Cited by 237Connective tissue disorders researchMusculoskeletal pain and rehabilitationPediatric Pain Management Techniques

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Pain in Ehlers-Danlos Syndrome Is Common, Severe, and Associated with Functional Impairment

Open access

Voermans, Nicol C., Knoop, Hans, Bleijenberg, Gijs, van Engelen, Baziel G.·2010·Journal of Pain and Symptom Management

DOI 10.1016/j.jpainsymman.2009.12.026

Open this paper in CoChat — free account Open PDF

Abstract

Context The Ehlers-Danlos Syndrome (EDS) is a clinically and genetically heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Musculoskeletal pain is mentioned in the diagnostic criteria and described as early in onset, chronic, and debilitating. However, systematic research on pain in EDS is scarce.Objectives We investigated prevalence and impact of pain and associated features in a large group of EDS patients.Methods We performed a study among members of the Dutch EDS patient organization (n=273) and included the McGill Pain Questionnaire to investigate various aspects of pain, the Sickness Impact Profile to study functional impairment, the Symptom Checklist subscale sleep to evaluate sleep disturbances, and the Checklist Individual Strength subscale fatigue to determine fatigue severity.Results The results of this study show that 1) chronic pain in EDS is highly prevalent and associated with regular use of analgesics; 2) pain is more prevalent and more severe in the hypermobility type than in the classic type; 3) pain severity is correlated with hypermobility, dislocations, and previous surgery; 4) pain is correlated with low nocturnal sleep quality; and 5) pain contributes to functional impairment in daily life, independent of the level of fatigue.Conclusion From this large cohort of EDS patients, we conclude that pain is common and severe in EDS. Pain is related to hypermobility, dislocations, and previous surgery and associated with moderate to severe impairment in daily functioning. Therefore, treatment of pain should be a prominent aspect of symptomatic management of EDS.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jpainsymman.2009.12.026

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

SF-36 health survey: Manual and interpretation guide
Ware, J. (2003) · Medical Entomology and Zoology · Cited by 11,424
The McGill Pain Questionnaire: Major properties and scoring methods
Melzack, R. (1975) · Pain · doi:10.1016/0304-3959(75)90044-5 · Cited by 6,873
Systematic review and meta-analysis of randomized controlled trials of cognitive behaviour therapy and behaviour therapy for chronic pain in adults, excluding headache
Morley, S., Eccleston, C., & Williams, A. (1999) · Pain · doi:10.1016/s0304-3959(98)00255-3 · Cited by 1,597
Dimensional assessment of chronic fatigue syndrome
Vercoulen, J. H. M. M., Swanink, C. M. A., Fennis, J. F. M., Galama, J. M. D., van der Meer, J. W. M., & Bleijenberg, G. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90099-x · Cited by 1,306
Self-citation
Psychological aspects of persistent pain: Current state of the science
Keefe, F. J., Rumble, M. E., Scipio, C. D., Giordano, L. A., & Perri, L. M. (2004) · The Journal of Pain · doi:10.1016/j.jpain.2004.02.576 · Cited by 954
Connective Tissue and Its Heritable Disorders
Heinegård, D., Aspberg, A., Franzén, A., & Lorenzo, P. (2002) · Wiley eBooks · doi:10.1002/0471221929 · Cited by 946
A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency
Schalkwijk, J., Zweers, M. C., Steijlen, P. M., Dean, W. B., Taylor, G., van Vlijmen, I. M., van Haren, B., Miller, W. L., & Bristow, J. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa002939 · Cited by 391
Tenascin-X deficiency is associated with Ehlers-Danlos syndrome
Burch, G. H., Gong, Y., Liu, W., Dettman, R. W., Curry, C. J., Smith, L., Miller, W. L., & Bristow, J. (1997) · Nature Genetics · doi:10.1038/ng0997-104 · Cited by 366
The Ehlers‐Danlos Syndrome
Steinmann, B., Royce, P. M., & Superti‐Furga, A. (2002) · Connective Tissue and Its Heritable Disorders · doi:10.1002/0471221929.ch9 · Cited by 358
Estimating the clinical effectiveness of cognitive behavioural therapy in the clinic: Evaluation of a CBT informed pain management programme
Morley, S., Williams, A., & Hussain, S. (2008) · Pain · doi:10.1016/j.pain.2008.02.025 · Cited by 194

