peball, M., Werkmann, M., Ellmerer, P., Stolz, R., Valent, D., Knaus, H., Ulmer, H., Djamshidian, A., Poewe, W. H., & Seppi, K. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02021-z · Cited by 31 · see citing works
Kostanda, E., & Khatib, S. (2021) · Industrial Crops and Products · doi:10.1016/j.indcrop.2021.114331 · Cited by 31 · see citing works
Neuroimmunity, Drugs of Abuse, and neuroAIDS
Burdo, T. H., Katner, S. N., Taffe, M. A., & Fox, H. S. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-005-9001-3 · Cited by 31 · see citing works
Skalski, L. M., Towe, S. L., Sikkema, K. J., & Meade, C. S. (2017) · Current Drug Abuse Reviews · doi:10.2174/1874473709666160502124503 · Cited by 30 · see citing works
Carey, L. M., Xu, Z., Rajic, G., Makriyannis, A., Romero, J., Hillard, C. J., Mackie, K., & Hohmann, A. G. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106560 · Cited by 30 · see citing works
Alternatives to Atypical Antipsychotics for the Management of Dementia-Related Agitation
Passmore, M. J., Gardner, D. M., Polak, Y., & Rabheru, K. (2008) · Drugs & Aging · doi:10.2165/00002512-200825050-00003 · Cited by 30 · see citing works
Herbst, J., & Musgrave, G. (2019) · Journal of the American Pharmacists Association · doi:10.1016/j.japh.2019.09.023 · Cited by 30 · see citing works
CBD and THC in Special Populations: Pharmacokinetics and Drug–Drug Interactions
Qian, L., Beers, J. L., Jackson, K. D., & Zhou, Z. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040484 · Cited by 30 · see citing works
The role of cannabinoids in pain control: the good, the bad, and the ugly
Pergolizzi, J. V., LeQuang, J. A., Taylor, R., Raffa, R. B., & Colucci, D. R. (2018) · Minerva Anestesiologica · doi:10.23736/s0375-9393.18.12287-5 · Cited by 29 · see citing works
Tsao, J. C. I., Stein, J. A., Ostrow, D. G., Stall, R. D., & Plankey, M. W. (2011) · Pain · doi:10.1016/j.pain.2011.08.024 · Cited by 28 · see citing works
Mannes, Z. L., Burrell, L. E., Ferguson, E. G., Zhou, Z. H., Lu, H., Somboonwit, C., Cook, R. L., & Ennis, N. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s167826 · Cited by 28 · see citing works
Benefits, toxicity and current market of cannabidiol in edibles
Astray, G., Mejuto, J. C., Xiao, J., & Simal‐Gándara, J. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.2024493 · Cited by 27 · see citing works
Washburn, N., Borgquist, A., Wang, K., Jeffery, G. S., Kelly, M. J., & Wagner, E. J. (2012) · Neuroendocrinology · doi:10.1159/000338669 · Cited by 27 · see citing works
Okafor, C. N., Cook, R. L., Chen, X., Surkan, P. J., Becker, J. T., SHOPTAW, S. J., Martin, E. M., & Plankey, M. W. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1245738 · Cited by 24 · see citing works
Aly, E., & Masocha, W. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2021.01.004 · Cited by 22 · see citing works
Neuroimaging the Neuropathogenesis of HIV
Boerwinkle, A. H., Meeker, K. L., Luckett, P. H., & Ances, B. M. (2021) · Current HIV/AIDS Reports · doi:10.1007/s11904-021-00548-z · Cited by 22 · see citing works
Skalski, L. M., Towe, S. L., Sikkema, K. J., & Meade, C. S. (2017) · AIDS and Behavior · doi:10.1007/s10461-017-1898-z · Cited by 21 · see citing works
Molina, P. E., Amedee, A. M., Winsauer, P. J., Nelson, S., Bagby, G., & Simon, L. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9599-8 · Cited by 20 · see citing works
Wardell, J. D., Shuper, P. A., & Hendershot, C. S. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.08.026 · Cited by 20 · see citing works
Symptomatic treatment of multiple sclerosis using cannabinoids: recent advances
Smith, P. F. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.9.1157 · Cited by 20 · see citing works
Amedee, A. M., Nichols, W. A., LeCapitaine, N. J., Stouwe, C. V., Birke, L. L., Lacour, N., Winsauer, P. J., & Molina, P. E. (2014) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2014.0108 · Cited by 19 · see citing works
- Authors
- Woolridge, E., Barton, S., Samuel, J., Osorio, J., Dougherty, A., & Holdcroft, A.
- Affiliations
- Imperial College London (GB)
- Chelsea and Westminster Hospital (GB)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- ORCID
- Barton, Simon
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 29
- Issue
- 4
- Pages
- 358-367
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2115233771
- Cited by
- 208
- References
- 37
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 4 · 2023: 21 · 2022: 12 · 2021: 18 · 2020: 5 · 2019: 11 · 2018: 8 · 2017: 10 · 2016: 9 · 2015: 15 · 2014: 11 · 2013: 7 · 2012: 9
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- cannabis use, HIV infection, symptom management, neuropathic pain, neuropathy, appetite, nausea, anxiety, depression, paresthesia, antiretroviral therapy adverse effects, memory impairment
- MeSH terms
- Adult, Aged, Cannabinoids, Cannabis, Cross-Sectional Studies, Data Collection, Drug Therapy, Female, United Kingdom, Humans, Male, Phytotherapy, Middle Aged, Nausea, Pain, Severity of Illness Index, HIV Infections, Comorbidity, Plant Preparations
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