Cited by 128Congenital Heart Disease StudiesFetal and Pediatric Neurological DisordersCongenital heart defects research

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Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes

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von Rhein, Michael, Buchmann, Andreas, Hagmann, Cornelia, Dave, Hitendu, Bernet, Vera, Scheer, Ianina, Knirsch, Walter, Latal, Beatrice, Bernet, Vera, Bürki, Christoph, Dave, Hitendu, Prêtre, René, Hagmann, Cornelia, Knirsch, Walter, Kretschmar, Oliver, Kellenberger, Christian, Scheer, Ianina, Latal, Beatrice, Liamlahi, Rabia, von Rhein, Michael, Plecko, Barbara R., Sennhauser, Felix H.·2015·The Journal of Pediatrics

DOI 10.1016/j.jpeds.2015.07.006

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Abstract

Objectives To determine neonatal global and regional brain volumes in infants with congenital heart disease (CHD) in comparison with healthy controls and to determine brain growth.Study design Prospective cohort study in infants undergoing open-heart surgery for complex CHD. Global and regional volumetric measurements on preoperative cerebral magnetic resonance imaging were manually segmented in children without overt brain lesions.Results Preoperative brain volumetry of 19 patients demonstrates reduction in total and regional brain volumes, without any specific regional predilection compared with 19 healthy control infants (total brain volume reduction: 21%, regional brain volume reduction 8%-28%, all P < .001).Conclusions Infants with CHD undergoing bypass surgery have smaller brain volumes prior to surgery without a specific regional predilection. This suggests a fetal origin of reduced brain growth.

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Authors: von Rhein, M., Buchmann, A., Hagmann, C., Dave, H., Bernet, V., Scheer, I., Knirsch, W., Latal, B., Bernet, V., Bürki, C., Dave, H., Prêtre, R., Hagmann, C., Knirsch, W., Kretschmar, O., Kellenberger, C., Scheer, I., Latal, B., Liamlahi, R., von Rhein, M., Plecko, B. R., & Sennhauser, F. H.
Affiliations: University Hospital Zurich (CH)
ORCID: Buchmann, Andreas
Prêtre, René
Kretschmar, Oliver
Kellenberger, Christian
Liamlahi, Rabia
Plecko, Barbara R.
Venue: The Journal of Pediatrics
Publisher: Elsevier BV
Published: 2015-12
Volume: 167
Issue: 6
Pages: 1259-1263.e1
ISSN: 0022-3476 (ISSN-L)
DOI: 10.1016/j.jpeds.2015.07.006
OpenAlex: W1601921345
Cited by: 128
References: 29
Citations by year: 2026: 10 · 2025: 13 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 12 · 2017: 10 · 2016: 6 · 2015: 1
FWCI: 7.59
Type: journal article
Language: en
Open access: green
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Pediatrics (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Else Kröner-Fresenius-Stiftung
Schweizerische Herzstiftung
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (PMPDP3_129104)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: congenital heart disease, brain volumetry, fetal brain development, open heart surgery
MeSH terms: Brain, Developmental Disabilities, Female, Heart Defects, Congenital, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Prospective Studies, Switzerland, Cohort Studies

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Severe Congenital Heart Defects Are Associated with Global Reduction of Neonatal Brain Volumes

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