Show all 26 references

Research works printed but not linked: 4

Baakman WBE. [Quality of life in patients with Ehlers-Danlos syndrome]. [Dutch]. Thesis. Utrecht: University of Utrecht, Health Psychology, 2002.
Arrindell, 1986, Lisse: Swets & Zeitlinger
Berger, 1981, [German]. Z Psychosom Med Psychoanal, 27, 45
Jacobs, 1990, Ned Tijdschr Geneeskd, 134, 1950

Sorted by citations

Items 101–200 of 237

Clinical characteristics of patients with hypermobile type Ehlers–Danlos syndrome (hEDS) and generalized hypermobility spectrum disorders (G-HSD): an online survey
Teran-Wodzinski, P. C., & Kumar, A. (2023) · Rheumatology International · doi:10.1007/s00296-023-05378-3 · Cited by 22
Chronic pain in Noonan Syndrome: A previously unreported but common symptom
Vegunta, S., Cotugno, R., Williamson, A., & Grebe, T. A. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37337 · Cited by 21
Managing Chronic Pain in a Young Adolescent Girl with Ehlers-Danlos Syndrome
Branson, J. A., Kozlowska, K., Kaczynski, K. J., & Roesler, T. A. (2011) · Harvard Review of Psychiatry · doi:10.3109/10673229.2011.614484 · Cited by 19
Online pain management programs for chronic, widespread musculoskeletal conditions: a systematic review with meta-analysis
Chew, M. T., Chan, C., Kobayashi, S., Cheng, H. Y., Wong, T. M., & Nicholson, L. L. (2023) · Pain Practice · doi:10.1111/papr.13227 · Cited by 18
Joint hypermobility syndrome (a.k.a. Ehlers-Danlos Syndrome, Hypermobility Type): an updated critique.
Castori, M. (2013) · PubMed · Cited by 18
Pain and sleep quality in children with non‐vascular Ehlers–Danlos syndromes
Muriello, M. J., Clemens, J. L., Mu, W., Tran, P. T., Rowe, P. C., Smith, C. H., Francomano, C. A., Bodurtha, J. N., & Kline, A. D. (2018) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.40371 · Cited by 19
Pharmacological Treatment of Chronic Non-Cancer Pain in Pediatric Patients
Mathew, E. S., Kim, E. S., & Goldschneider, K. R. (2014) · Pediatric Drugs · doi:10.1007/s40272-014-0092-2 · Cited by 17
Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome
Okuda‐Ashitaka, E., Kakuchi, Y., Kakumoto, H., Yamanishi, S., Kamada, H., Yoshidu, T., Matsukawa, S., Ogura, N., Uto, S., Minami, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63499-2 · Cited by 17
Evaluation of temporomandibular disorders and comorbidities in patients with Ehler-–Danlos: Clinical and digital findings
Giacomo, P. D., Celli, M., Ierardo, G., Polimeni, A., & Paolo, C. D. (2018) · Journal of International Society of Preventive and Community Dentistry · doi:10.4103/jispcd.jispcd_103_18 · Cited by 16
Joint Hypermobility among Female Patients Presenting with Chronic Myofascial Pelvic Pain
Hastings, J., Forster, J. E., & Witzeman, K. A. (2019) · PM&R · doi:10.1002/pmrj.12131 · Cited by 16
An acquired or heritable connective tissue disorder? A review of hypermobile Ehlers Danlos Syndrome
Martin, A. (2019) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2019.103672 · Cited by 19
Psychosocial and Motor Characteristics of Patients With Hypermobility
Lamari, M. M., Lamari, N. M., Filho, G. M. D. A., de Medeiros, M. P., Marques, V. R. P., & Pavarino, É. C. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.787822 · Cited by 16
Surgical Recommendations in Ehlers-Danlos Syndrome(s) Need Patient Classification: The Example of Ehlers-Danlos Syndrome Hypermobility Type (a.k.a. Joint Hypermobility Syndrome)
Castori, M. (2012) · Digestive Surgery · doi:10.1159/000346068 · Cited by 15
Pathogenic mechanisms in genetically defined Ehlers–Danlos syndromes
Syx, D., & Malfait, F. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.06.001 · Cited by 15
Shoulder arthroplasty is a viable option in patients with Ehlers-Danlos syndrome
Rogers, T., Werthel, J.-D., Crowe, M. M., Ortiguera, C. J., Elhassan, B. T., Sperling, J. W., Sánchez‐Sotelo, J., & Schoch, B. S. (2021) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2021.03.146 · Cited by 14
Multidisciplinary Chronic Pain Management Strategies in Patients with Ehlers–Danlos Syndromes
Gullapalli, P. A., & Javed, S. (2022) · Pain Management · doi:10.2217/pmt-2022-0050 · Cited by 14
Evaluation of lower limb disability in joint hypermobility syndrome
