The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes
Open accessAbstract
Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.Results Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).Conclusions Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.
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“However, in the postnatal period (before surgery), a reduction of 20 per cent in cerebellar volume in neonates with SVP and TGA (n=19) has been observed.34”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
In the citing paper
“In neonatal studies, white matter and CGM are comparably reduced in TGA and SVP.34,39”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
In the citing paper
“In addition, the basal ganglia and thalami are smaller in SVP and TGA when compared with healthy controls, in both the fetal 38 and neonatal 34 period.”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [34]
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Self-citationCognitive and Executive Function in Congenital Heart Disease: A Meta-analysis
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Metadata
- Authors
- von Rhein, M., Buchmann, A., Hagmann, C., Dave, H., Bernet, V., Scheer, I., Knirsch, W., Latal, B., Bernet, V., Bürki, C., Dave, H., Prêtre, R., Hagmann, C., Knirsch, W., Kretschmar, O., Kellenberger, C., Scheer, I., Latal, B., Liamlahi, R., von Rhein, M., Plecko, B. R., & Sennhauser, F. H.
- Affiliations
- University Hospital Zurich (CH)
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 167
- Issue
- 6
- Pages
- 1259-1263.e1
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W1601921345
- Cited by
- 128
- References
- 29
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 1
- FWCI
- 7.59
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Else Kröner-Fresenius-Stiftung
- Schweizerische Herzstiftung
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PMPDP3_129104)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- congenital heart disease, brain volumetry, fetal brain development, open heart surgery
- MeSH terms
- Brain, Developmental Disabilities, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Prospective Studies, Switzerland, Cohort Studies
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