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Cited by 82Celiac Disease Research and ManagementEosinophilic EsophagitisWheat and Barley Genetics and Pathology

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Prevalence and Natural History of Potential Celiac Disease in At-Family-Risk Infants Prospectively Investigated from Birth

Lionetti, Elena, Castellaneta, Stefania, Pulvirenti, Alfredo, Tonutti, Elio, Francavilla, Ruggiero, Fasano, Alessio, Catassi, Carlo·2012·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2012.05.008
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Abstract

Objective To evaluate the frequency and the natural history of potential (serology positive/Marsh 0-1 histology) celiac disease (CD) in children with a family risk of CD and factors associated with potential instead of overt (serology positive/Marsh 2-3 histology) CD expression. Study design Two-year follow-up study of 96 children (57 females; mean age: 29 ± 12 months) prospectively investigated from birth with: (1) a CD-affected first-degree relative; (2) positivity of serum IgA anti-tissue transglutaminase (tTG) or IgG antigliadin and IgA deficiency; and (3) the results of small intestinal biopsy. Children with potential CD were advised to remain on a gluten containing diet, repeat the celiac antibodies every 6 months, and to have an intestinal biopsy performed in case of persistently high anti-tTG level. Factors discriminating between potential and overt CD were analyzed by decision tree analysis based on the C4.5 algorithm. Results Twenty-four children had potential and 72 overt CD. The stronger predictors of potential CD were lack of symptoms, anti-tTG level lower than 11-fold the upper normal limit, age lower than 24 months, and breastfeeding longer than 8 months. Eighteen out of 21 (86%) patients with potential CD continuing a gluten-containing diet became antibody negative, 1/21 (5%) developed overt CD, and 2/21 (9%) had fluctuating antibodies levels after 2 years. Conclusions The prevalence of potential CD and the percentage of short-term loss of CD-related-antibodie…

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Research works printed but not linked: 28