Celletti, C., Castori, M., Grammatico, P., & Camerota, F. (2011) · Rheumatology International · doi:10.1007/s00296-011-2044-2 · Cited by 14
Tendon protein synthesis rate in classic Ehlers-Danlos patients can be stimulated with insulin-like growth factor-I
Nielsen, R. H., Holm, L., Jensen, J. K., Heinemeier, K. M., Remvig, L., & Kjær, M. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00157.2014 · Cited by 11
Prevalence and correlates of pain in fatigued patients with type 1 diabetes
Menting, J., Tack, C. J., & Knoop, H. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.02.010 · Cited by 13
Self-citation
Clinical Characteristics of 100 Patients With Hypermobility Spectrum Disorders and Shoulder Complaints With or Without Mechanical Symptoms: A Cross-sectional Study
Liaghat, B., Skou, S. T., Søndergaard, J., Boyle, E., Søgaard, K., & Juul‐Kristensen, B. (2022) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2021.12.021 · Cited by 13
A narrative review of the literature on illness uncertainty in hypermobile ehlers-danlos syndrome: implications for research and clinical practice
Feldman, E. C. H., Homan, K. J., Williams, S. E., Ting, T. V., Goldschneider, K. R., & Kashikar‐Zuck, S. (2023) · Pediatric Rheumatology · doi:10.1186/s12969-023-00908-6 · Cited by 15
Bone parameters in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder: A comparative cross-sectional study
Coussens, M., Banica, T., Lapauw, B., Wandele, I. D., Rombaut, L., Malfait, F., & Calders, P. (2022) · Bone · doi:10.1016/j.bone.2022.116583 · Cited by 13
Exploring pain mechanisms in hypermobile Ehlers‐Danlos syndrome: A case–control study
Wandele, I. D., Colman, M., Hermans, L., Oosterwijck, J. V., Meeus, M., Rombaut, L., Brusselmans, G., Syx, D., Calders, P., & Malfait, F. (2022) · European Journal of Pain · doi:10.1002/ejp.1956 · Cited by 12
Patient experience of chronic illness care and complementary integrative health use: a cross-sectional study of patients with hypermobility spectrum disorders (HSD) and Ehlers–Danlos syndromes (EDS)
Guedry, S. E., Langley, B. O., Schaefer, K., & Hanes, D. A. (2022) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2131003 · Cited by 12
A Comprehensive Review: Chronic Pain Sequelae in the Presence of Ehlers–Danlos Syndrome
Basem, J. I., Lin, T. F., & Mehta, N. D. (2022) · Current Pain and Headache Reports · doi:10.1007/s11916-022-01093-z · Cited by 11
Anesthetic Management of a Patient With Ehlers-Danlos Syndrome
Ohshita, N., Kanazumi, M., Tsuji, K., Yoshida, H., Morita, S., Momota, Y., & Tsutsumi, Y. M. (2016) · Anesthesia Progress · doi:10.2344/16-00003.1 · Cited by 11
Does Muscle Strength Change Over Time in Patients With Hypermobile Ehlers‐Danlos Syndrome/Hypermobility Spectrum Disorder? An Eight‐Year Follow‐Up Study
Coussens, M., Calders, P., Lapauw, B., Celie, B., Banica, T., De Wandele, I., Pacey, V., Malfait, F., & Rombaut, L. (2021) · Arthritis Care & Research · doi:10.1002/acr.24220 · Cited by 11
Ehlers–Danlos Syndromes
Burrows, N. (2019) · Wiley eBooks · doi:10.1002/9781119142812.ch93 · Cited by 11
Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers–Danlos syndrome
Kamada, H., Emura, K., Yamamoto, R., Kawahara, K., Uto, S., Minami, T., Ito, S., Matsumoto, K., & Okuda‐Ashitaka, E. (2023) · Scientific Reports · doi:10.1038/s41598-023-45638-7 · Cited by 10
Lack of Diversity in Research on Females with Ehlers-Danlos Syndromes: Recruitment Protocol for a Quantitative Online Survey
Glayzer, J. E., Bray, B. C., Kobak, W. H., Steffen, A. D., & Schlaeger, J. M. (2024) · JMIR Research Protocols · doi:10.2196/53646 · Cited by 10
Muscle Strength, Muscle Mass and Physical Impairment in Women with hypermobile Ehlers-Danlos syndrome and Hypermobility Spectrum Disorder.
Coussens, M., Lapauw, B., Banica, T., Wandele, I. D., Pacey, V., Rombaut, L., Malfait, F., & Calders, P. (2022) · PubMed Central · Cited by 10
Pain Characteristics and Symptom Management in Children with Hypermobile Ehlers–Danlos Syndrome and Hypermobility Spectrum Disorder
Jeong, H., Engel, J. M., Wilwert, O., Muriello, M. J., Basel, D., & Slavens, B. A. (2023) · Physical & Occupational Therapy In Pediatrics · doi:10.1080/01942638.2022.2163601 · Cited by 10
