Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects
Open accessAbstract
Objective To investigate the relationship between tissue-specific alterations in brain volume and neurobehavioral status in newborns with complex congenital heart defects preoperatively.Study design Three-dimensional volumetric magnetic resonance imaging was used to calculate tissue-specific brain volumes and a standardized neurobehavioral assessment was performed to assess neurobehavioral status in 35 full-term newborns admitted to the hospital before cardiopulmonary bypass surgery. Multiple linear regression models were performed to evaluate relationships between neurobehavioral status and brain volumes.Results Reduced subcortical gray matter (SCGM) volume and increased cerebrospinal fluid (CSF) volume were associated with poor behavioral state regulation (SCGM, P = .04; CSF, P = .007) and poor visual orienting (CSF, P = .003). In cyanotic newborns, reduced SCGM was associated with higher overall abnormal scores on the assessment (P = .001) and poor behavioral state regulation (P = .04), and increased CSF volume was associated with poor behavioral state regulation (P = .02), and poor visual orienting (P = .02). Conversely, acyanotic newborns showed associations between reduced cerebellar volume and poor behavioral state regulation (P = .03).Conclusion Abnormal neurobehavior is associated with impaired volumetric brain growth before open heart surgery in infants with complex congenital heart defects. This study highlights a need for routine preoperative screening and early intervention to improve neurodevelopmental outcomes.
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Smaller postnatal brain volumes in congenital heart disease are associated with abnormal neonatal neurobehavior.
“Smaller postnatal brain volumes in CHD are associated with abnormal neonatal neurobehavior.43”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [43]
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- Authors
- Owen, M., Shevell, M., Donofrio, M., Majnemer, A., McCarter, R., Vezina, G., Bouyssi-Kobar, M., Evangelou, I., Freeman, D., Weisenfeld, N., & Limperopoulos, C.
- Affiliations
- Children's National (US)
- McGill University Health Centre (CA)
- Boston Children's Hospital (US)
- Corresponding author
- Limperopoulos, Catherine
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 164
- Issue
- 5
- Pages
- 1121-1127.e1
- ISSN
- 0022-3476 (ISSN-L)
- PMC
- PMC4474232
- OpenAlex
- W1984369101
- Cited by
- 115
- References
- 44
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 20 · 2021: 4 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 8 · 2016: 9 · 2015: 6 · 2014: 4
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- complex congenital heart disease, neonates, brain volume, neurobehavior, subcortical gray matter, cerebrospinal fluid volume, cerebellar volume, visual orienting, cyanotic congenital heart disease, acyanotic congenital heart disease, neurodevelopmental outcomes, preoperative screening
- MeSH terms
- Brain, Brain Injuries, Cardiopulmonary Bypass, Female, Heart Defects, Congenital, Humans, Image Interpretation, Computer-Assisted, Infant, Newborn, Magnetic Resonance Imaging, Male, Neurologic Examination, Neuropsychological Tests, Organ Size, Prospective Studies, Observer Variation, Linear Models, Single-Blind Method, Infant Behavior, Imaging, Three-Dimensional, Preoperative Period
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