  1. Fasano, 2001, Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum, Gastroenterology, 120, 636, 10.1053/gast.2001.22123 · DOI
  2. Lionetti, 2011, New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatment, Int Rev Immunol, 30, 219, 10.3109/08830185.2011.602443 · DOI
  3. Di Sabatino, 2009, Coeliac disease, Lancet, 373, 1480, 10.1016/S0140-6736(09)60254-3 · DOI
  4. Koskinen, 2008, Gluten-dependent small bowel mucosal transglutaminase 2-specific IgA deposits in overt and mild enteropathy coeliac disease, J Pediatr Gastroenterol Nutr, 47, 436, 10.1097/MPG.0b013e31817b6dec · DOI
  5. Tosco, 2011, Natural history of potential celiac disease in children, Clin Gastroenterol Hepatol, 9, 320, 10.1016/j.cgh.2010.09.006 · DOI · Paper page
  6. Tjon, 2010, CD: how complicated can it get?, Immunogenetics, 62, 641, 10.1007/s00251-010-0465-9 · DOI
  7. Fasano, 2011, Early feeding practices and their impact on development of celiac disease, Nestle Nutr Workshop Ser Pediatr Program, 68, 201
  8. Simell, 2007, Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study, Am J Gastroenterol, 102, 2026, 10.1111/j.1572-0241.2007.01360.x · DOI
  9. Simell, 2005, Natural history of transglutaminase autoantibodies and mucosal changes in children carrying HLA-conferred celiac disease susceptibility, Scand J Gastroenterol, 40, 1182, 10.1080/00365520510024034 · DOI
  10. Lundin, 2005, Commentary: transient coeliac disease back on stage again?, Scand J Gastroenterol, 40, 1137, 10.1080/00365520500206608 · DOI
  11. Liu, 2003, Fluctuating transglutaminase autoantibodies are related to histologic features of celiac disease, Clin Gastroenterol Hepatol, 1, 356, 10.1053/S1542-3565(03)00180-0 · DOI
  12. Alarida, 2010, HLA-DQ2 and -DQ8 genotypes in celiac and healthy Libyan children, Dig Liver Dis, 42, 425, 10.1016/j.dld.2009.09.004 · DOI
  13. Romanos, 2009, Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease, Gastroenterology, 137, 834, 10.1053/j.gastro.2009.05.040 · DOI
  14. Oberhuber, 1999, The histopathology of coeliac disease: time for a standardized report scheme for pathologists, Eur J Gastroenterol Hepatol, 11, 1185, 10.1097/00042737-199910000-00019 · DOI
  15. Quinlan, 1986, Induction of decision trees, Machine Learning, 1, 81, 10.1023/A:1022643204877 · DOI · Paper page
  16. Breiman, 2001, Random forests, Machine Learning, 45, 5, 10.1023/A:1010933404324 · DOI · Paper page
  17. Waisbourd-Zinman, 2012, Spontaneous normalization of anti-tissue transglutaminase antibody levels is common in children with type 1 diabetes mellitus, Dig Dis Sci, 57, 1314, 10.1007/s10620-011-2016-0 · DOI
  18. Barker, 2004, Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY), J Clin Endocrinol Metab, 89, 3896, 10.1210/jc.2003-031887 · DOI
  19. Kurppa, 2011, Spontaneous negative seroconversion of endomysial antibodies does not exclude subsequent celiac disease, J Pediatr Gastroenterol Nutr, 53, 576, 10.1097/MPG.0b013e31821c974f · DOI
  20. Sperandeo, 2011, Potential celiac patients: a model of celiac disease pathogenesis, PLoS One, 6, e21281, 10.1371/journal.pone.0021281 · DOI
  21. Abadie, 2011, Integration of genetic and immunological insights into a model of celiac disease pathogenesis, Annu Rev Immunol, 29, 493, 10.1146/annurev-immunol-040210-092915 · DOI
  22. Troncone, 2011, Coeliac disease and gluten sensitivity, J Intern Med, 269, 582, 10.1111/j.1365-2796.2011.02385.x · DOI
  23. Hill, 2008, Coeliac disease: a biopsy is not always necessary for diagnosis, Aliment Pharmacol Ther, 27, 572, 10.1111/j.1365-2036.2008.03609.x · DOI
  24. Mubarak, 2011, A biopsy is not always necessary to diagnose celiac disease, J Pediatr Gastroenterol Nutr, 52, 554, 10.1097/MPG.0b013e3181ef8e50 · DOI
  25. Catassi, 2010, Celiac disease diagnosis: simple rules are better than complicated algorithms, Am J Med, 123, 691, 10.1016/j.amjmed.2010.02.019 · DOI
  26. Husby, 2012, ESPGHAN Guidelines for the Diagnosis of Celiac Disease in Children and Adolescents: an evidence-based approach, J Pediatr Gastroenterol Nutr, 54, 136, 10.1097/MPG.0b013e31821a23d0 · DOI · Paper page
  27. Tonutti, 2009, Diagnostic efficacy of the ELISA test for the detection of deamidated anti-gliadin peptide antibodies in the diagnosis and monitoring of celiac disease, J Clin Lab Anal, 23, 165, 10.1002/jcla.20313 · DOI
  28. Akobeng, 2006, Effect of breast feeding on risk of coeliac disease: a systematic review and meta-analysis of observational studies, Arch Dis Child, 91, 39, 10.1136/adc.2005.082016 · DOI

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Metadata

Authors
Lionetti, E., Castellaneta, S., Pulvirenti, A., Tonutti, E., Francavilla, R., Fasano, A., & Catassi, C.
Affiliations
  • University of Catania (IT)
  • Ospedale San Paolo (IT)
  • University of Bari Aldo Moro (IT)
  • University of Maryland, Baltimore (US)
  • Marche Polytechnic University (IT)
Corresponding author
Catassi, Carlo
ORCID
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2012-11
Volume
161
Issue
5
Pages
908-914.e2
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2012.05.008
OpenAlex
W2082657714
Cited by
82
References
0
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 23 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 12 · 2014: 11 · 2013: 1 · 2012: 1
FWCI
7.76
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
  • Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Health Sciences › Medicine › Gastroenterology › Eosinophilic Esophagitis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
Keywords
celiac disease, familial risk, infants, anti-tissue transglutaminase antibodies, anti-gliadin antibodies, IgA deficiency, gluten-containing diet, antibody serology, natural history (disease), breastfeeding, small bowel biopsy, decision tree analysis
MeSH terms
Algorithms, Biopsy, Celiac Disease, Child, Preschool, Family Health, Female, Glutens, HLA Antigens, Humans, Immunoglobulin A, Immunoglobulin G, Infant, Infant, Newborn, Male, Pediatrics, Phenotype, Prospective Studies, Transglutaminases, Risk, Prevalence

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