Left to themselves: Time to target chronic pain in childhood rare diseases
Sieberg, C. B., Lebel, A., Silliman, E., Holmes, S. A., Borsook, D., & Elman, I. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.008 · Cited by 11
Ehlers-Danlos Syndromes
Lamari, N. M., & Beighton, P. (2023) · In clinical practice · doi:10.1007/978-3-031-34914-0_7 · Cited by 10
Prolonged standing behaviour in people with joint hypermobility syndrome
Bates, A. V., McGregor, A. H., & Alexander, C. M. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04744-1 · Cited by 9
Longitudinal analysis of symptoms in the Ehlers‐Danlos syndromes
Schubart, J. R., Mills, S. E., Schaefer, É., Bascom, R., & Francomano, C. A. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62640 · Cited by 10
Effects of Rhythmic Sensory Stimulation on Ehlers–Danlos Syndrome: A Pilot Study
Vuong, V., Mosabbir, A., Paneduro, D., Picard, L. M., Faghfoury, H., Evans, M., GORDON, A. S., & Bartel, L. (2020) · Pain Research and Management · doi:10.1155/2020/3586767 · Cited by 9
Sensory Profiling in Classical Ehlers-Danlos Syndrome: A Case-Control Study Revealing Pain Characteristics, Somatosensory Changes, and Impaired Pain Modulation
Colman, M., Syx, D., Wandele, I. D., Rombaut, L., Wille, D., Malfait, Z., Meeus, M., Malfait, A., Oosterwijck, J. V., & Malfait, F. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.06.015 · Cited by 8
Proteomic discoveries in hypermobile Ehlers–Danlos syndrome reveal insights into disease pathophysiology
Griggs, M., Daylor, V., Petrucci, T., Weintraub, A., Huff, M. L., Willey, S., Byerly, K., Loizzi, B., Morningstar, J. E., Ball, L. E., et al. (2025) · ImmunoHorizons · doi:10.1093/immhor/vlaf044 · Cited by 8
The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study
Bénistan, K., Pontier, B., Leblond, C., Flageul, O., Guicher, G. L., Enjalbert, M., & Gillas, F. (2023) · Healthcare · doi:10.3390/healthcare11131862 · Cited by 6
A qualitative study of pain and related symptoms experienced by people with Ehlers-Danlos syndromes
Schubart, J. R., Mills, S. E., Francomano, C. A., & Stuckey, H. L. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2023.1291189 · Cited by 11
Societal participation in ehlers-danlos syndromes and hypermobility spectrum disorder, compared to fibromyalgia and healthy controls
Baets, S. D., Cruyt, E., Calders, P., Wandele, I. D., Malfait, F., Vanderstraeten, G., Hove, G. V., & VELDE, D. V. D. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269608 · Cited by 10
Pain in Ehlers–Danlos Syndrome: A Non-Diagnostic Disabling Symptom?
Guerrieri, V., Polizzi, A., Caliogna, L., Brancato, A. M., Bassotti, A., Torriani, C., Jannelli, E., Mosconi, M., Grassi, F. A., & Pasta, G. (2023) · Healthcare · doi:10.3390/healthcare11070936 · Cited by 8
Chronic pain in a patient with Ehlers-Danlos syndrome (hypermobility type): The role of myofascial trigger point injections
Tewari, S., Madabushi, R., Agarwal, A., Gautam, S. K. S., & Khuba, S. (2016) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2016.06.017 · Cited by 6
The role of functional disability and social support in psychological outcomes for individuals with pediatric hypermobile ehlers–danlos syndrome
Bieniak, K. H., Tinkle, B. T., & Tran, S. T. (2022) · Journal of Child Health Care · doi:10.1177/13674935221143822 · Cited by 7
Ehlers-Danlos Syndrome or Disease?
(2015) · Journal of Syndromes · doi:10.13188/2380-6036.1000005 · Cited by 6
A study of UK physiotherapists’ knowledge and training needs in hypermobility and hypermobility syndrome
Lyell, M. J., Simmonds, J. V., & Deane, J. A. (2016) · Physiotherapy Practice and Research · doi:10.3233/ppr-160073 · Cited by 7
On Pins and Needles: Complex Pain and Malnutrition
Purkaple, B. A., & Middleman, A. B. (2016) · Clinical Pediatrics · doi:10.1177/0009922816656629 · Cited by 7
Skeletal muscle morphology, protein synthesis, and gene expression in Ehlers-Danlos syndrome
Nygaard, R. H., Jensen, J. K., Voermans, N. C., Heinemeier, K. M., Schjerling, P., Holm, L., Agergaard, J., Mackey, A. L., Andersen, J. L., Remvig, L., et al. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01044.2016 · Cited by 6
Self-citation
