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Cited by 34Congenital Heart Disease StudiesCongenital heart defects researchCardiovascular Conditions and Treatments

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Growth Asymmetry, Head Circumference, and Neurodevelopmental Outcomes in Infants with Single Ventricles

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Miller, Thomas A., Zak, Victor, Shrader, Peter, Ravishankar, Chitra, Pemberton, Victoria L., Newburger, Jane W., Shillingford, Amanda J., Dagincourt, Nicholas, Cnota, James F., Lambert, Linda M., Sananes, Renee, Richmond, Marc E., Hsu, Daphne T., Miller, Stephen G., Zyblewski, Sinai C., Williams, Richard V., Miller, Thomas A., Zak, Victor, Shrader, Peter, Ravishankar, Chitra, Pemberton, Victoria L., Newburger, Jane W., Shillingford, Amanda J., Dagincourt, Nicholas, Cnota, James F., Lambert, Linda M., Sananes, Renee, Richmond, Marc E., Hsu, Daphne T., Miller, Stephen G., Zyblewski, Sinai C., Williams, Richard V.·2016·The Journal of Pediatrics
DOI 10.1016/j.jpeds.2015.09.041PMC PMC4698012
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Abstract

Objective To assess the variability in asymmetric growth and its association with neurodevelopment in infants with single ventricle (SV). Study design We analyzed weight-for-age z-score minus head circumference-for-age z-score (HCAZ), relative head growth (cm/kg), along with individual growth variables in subjects prospectively enrolled in the Infant Single Ventricle Trial. Associations between growth indices and scores on the Psychomotor Developmental Index (PDI) and Mental Developmental Index (MDI) of the Bayley Scales of Infant Development-II (BSID-II) at 14 months were assessed. Results Of the 230 subjects enrolled in the Infant Single Ventricle trial, complete growth data and BSID-II scores were available in 168 (73%). Across the cohort, indices of asymmetric growth varied widely at enrollment and before superior cavopulmonary connection (SCPC) surgery. BSID-II scores were not associated with these asymmetry indices. In bivariate analyses, greater pre-SCPC HCAZ correlated with higher MDI (r = 0.21; P = .006) and PDI (r = 0.38; P < .001) and a greater HCAZ increase from enrollment to pre-SCPC with higher PDI (r = 0.15; P = .049). In multivariable modeling, pre-SCPC HCAZ was an independent predictor of PDI (P = .03), but not MDI. Conclusion In infants with SV, growth asymmetry was not associated with neurodevelopment at 14 months, but pre-SCPC HCAZ was associated with PDI. Asymmetric growth, important in other high-risk infants, is not a brain-sparing adaptation in infants with SV. Trial registration Clinicaltrials.gov: NCT00113087.

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Metadata

Authors
Miller, T. A., Zak, V., Shrader, P., Ravishankar, C., Pemberton, V. L., Newburger, J. W., Shillingford, A. J., Dagincourt, N., Cnota, J. F., Lambert, L. M., Sananes, R., Richmond, M. E., Hsu, D. T., Miller, S. G., Zyblewski, S. C., Williams, R. V., Miller, T. A., Zak, V., Shrader, P., Ravishankar, C., Pemberton, V. L., Newburger, J. W., Shillingford, A. J., Dagincourt, N., Cnota, J. F., Lambert, L. M., Sananes, R., Richmond, M. E., Hsu, D. T., Miller, S. G., Zyblewski, S. C., & Williams, R. V.
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
2016-01
Volume
168
Pages
220-225.e1
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/j.jpeds.2015.09.041
PMC
PMC4698012
OpenAlex
W2179975033
Cited by
34
References
1
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 1
FWCI
2.09
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HL068269, HL068270, HL068279, HL068281, HL068285, HL068292, HL068290, HL068288, HL085057, HL109781, HL109737)
  • US Food and Drug Administration's Office of Orphan Products Development
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
Keywords
single ventricle, asymmetric growth, head circumference, neurodevelopmental outcomes, psychomotor development, cognitive development, superior cavopulmonary connection, brain sparing, infants, weight-for-age z-score
MeSH terms
Angiotensin-Converting Enzyme Inhibitors, Cephalometry, Double-Blind Method, Enalapril, Female, Growth Disorders, Heart Defects, Congenital, Heart Ventricles, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Cardiovascular Abnormalities, Neurodevelopmental Disorders

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