Significant Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus
Open accessAbstract
Serum 25-hydroxyvitamin D was measured in 128 youth with type 1 diabetes mellitus. Less than 25% of the patients were vitamin D sufficient. Because individuals with type 1 diabetes mellitus possess multiple risk factors for skeletal fragility, ensuring vitamin D sufficiency throughout childhood and adolescence in this population seems especially warranted.
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A plethora of environmental influences have been purported to affect the epidemiology of type 1 diabetes, with infant and adolescent diets, vitamin D and vitamin D pathway constituents, and viruses receiving the most focus.
“A plethora of environmental influences have been purported to affect the epidemiology of type 1 diabetes,25 with infant and adolescent diets,26 vitamin D and vitamin D pathway constituents,27–29 and viruses receiving the most focus.30,31”
From Type 1 diabetes (2014) · cites this paper as [27]
The Methods and Results (page unavailable) show that this study measured vitamin D status in youth who already had type 1 diabetes, supporting vitamin D as a topic of research in this population. It does not examine whether vitamin D or its pathway constituents influence the incidence or epidemiology of type 1 diabetes; the diet and virus portions have separate citations. (LLM, conf=0.82)
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Research works printed but not linked: 18
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- [8]Ward DT Yau SK Mee AP Mawer EB Miller CA Garland HO Functional, molecular, and biochemical characterization of streptozotocin-induced diabetes J Am Soc Nephrol 2001 12 779 90 11274239
- [9]Manolagas SC Jilka RL Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis N Engl J Med 1995 332 305 11 7816067
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- [12]Pozzilli P Manfrini S Crino A Picardi A Leomanni C Cherubini V Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes Horm Metab Res 2005 37 680 3 16308836
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Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease
Muscogiuri, G., Mitri, J., Mathieu, C., Badenhoop, K., Tamer, G., Orio, F., Mezza, T., Vieth, R., Colao, A., & Pittas, A. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0158 · Cited by 157 · see citing works
Devaraj, S., Yun, J.-M., Duncan-Staley, C. R., & Jialal, I. (2011) · American Journal of Clinical Pathology · doi:10.1309/ajcpjgzqx42biaxl · Cited by 69 · see citing works
- Authors
- Svoren, B. M., Volkening, L. K., Wood, J. R., & Laffel, L. M. B.
- Affiliations
- Boston Children's Hospital (US)
- Joslin Diabetes Center (US)
- Corresponding author
- Svoren, Britta M.
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 154
- Issue
- 1
- Pages
- 132-134
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC2635941
- OpenAlex
- W1975376935
- Cited by
- 187
- References
- 0
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 11 · 2017: 15 · 2016: 15 · 2015: 11 · 2014: 14 · 2013: 24 · 2012: 14
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Charles H. Hood Foundation
- Eli Lilly and Company
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (K12DK63696, K12DK063696, L40 DK068871, R01DK046887)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- vitamin D deficiency, type 1 diabetes, youth, 25-hydroxyvitamin D, vitamin D sufficiency, bone fragility, bone health, childhood and adolescence
- MeSH terms
- Adolescent, Child, Child, Preschool, Cholecalciferol, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Ergocalciferols, Female, Glycated Hemoglobin, Humans, Male, Sunlight, Vitamin D Deficiency, Comorbidity, Multivariate Analysis
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