Ehlers-Danlos Syndrome: It’s Not Your Normal Hoofbeats
Hein, L. C., DeGregory, C., & Umari, F. (2019) · The Journal for Nurse Practitioners · doi:10.1016/j.nurpra.2019.01.006 · Cited by 6
The Spectrum of Pediatric Osteoporosis
Bianchi, M. L., & Glorieux, F. H. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382040-2.10018-8 · Cited by 6
Somatic symptoms, pain, catastrophizing and the association with disability among children with heritable connective tissue disorders
de Koning, L. E., Warnink‐Kavelaars, J., van Rossum, M. A. J., Bosman, D. K., Menke, L. A., Malfait, F., de Boer, R., Oosterlaan, J., Engelbert, R., Rombaut, L., et al. (2023) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.63204 · Cited by 5
Identification of a de novo case of COL5A1 ‐related Ehlers‐Danlos syndrome in an infant in the West Indies leading to improved targeted clinical care
Wardeh, A. H., Jackson, T., Nelson, B., Ernst, C., Théroux, J., Al‐Hertani, W., Sobering, A. K., & Maj, M. C. (2018) · Clinical Case Reports · doi:10.1002/ccr3.1873 · Cited by 4
Healthcare utilization among youth with Ehlers–Danlos syndrome hypermobile type
Williams, S. E., Tran, S. T., Lynch-Jordan, A. M., Goldschneider, K. R., Ting, T. V., Kashikar‐Zuck, S., & Neilson, D. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62625 · Cited by 5
Lumbar artificial disc replacement in Ehlers-Danlos syndrome: A case report and discussion of clinical management
Lindley, E. M., Patti, B. N., Taylor, M. R., Burger, E. L., & Patel, V. V. (2012) · The International Journal of Spine Surgery · doi:10.1016/j.ijsp.2012.02.006 · Cited by 5
The Impact of Pain on Everyday Activities of People With Hypermobility Spectrum Disorders or Hypermobility Ehlers Danlos Syndrome
Lindholm, S., Petersson, S., Molander, P., & Björk, M. (2025) · European Journal of Pain · doi:10.1002/ejp.70000 · Cited by 4
Treatments related to temporomandibular disorders among patients with prevalent types of Ehlers-Danlos syndrome in Sweden
Yekkalam, N., Novo, M., & Wänman, A. (2024) · CRANIO® · doi:10.1080/08869634.2024.2319565 · Cited by 4
Increased Opioid Use in Patients With Ehlers-Danlos Syndrome Before and After Total Hip Arthroplasty
Kelly, M., Kagan, R. P., & Yoo, J. U. (2024) · Arthroplasty Today · doi:10.1016/j.artd.2024.101390 · Cited by 4
Exploring fatigue in Marfan and hypermobile Ehlers-Danlos syndromes: an analytical cross-sectional study in two Italian healthcare centres
Udugampolage, N. S., Taurino, J., Bassotti, A., Pini, A., Caruso, R., Callus, E., Magon, A., Conte, G., Angeli, G. D., Paglione, G., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087298 · Cited by 4
Application of immunotherapy for neurological manifestations in hypermobile Ehlers–Danlos syndrome
Araki, M., Lin, Y., Ono, H., Sato, W., & Yamamura, T. (2018) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418793766 · Cited by 5
Fear avoidance, fear of falling, and pain disability in hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders
Chuchin, J., & Ornstein, T. J. (2023) · Disability and Rehabilitation · doi:10.1080/09638288.2023.2268520 · Cited by 5
Treating pain in patients with Ehlers–Danlos syndrome
Börsch, N., Mücke, M., Maier, A., Conrad, R., Pantel, J. T., Sellin, J., Mani, K., & Chopra, P. (2024) · Der Schmerz · doi:10.1007/s00482-023-00778-7 · Cited by 4
Stretched beyond the limit : Well-being and functioning in patients with Ehlers-Danlos syndrome and other hypermobility syndromes
Geenen, R., & Lumley (2018) · Utrecht University Repository (Utrecht University) · doi:10.3233/978-1-61499-878-5-i
Complexities of management of a urostomy in Ehlers-Danlos syndrome: a reflective account
Oxenham, J. (2016) · British Journal of Nursing · doi:10.12968/bjon.2016.25.5.s14 · Cited by 4
The effect of therapeutic exercises in individuals with joint hypermobility syndrome: a systematic review and meta-analysis
Ebrahimi, E., Nourbakhsh, S., Sheikhhoseini, R., Piri, H., Méndez-Rebolledo, G., & Mozafari, S. (2026) · Egyptian Rheumatology and Rehabilitation · doi:10.1186/s43166-026-00407-y · Cited by 3
10-Year Cumulative Incidence and Indications for Revision Total Joint Arthroplasty for Patients Who Have Ehlers-Danlos Syndrome
