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Detecting, Studying, and Treating Autism Early: The One-Year Well-Baby Check-Up Approach
Open accessAbstract
Objectives To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD).Study design The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation.Results Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of "other." Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75.Conclusions The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.
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“Studies show that when pediatricians and ASD specialty clinics work together, risk detection and diagnostic evaluation can occur as early as 12 to 20 months, and interventions soon thereafter [179, 181].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [179]
In the citing paper
“Studies demonstrate that ASD risk can be measured as young as 12 to 24 months using parent report screening tools such as the CSBS IT-Checklist and M-CHAT at well-baby check-ups with follow-up confirmation at ASD specialty clinics [179, 180].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [179]
In the citing paper
“Although several studies have shown that early signs of ASD can sometimes be detected using parent report screens as early as 126,7,8 or 18 months of age,9,10”
From Evaluation of the Diagnostic Stability of the Early Autism Spectrum Disorder Phenotype in the General Population Starting at 12 Months (2019) · cites this paper as [6]
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“However, we found that within the context of an early detection program,6 children can be reliably diagnosed with ASD several years earlier, as young as 14 months.”
From Evaluation of the Diagnostic Stability of the Early Autism Spectrum Disorder Phenotype in the General Population Starting at 12 Months (2019) · cites this paper as [6]
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What Happens After Autism Screening—Factors That Predict Evaluation Attendance
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Metadata
- Authors
- Pierce, K., Carter, C., Weinfeld, M., Desmond, J., Hazin, R., Bjork, R., & Gallagher, N.
- Affiliations
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Corresponding author
- Pierce, Karen
- ORCID
- Pierce, Karen
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 159
- Issue
- 3
- Pages
- 458-465.e6
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC3157595
- OpenAlex
- W2144372804
- Cited by
- 256
- References
- 31
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 18 · 2023: 13 · 2022: 22 · 2021: 16 · 2020: 20 · 2019: 17 · 2018: 25 · 2017: 12 · 2016: 16 · 2015: 17 · 2014: 18 · 2013: 19 · 2012: 17
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01mh083968-05)
- National Institute on Aging (R01AG022381)
- National Institute of Mental Health (R01-MH083968, U24MH081810, R01MH078165, R01MH089390, L30 MH091755, R01MH036840, R01MH081757, R01MH080134, P50MH081755, R01MH081873)
- National Institute of Neurological Disorders and Stroke (U01NS061264)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065272)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- autism spectrum disorder, early screening, infant screening, language delay, developmental delay, positive predictive value, false positives, autism diagnosis
- MeSH terms
- Attitude of Health Personnel, Autistic Disorder, California, Child Development, Developmental Disabilities, Child, Preschool, False Positive Reactions, Feasibility Studies, Follow-Up Studies, Humans, Infant, Language Development Disorders, Mass Screening, Pediatrics, Predictive Value of Tests, Surveys and Questionnaires, Early Diagnosis
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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