The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Low Vitamin D Levels Correlate With the Proinflammatory State in Type 1 Diabetic Subjects With and Without Microvascular Complications
Abstract
Epidemiologic studies link vitamin D deficiency to onset of type 1 diabetes mellitus (T1DM). T1DM exhibits increased inflammation, which is pronounced with microvascular complications (T1DM-MV). However, there are a paucity of data on vitamin D in T1DM-MV in relation to biomarkers of inflammation, and this formed the aim of the study. Healthy control subjects (n = 36), patients with T1DM (n = 24), and patients with T1DM-MV (n =26) were recruited. Serum vitamin D levels, monocyte toll-like receptor (TLR) 2 and TLR4 expression and nuclear factor-κB (NFκB) activity were assessed. Patients with T1DM and T1DM-MV were significantly vitamin D deficient compared with control subjects (P < .01). There was a significant negative correlation between vitamin D levels and high-sensitivity C-reactive protein, NFκB activity, and TLR4 expression (P < .05). Preincubation with vitamin D significantly decreased lipopolysaccharide-activated TLR4 expression and cytokine levels in monocytes (P < .05). Low vitamin D levels may contribute to increased inflammation in T1DM. Future studies will elucidate the immunomodulatory effects of vitamin D in decreasing vascular risk in this population.
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“I n another study, isoflavone-rich soya (107 mg/d as aglycone; 50 % as genestein) for 6 weeks did not affect sVCAM-1, sICAM-1 or sE-selectin concentrations in healthy postmenopausal women compared with isoflavone-poor soya (815) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [815]
Citations
Cites
Vitamin D Deficiency and Risk of Cardiovascular Disease
Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K. J., Benjamin, E. J., D’Agostino, R. B., Wolf, M. S., & Vasan, R. S. (2008) · Circulation · doi:10.1161/circulationaha.107.706127 · Cited by 2,423
High Prevalence of Vitamin D Inadequacy and Implications for Health
Holick, M. F. (2006) · Mayo Clinic Proceedings · doi:10.4065/81.3.353 · Cited by 2,037
Vitamin D: modulator of the immune system
Baeke, F., Takiishi, T., Korf, H., Gysemans, C. A., & Mathieu, C. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.04.001 · Cited by 1,333
Scragg, R. K. R., Sowers, M. R., & Bell, C. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2813 · Cited by 964
Systematic Review: Vitamin D and Cardiometabolic Outcomes
Pittas, A. G., Chung, M., Trikalinos, T., Mitri, J., Brendel, M., Patel, K., Lichtenstein, A. H., Lau, J., & Balk, E. M. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-5-201003020-00009 · Cited by 761
Monocytes from type 2 diabetic patients have a pro-inflammatory profile
Giulietti, A., van Etten, E., Overbergh, L., Stoffels, K., Bouillon, R., & Mathieu, C. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.10.007 · Cited by 400
Devaraj, S., Dasu, M. R. K., Rockwood, J., Winter, W. E., Griffen, S. C., & Jialal, I. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2185 · Cited by 374
Serum 25-Hydroxyvitamin D Concentration and Subsequent Risk of Type 2 Diabetes
Sarkkola, C., Knekt, P., Männistö, S., Rissanen, H. A., Laaksonen, M. A., Montonen, J., & Reunanen, A. (2007) · Diabetes Care · doi:10.2337/dc07-0292 · Cited by 336
Libby, P., Nathan, D. M., Abraham, K., Brunzell, J. D., Fradkin, J. E., Haffner, S. M., Hsueh, W., Rewers, M., Roberts, B. T., Savage, P. J., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.529651 · Cited by 265
Chonchol, M., & Scragg, R. K. R. (2006) · Kidney International · doi:10.1038/sj.ki.5002002 · Cited by 256
Research works printed but not linked: 1
- Devaraj, Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications [published online ahead of print February 11, 2010], Metabolism
Cited by
Sorted by citations
Vitamin D status and ill health: a systematic review
Autier, P., Boniol, M., Pizot, C., & Mullie, P. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70165-7 · Cited by 1,128
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
“Using data pooled from thirty-six healthy subjects, twenty-four type 1 diabetics and twenty-six type 1 diabetics with microvascular complications, Devaraj et al.((747)) found significant inverse relationships between serum 25(OH)D3 and CRP concentration, monocyte NF-kB activation and TLR4 expression.”
Toll-like receptors activation, signaling, and targeting: an overview
El-Zayat, S. R., Sibaii, H., & Mannaa, F. A. E. (2019) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-019-0227-2 · Cited by 603
“4 TLR signaling pathways as autoimmune, chronic inflammatory, and infectious diseases as well as cancer (Huang & Pope, 2009; Jialal et al., 2015; Gao et al., 2017; Isaza-Correa et al., 2014; Devaraj et al., 2011).”
BackgroundThe Non-Genomic Actions of Vitamin D
Hii, C. S. T., & Ferrante, A. (2016) · Nutrients · doi:10.3390/nu8030135 · Cited by 339
“Thus, the patients have higher plasma C-reactive protein and higher expression of TLR2/4 and NK-κB activity in their monocytes than controls [61].”
BackgroundToll-like Receptor Status in Obesity and Metabolic Syndrome: A Translational Perspective
Jialal, I., Kaur, H., & Devaraj, S. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3092 · Cited by 290
Metadata
- Authors
- Devaraj, S., Yun, J.-M., Duncan-Staley, C. R., & Jialal, I.
- Affiliations
- University of California Davis Medical Center (US)
- Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA
- Sacramento VA Medical Center (US)
- Venue
- American Journal of Clinical Pathology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-03-01
- Volume
- 135
- Issue
- 3
- Pages
- 429-433
- ISSN
- 0002-9173 (ISSN-L)
- 1943-7722
- OpenAlex
- W2036701286
- Cited by
- 69
- References
- 16
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 13
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Clinical Pathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK69801)
- National Center for Complementary and Integrative Health (K-24AT00596, K24AT000596)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- vitamin D deficiency, type 1 diabetes, diabetic microvascular complications, inflammation, TLR4, TLR2, NF-κB activity, C-reactive protein, monocytes, lipopolysaccharide, cytokines, immunomodulation
- MeSH terms
- NF-kappaB-Inducing Kinase, Adult, C-Reactive Protein, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Female, Humans, Inflammation, Male, Monocytes, Vitamin D Deficiency, Protein Serine-Threonine Kinases, Toll-Like Receptor 2, Toll-Like Receptor 4, Microvessels
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- CoChat. (2026). Citation check: Low Vitamin D Levels Correlate With the Proinflammatory State in Type 1 Diabetic Subjects With and Without Microvascular Complications. https://app.cochat.ai/papers/10.1309/ajcpjgzqx42biaxl
- The paper
- Devaraj, S., Yun, J.-M., Duncan-Staley, C. R., & Jialal, I. (2011). Low Vitamin D Levels Correlate With the Proinflammatory State in Type 1 Diabetic Subjects With and Without Microvascular Complications. American Journal of Clinical Pathology. https://doi.org/10.1309/ajcpjgzqx42biaxl