Kubsad, S., Thenuwara, S., Green, W., Kurian, S. J., Kishan, A., Harris, A. B., Golladay, G. J., & Thakkar, S. C. (2024) · The Journal of Arthroplasty · doi:10.1016/j.arth.2024.06.037 · Cited by 3
From the bedside to the bench and backwards: diagnostic approach and management of Ehlers-Danlos syndrome(s) in Italy
Castori, M., & Colombi, M. (2015) · Journal de Réadaptation Médicale Pratique et Formation en Médecine Physique et de Réadaptation · doi:10.1016/j.jrm.2015.08.003 · Cited by 3
Physical activity and sleep in patients with hypermobile Ehlers–Danlos syndrome and patients with generalized hypermobility spectrum disorder
Coussens, M., Wandele, I. D., Pacey, V., Malfait, F., Craemer, M. D., Demeyer, H., Rombaut, L., & Calders, P. (2020) · Edorium Journal of Disability and Rehabilitation · doi:10.5348/100049d05mc2020ra · Cited by 3
Foot Pain and Disability in Women with Rheumatoid Arthritis, Ehlers–Danlos Syndrome and Systemic Lupus Erythematosus: Relationship with Quality of Life
Palomo-Toucedo, I. C., Domínguez-Maldonado, G., Reina‐Bueno, M., Vázquez-Bautista, M. D. C., Ramos-Ortega, J., Castillo-López, J. M., & Munuera-Martínez, P. V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12196284 · Cited by 3
An online pain management program for people with hypermobile Ehlers-Danlos Syndrome or hypermobility spectrum disorder: a three-staged development process
Chew, M. T., İlhan, E., Nicholson, L. L., Kobayashi, S., & Chan, C. L. (2024) · Disability and Rehabilitation · doi:10.1080/09638288.2024.2351180 · Cited by 3
Prevalence of Pain and Effect of Joint Strength on Perceived Physical Function in Pediatric Patients With Ehlers–Danlos Syndrome
Garcia, N., Lytch, A., Cramer, E., Black, W. R., & Jones, J. T. (2024) · Archives of Rehabilitation Research and Clinical Translation · doi:10.1016/j.arrct.2024.100416 · Cited by 3
Impaired quality of life and functional status in patients with benign joint hypermobility syndrome
Şahin, E., Gülbahar, S., Baydar, M., Söylev, G. Ö., Bircan, Ç., El, Ö., Kızıl, R., & Peker, Ö. (2015) · MYOPAIN · doi:10.3109/10582452.2016.1143074 · Cited by 3
Ehlers-Danlos syndrome in chronic pain patient. Case report
Bem-Haja, P. L., Canga, J. C., de Abreu, Y. L. B., & Bedoni, F. M. (2016) · Revista Dor · doi:10.5935/1806-0013.20160035 · Cited by 3
What types of shoulder pain most commonly affect sleep quality? A scoping systematic review
Pawłuś, N., Granek, Z., Kanak, M., & Domżalski, M. E. (2023) · Chirurgia Narządów Ruchu i Ortopedia Polska · doi:10.31139/chnriop.2023.88.3.6 · Cited by 2
Liver transplantation in a patient with Ehlers-Danlos syndrome
Bohorquez, H. E., Gomez, D., Cohen, A. J., Bruce, D. S., CARMODY, I. C., Reichman, T., & Loss, G. E. (2013) · Liver Transplantation · doi:10.1002/lt.23627 · Cited by 2
Alteraciones podológicas en el síndrome de Ehlers-Danlos
Palomo-Toucedo, I. C., Vázquez-Bautista, C., Munuera-Martínez, P. V., Domínguez-Maldonado, G., Castillo-López, J. M., & Reina‐Bueno, M. (2019) · Medicina Clínica · doi:10.1016/j.medcli.2019.05.006 · Cited by 2
The Effect of Hypermobility on Pain and Quality of Life in Young Adults
Karaman, Ç. A., ZEREN, E., MARAL, F., Parlak, M., Kirazlı, Ö., BORACI, H., Zeren, M., & Arifoğlu, Y. (2022) · Bezmialem Science · doi:10.14235/bas.galenos.2022.55707 · Cited by 2
Sex differences in self-reported symptoms and comorbidities associated with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders: A retrospective studyPreprint
Wilson, F. C., Zangerle, D. J., Darakjian, A. A., Bhutani, M., Fliess, J. J., Gehin, J. M., Strandes, M. W., Hamilton, C., Sledge, H. J., Hodge, D. O., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-8310986/v1 · Cited by 2
Ehlers-Danlos heilkenni af gerð IV. Sjúkratilfelli og sjúkdómseinkenni
Gudmundsdottir, S. A., Möller, P. H., Arngrı́msson, R., & Arngrímsson, R. (2012) · Læknablaðið · doi:10.17992/lbl.2012.06.440 · Cited by 1
Outcomes of Total Joint Arthroplasty in Patients Who Have Ehlers-Danlos Syndrome: A Systematic Review and Meta-Analysis
Subramanian, T., Uzzo, R. N., Lama, J. E., Mazzucco, M., Ortiz, S., & Gausden, E. B. (2025) · The Journal of Arthroplasty · doi:10.1016/j.arth.2025.01.018 · Cited by 2
