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Cited by 318Heart Failure Treatment and ManagementCardiac Health and Mental HealthPalliative Care and End-of-Life Issues

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Symptom Distress and Quality of Life in Patients with Advanced Congestive Heart Failure

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Blinderman, Craig D., Homel, Peter, Billings, J. Andrew, Portenoy, Russell K., Tennstedt, Sharon L.·2008·Journal of Pain and Symptom Management
DOI 10.1016/j.jpainsymman.2007.06.007PMC PMC2662445
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Abstract

Little is known about the burden of illness associated with advanced congestive heart failure (CHF). Understanding the needs of this population requires further information about symptoms and other factors related to quality of life. We studied a convenience sample of 103 community-dwelling patients with New York Heart Association Class III/IV CHF. The primary outcome, quality of life, was measured with the Multidimensional Index of Life Quality. Potential correlates of quality of life included overall symptom burden (Memorial Symptom Assessment Scale, MSAS), including global symptom distress (MSAS Global Distress Index, GDI); psychological state (Mental Health Inventory-5); functional status (Sickness Impact Profile); spirituality (Functional Assessment of Chronic Illness Therapy-Spirituality Scale); and co-morbid conditions (Charlson Comorbidity Index). Patients had a mean age of 67.1 years (SD=12.1); were mostly white (72.8%), male (71.8%), and married (51.5%); and had a mean ejection fraction of 22.3% (SD=6.8). The most prevalent symptoms were lack of energy (66%), dry mouth (62%), shortness of breath (56%), and drowsiness (52%). Pain was reported by about one-third of patients. For each of these symptoms, high symptom-related distress was reported by 14.1%-54.1%. Quality of life was moderately compromised (Multidimensional Index of Life Quality composite, median=56, possible range 12-84). Impairment in quality of life was strongly associated with global symptom distress (MSAS GDI; r=0.74, P<0.001); burden of comorbid conditions (r = -0.32, P=0.002), female sex (r=-0.22, P=0.03), functional impairment, particularly psychological impairment (r=-0.55, P<0.001), and poorer psychological well-being (r=0.68, P<0.001). In multivariate analyses, impairment in quality of life was significantly related to high symptom distress, poorer psychological well-being, and poor functional mobility (R2=0.67; P=0.002 for all). Distressful symptoms related to impaired quality of life included lack of energy (P=0.04), irritability (P=0.03), and drowsiness (P=0.02). Community-dwelling patients with advanced CHF experience numerous symptoms, significant symptom distress, and a compromised quality of life. Overall quality of life was strongly associated with symptom distress, psychological well-being and functional status. A focus on ameliorating prevalent physical symptoms and psychological distress, along with supportive measures that promote functional mobility, may lead to an improvement in the overall quality of life in this patient population.

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  1. Levenson, 2000, The last six months of life for patients with chronic heart failure, J Am Geriatr Soc, 5, S101

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Metadata

Authors
Blinderman, C. D., Homel, P., Billings, J. A., Portenoy, R. K., & Tennstedt, S. L.
Affiliations
  • Harvard University (US)
  • Mount Sinai Beth Israel (US)
  • New England Research Institutes (US)
Corresponding author
Blinderman, Craig D.
ORCID
Venue
Journal of Pain and Symptom Management
Publisher
Elsevier BV
Published
2008-06
Volume
35
Issue
6
Pages
594-603
ISSN
0885-3924 (ISSN-L)
DOI
10.1016/j.jpainsymman.2007.06.007
PMC
PMC2662445
OpenAlex
W2055107847
Cited by
318
References
33
Citations by year
2026: 6 · 2025: 6 · 2024: 15 · 2023: 18 · 2022: 13 · 2021: 19 · 2020: 19 · 2019: 20 · 2018: 12 · 2017: 27 · 2016: 30 · 2015: 24 · 2014: 21 · 2013: 15 · 2012: 25
FWCI
11.40
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Pain and Symptom Management (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Nursing Research (R01NR005154, NR05154)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
Keywords
congestive heart failure, advanced heart failure, quality of life, symptom distress, symptom burden, psychological well-being, functional status, comorbidities, spirituality, lack of energy, dyspnea, sleepiness, pain, community-dwelling patients, disease burden, sex differences, functional mobility, Memorial Symptom Assessment Scale, Sickness Impact Profile
MeSH terms
Aged, Cardiomyopathy, Dilated, Female, Humans, Longitudinal Studies, Male, Mental Health, Middle Aged, Prospective Studies, Quality of Life, Surveys and Questionnaires, Regression Analysis, Comorbidity, Sickness Impact Profile, Spirituality

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