The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Inflammation, insulin, and endothelial function in overweight children and adolescents: The role of exercise
Open accessAbstract
Objectives To assess subclinical inflammation, fasting insulin, and endothelial function before and after exercise in overweight children and adolescents.Study design Twenty-five children (body mass index [BMI] >85th percentile) were assessed for brachial artery flow-mediated dilation (FMD), nitroglycerin-induced dilation, C-reactive protein (CRP), lipids, glucose, insulin, oral glucose tolerance, body composition, aerobic fitness (peak oxygen uptake [VO 2 peak]), and blood pressure. Twenty of these persons were equally and randomly assigned to either 8 weeks of stationary cycling or to a non-exercising control group.Results A baseline correlation was found between CRP and fasting insulin (r = 0.62; P < .001), which remained significant after adjusting for baseline variables (r = 0.53; P < .05). After 8 weeks, significant improvements were observed in the exercise group compared with the control group for VO 2 peak (exercise group = 21.8 +/- 2.1 to 23.2 +/- 1.5 mL/kg/minute vs control group = 23.4 +/- 1.6 to 20.9 +/- 2.2 mL/kg/minute; P < .05), high-density lipoprotein (HDL) cholesterol (exercise group = 1.02 +/- 0.03 to 1.10 +/- 0.04 mmol/L vs control group = 1.08 +/- 0.07 to 0.99 +/- 0.09 mmol/L; P < .05), and FMD area under the curve (AUC) (exercise group = 746 +/- 66 to 919 +/- 94 %*sec vs control group = 731 +/- 102 to 515 +/- 73 %*sec; P < .05).Conclusions In overweight children and adolescents, CRP is independently associated with fasting insulin. Eight weeks of aerobic exercise improves fitness, HDL cholesterol, and endothelial function in this group.
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“Studies have reported increased plasma/serum levels of the proinflammatory cytokine IL-6 in healthy subjects with advanced age (55-75 v. 26 -54 years) (174) , an increase of 0•016 pg/ml per year of life (175) and a significant increase with overall age (from 20 to 102 years) (176) , and in elderly diabetic subjects (65 -80 years) (177) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [177]
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Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
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Tseng, M.-L., Ho, C.-C., Chen, S.-C., Huang, Y.-C., Lai, C.-H., & Liaw, Y.-P. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.3.271 · Cited by 37
Physical Exercise and Metabolic Reprogramming
Batatinha, H. P., Lira, F. S., Kruger, K., & Rosa Neto, J. C. (2022) · Essential Aspects of Immunometabolism in Health and Disease · doi:10.1007/978-3-030-86684-6_12 · Cited by 5
Metadata
- Authors
- Kelly, A. S., Wetzsteon, R. J., Kaiser, D. R., Steinberger, J., Bank, A. J., & Dengel, D. R.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Kelly, Aaron S.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 145
- Issue
- 6
- Pages
- 731-736
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2077741425
- Cited by
- 297
- References
- 24
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 3 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 17 · 2015: 21 · 2014: 23 · 2013: 18 · 2012: 20
- FWCI
- 11.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association (M01-RR00400)
- Deutsches Krebsforschungszentrum
- National Institutes of Health (P30 DK, RR00400)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, 1 P30 DK 50456-08)
- National Center for Research Resources (M01RR000400, M01-RR00400)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- childhood obesity, overweight children and adolescents, subclinical inflammation, C-reactive protein, fasting insulin, endothelial function, flow-mediated dilation, aerobic exercise, stationary cycling, cardiorespiratory fitness, HDL cholesterol, nitroglycerin-induced dilation, peak oxygen uptake
- MeSH terms
- Adolescent, Blood Glucose, C-Reactive Protein, Child, Cholesterol, Endothelium, Vascular, Female, Nitroglycerin, Humans, Inflammation, Insulin, Insulin Resistance, Male, Obesity, Oxygen Consumption, Vasodilation, Vasodilator Agents, Exercise, Body Mass Index, Metabolic Syndrome
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