Pain and physical function affecting quality of life in patients with osteogenesis imperfecta, X-linked hypophosphatemia, and hypermobile Ehlers-Danlos syndrome
Moon, J.-Y., Inhestern, L., Landskron, N., Barvencik, F., Amling, M., & Oheim, R. (2025) · JBMR Plus · doi:10.1093/jbmrpl/ziaf076 · Cited by 1
Medicinal cannabis in the treatment of hypermobile Ehlers-Danlos syndrome & hypermobility spectrum disorder: Real-world evidence from Project Twenty21
Stafford, L. V., Lynskey, M. T., Schlag, A. K., Nutt, D., & Eccles, J. (2025) · Drug Science Policy and Law · doi:10.1177/20503245251398260 · Cited by 1
Comorbid Conditions of Ehlers–Danlos Syndromes and Vulvodynia: A Latent Class Analysis
Glayzer, J. E., Bray, B. C., Kobak, W. H., Trujillo, C., Patil, C. L., Li, H., Francomano, C. A., & Schlaeger, J. M. (2026) · Pain Management Nursing · doi:10.1016/j.pmn.2026.03.005 · Cited by 1
Painful subjects: the sociogenic processing of pain in individuals with Ehlers-Danlos syndromes
Doyle, T. A., Vershaw, S. L., & Halverson, C. M. E. (2026) · SSM - Mental Health · doi:10.1016/j.ssmmh.2026.100634 · Cited by 1
Ehlers–Danlos Syndrome in an Adult Woman: A Hidden Syndrome
Spinelli, D., Minonzio, F., Bassotti, A., Hu, C. M., & Cappellini, M. D. (2014) · European Journal of Case Reports in Internal Medicine · doi:10.12890/2014_000063 · Cited by 1
Podiatry alterations in Ehlers-Danlos syndrome
Palomo-Toucedo, I. C., Vázquez-Bautista, C., Munuera-Martínez, P. V., Domínguez-Maldonado, G., Castillo-López, J. M., & Reina‐Bueno, M. (2020) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2019.05.009 · Cited by 1
ESTUDO DE PREVALÊNCIA CARDIOVASCULAR EM CABO VERDE (ESTUDO PREVCARDIO.CV) - ILHA DO MAIO
COELHO, P. M. D. S. C., Rodrigues, F., & Adrião, L. L. D. S. (2021) · doi:10.22533/at.ed.5892117059 · Cited by 1
Authors’ Reply
Castori, M., Celletti, C., & Camerota, F. (2011) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2011.02.009 · Cited by 1
Ehlers-Danlos: A Literature Review and Case Report in a Colombian Woman with Multiple Comorbidities
Fajardo-Jiménez, M. J., Moreno, J., Mejía‐García, A., Villegas‐Lanau, A., Zapata, W., Restrepo, J. E., Montoya, G. P. C., & Hernández, J. C. (2022) · Genes · doi:10.3390/genes13112118 · Cited by 4
The Relations among the Fear-Avoidance Model of Chronic Pain, Fear of Falling, and Disability in hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorder
Chuchin, J. (2024) · doi:10.32920/25219379.v1 · Cited by 1
Réhabilitation conservatrice d'adultes atteints du syndrome d'hypermobilité
Nyffeler, R., & Grobety, T. (2014) · reroDoc Digital Library · doi:10.22005/bcu.17791
Functiestoornissen van het kaakgewricht
Naeije, M. (2015) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-0433-2_5
Reply to the letter to the editor by Marc Williams
Malfait, F., WENSTRUP, R. J., & Paepe, A. D. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e318207bf8f
Pain, pain management, and quality of life in Ehlers-Danlos related disorders
Dawson, T. A. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
Response to clinical and genetic aspects of Ehlers-Danlos syndrome, classic type
Williams, M. S. (2011) · Genetics in Medicine · doi:10.1097/gim.0b013e318207bf77
Hypermobilité du membre supérieur (épaule exceptée)
Vigneron, A.-M., Legoupil, N., & Quintrec, J.-S. G.-L. (2012) · Revue du Rhumatisme Monographies · doi:10.1016/j.monrhu.2012.04.003
Ehlers-Danlos Syndrome, Hypermobility Type Synonyms: EDS Hypermobility Type, EDS Type III, Ehlers-Danlos Syndrome Type III
Levy, H. P. (2013)
Physical Therapy for the Antepartum Hospitalized Patient With Ehlers-Danlos Syndrome
Schmidt, M. V., & Palombaro, K. M. (2013) · Journal of Womenʼs Health Physical Therapy · doi:10.1097/jwh.0b013e31829f5bb4
Anterior Cruciate Ligament Reconstruction in Patients with Hereditary Abnormalities Involving Connective Tissue
Maloney, M., & Nicandri, G. T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-38962-4.00125-9
Cambios en la función y calidad de vida en paciente con ehlers-danlos mediante un programa de ejercicio terapéutico y práctica
Gonzalez, A., & Fernández‐Pérez, J. J. (2020) · Journal of MOVE and Therapeutic Science · doi:10.37382/jomts.v2i2.31

