The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes
Open accessAbstract
Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.Results Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).Conclusions Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.
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“However, in the postnatal period (before surgery), a reduction of 20 per cent in cerebellar volume in neonates with SVP and TGA (n=19) has been observed.34”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
In the citing paper
“In neonatal studies, white matter and CGM are comparably reduced in TGA and SVP.34,39”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
In the citing paper
“In addition, the basal ganglia and thalami are smaller in SVP and TGA when compared with healthy controls, in both the fetal 38 and neonatal 34 period.”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
Citations
Cites
Abnormal brain development in newborns with congenital heart disease
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Brain maturation is delayed in infants with complex congenital heart defects
Licht, D. J., Shera, D. M., Clancy, R. R., Wernovsky, G., Montenegro, L. M., Nicolson, S. C., Zimmerman, R. A., Spray, T. L., Gaynor, J. W., & Vossough, A. (2009) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.10.025 · Cited by 629
An MRI Study of Neurological Injury Before and After Congenital Heart Surgery
Mahle, W. T., Tavani, F., Zimmerman, R. A., Nicolson, S. C., Galli, K. K., Gaynor, J. W., Clancy, R. R., Montenegro, L. M., Spray, T. L., Chiavacci, R. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000032908.33237.b1 · Cited by 541
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Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects
McQuillen, P. S., Barkovich, A. J., Hamrick, S. E. G., Perez, M., Ward, P., Glidden, D. V., Azakie, A., Karl, T., & Miller, S. P. (2007) · Stroke · doi:10.1161/01.str.0000247941.41234.90 · Cited by 379
Delayed cortical development in fetuses with complex congenital heart disease
Clouchoux, C., du Plessis, A. J., Bouyssi-Kobar, M., Tworetzky, W., McElhinney, D. B., Brown, D. W., Gholipour, A., Kudelski, D., Warfield, S. K., McCarter, R. J., et al. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs281 · Cited by 309
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Cited by
Sorted by citations
Brain Injury and Neurodevelopmental Outcome in Congenital Heart Disease: A Systematic Review
Mebius, M. J., Kooi, E. M. W., Bilardo, C. M., & Bos, A. F. (2017) · PEDIATRICS · doi:10.1542/peds.2016-4055 · Cited by 166
The neonatal brain in critical congenital heart disease: Insights and future directions
Peyvandi, S., Latal, B., Miller, S. P., & McQuillen, P. S. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.05.045 · Cited by 172
Self-citationCognitive and Executive Function in Congenital Heart Disease: A Meta-analysis
Feldmann, M., Bataillard, C., Ehrler, M., Ullrich, C., Knirsch, W., Gosteli, M., Held, U., & Latal, B. (2021) · PEDIATRICS · doi:10.1542/peds.2021-050875 · Cited by 152
Self-citationHuisenga, D. C., Gemert, S. L. B., Bergen, A. V., Sweeney, J. K., & Hadders‐Algra, M. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14512 · Cited by 128
Claessens, N. H. P., Algra, S. O., Ouwehand, T. L., Jansen, N. J. G., Schappin, R., Haas, F., Eijsermans, M. J. C., de Vries, L. S., Benders, M. J. N. L., & CHD Lifespan Study Group Utrecht (2018) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.13747 · Cited by 123
Metadata
- Authors
- von Rhein, M., Buchmann, A., Hagmann, C., Dave, H., Bernet, V., Scheer, I., Knirsch, W., Latal, B., Bernet, V., Bürki, C., Dave, H., Prêtre, R., Hagmann, C., Knirsch, W., Kretschmar, O., Kellenberger, C., Scheer, I., Latal, B., Liamlahi, R., von Rhein, M., Plecko, B. R., & Sennhauser, F. H.
- Affiliations
- University Hospital Zurich (CH)
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 167
- Issue
- 6
- Pages
- 1259-1263.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W1601921345
- Cited by
- 128
- References
- 29
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Else Kröner-Fresenius-Stiftung
- Schweizerische Herzstiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PMPDP3_129104)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- congenital heart disease, brain volumetry, fetal brain development, open heart surgery
- MeSH terms
- Brain, Developmental Disabilities, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Prospective Studies, Switzerland, Cohort Studies
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