Cited by 297Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsPhysical Activity and Health

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Inflammation, insulin, and endothelial function in overweight children and adolescents: The role of exercise

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Kelly, Aaron S., Wetzsteon, Rachel J., Kaiser, Daniel R., Steinberger, Julia, Bank, Alan J., Dengel, Donald R.·2004·The Journal of Pediatrics

DOI 10.1016/j.jpeds.2004.08.004

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Abstract

Objectives To assess subclinical inflammation, fasting insulin, and endothelial function before and after exercise in overweight children and adolescents.Study design Twenty-five children (body mass index [BMI] >85th percentile) were assessed for brachial artery flow-mediated dilation (FMD), nitroglycerin-induced dilation, C-reactive protein (CRP), lipids, glucose, insulin, oral glucose tolerance, body composition, aerobic fitness (peak oxygen uptake [VO 2 peak]), and blood pressure. Twenty of these persons were equally and randomly assigned to either 8 weeks of stationary cycling or to a non-exercising control group.Results A baseline correlation was found between CRP and fasting insulin (r = 0.62; P < .001), which remained significant after adjusting for baseline variables (r = 0.53; P < .05). After 8 weeks, significant improvements were observed in the exercise group compared with the control group for VO 2 peak (exercise group = 21.8 +/- 2.1 to 23.2 +/- 1.5 mL/kg/minute vs control group = 23.4 +/- 1.6 to 20.9 +/- 2.2 mL/kg/minute; P < .05), high-density lipoprotein (HDL) cholesterol (exercise group = 1.02 +/- 0.03 to 1.10 +/- 0.04 mmol/L vs control group = 1.08 +/- 0.07 to 0.99 +/- 0.09 mmol/L; P < .05), and FMD area under the curve (AUC) (exercise group = 746 +/- 66 to 919 +/- 94 %*sec vs control group = 731 +/- 102 to 515 +/- 73 %*sec; P < .05).Conclusions In overweight children and adolescents, CRP is independently associated with fasting insulin. Eight weeks of aerobic exercise improves fitness, HDL cholesterol, and endothelial function in this group.

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Authors: Kelly, A. S., Wetzsteon, R. J., Kaiser, D. R., Steinberger, J., Bank, A. J., & Dengel, D. R.
Affiliations: University of Minnesota (US)
Corresponding author: Kelly, Aaron S.
ORCID: Kelly, Aaron S.
Kaiser, Daniel R.
Steinberger, Julia
Bank, Alan J.
Dengel, Donald R.
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 2004-12
Volume: 145
Issue: 6
Pages: 731-736
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/j.jpeds.2004.08.004
OpenAlex: W2077741425
Cited by: 297
References: 24
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 3 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 17 · 2015: 21 · 2014: 23 · 2013: 18 · 2012: 20
FWCI: 11.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association (M01-RR00400)
Deutsches Krebsforschungszentrum
National Institutes of Health (P30 DK, RR00400)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, 1 P30 DK 50456-08)
National Center for Research Resources (M01RR000400, M01-RR00400)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords: childhood obesity, overweight children and adolescents, subclinical inflammation, C-reactive protein, fasting insulin, endothelial function, flow-mediated dilation, aerobic exercise, stationary cycling, cardiorespiratory fitness, HDL cholesterol, nitroglycerin-induced dilation, peak oxygen uptake
MeSH terms: Adolescent, Blood Glucose, C-Reactive Protein, Child, Cholesterol, Endothelium, Vascular, Female, Nitroglycerin, Humans, Inflammation, Insulin, Insulin Resistance, Male, Obesity, Oxygen Consumption, Vasodilation, Vasodilator Agents, Exercise, Body Mass Index, Metabolic Syndrome

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Inflammation, insulin, and endothelial function in overweight children and adolescents: The role of exercise

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