Authors: Voermans, N. C., Knoop, H., Bleijenberg, G., & van Engelen, B. G.
Affiliations: Radboud University Medical Center (NL)
Corresponding author: Voermans, Nicol C.
ORCID: Voermans, Nicol C.
Knoop, Hans
Bleijenberg, Gijs
Venue: Journal of Pain and Symptom Management
Publisher: Elsevier BV
Published: 2010-09
Volume: 40
Issue: 3
Pages: 370-378
ISSN: 0885-3924 (ISSN-L)
DOI: 10.1016/j.jpainsymman.2009.12.026
OpenAlex: W2152518735
Cited by: 237
References: 26
Citations by year: 2026: 11 · 2025: 9 · 2024: 15 · 2023: 15 · 2022: 20 · 2021: 28 · 2020: 17 · 2019: 16 · 2018: 10 · 2017: 12 · 2016: 17 · 2015: 15 · 2014: 13 · 2013: 11 · 2012: 11
FWCI: 7.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3421 d)
Locations: Journal of Pain and Symptom Management (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
Keywords: Ehlers-Danlos syndrome, chronic pain, pain prevalence, pain intensity, functional disability, joint hypermobility, dislocations, previous surgery, sleep disorders, fatigue, analgesic use, hereditary connective tissue disorders, McGill Pain Questionnaire, Sickness Impact Profile, Checklist Individual Strength
MeSH terms: Activities of Daily Living, Adolescent, Adult, Aged, Aged, 80 and over, Analgesics, Cross-Sectional Studies, Ehlers-Danlos Syndrome, Fatigue, Female, Humans, Male, Middle Aged, Pain, Pain Measurement, Sleep Wake Disorders, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pain in Ehlers-Danlos Syndrome Is Common, Severe, and Associated with Functional Impairment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks