Psychiatric Disorders and Function in Adolescents with Tetralogy of Fallot
Abstract
Objectives To assess psychiatric disorders and function in adolescents with repaired tetralogy of Fallot (TOF) without and with a genetic diagnosis and to evaluate associations of functioning with medical factors, IQ, and demographics. Study design Adolescents with TOF (n = 91) and 87 healthy referents completed a clinician-rated structured psychiatric interview, parent-/self-report measures of psychopathology, and brain magnetic resonance imaging. Twenty-three of the adolescents with TOF had a known genetic diagnosis. Results The prevalence of anxiety disorders did not differ significantly between adolescents with TOF without genetic diagnosis (n = 68) and referents. Adolescents with TOF and a genetic diagnosis showed an increased lifetime prevalence of anxiety disorder (43%) and lower global psychosocial functioning (median, 70; IQR, 63-75) compared with adolescents with TOF without genetic diagnosis (15% and 83; IQR, 79-87, respectively; P = .04 and <.001, respectively) and referents (6% and 85; IQR, 76-90, respectively; P = .001 and <.001, respectively). Adolescents with TOF without and with a genetic diagnosis had a higher lifetime prevalence of attention deficit-hyperactivity disorder (ADHD) than referents (19% and 39%, respectively, vs 5%; P = .04 and .002, respectively) and worse outcomes on parent-/self-report ratings of anxiety and disruptive behavior compared with referents. Risk factors for anxiety, ADHD, and lower psychosocial functioning for adolescents with TOF without a genetic diagnosis included older age, male sex, and low IQ. Medical variables were not predictive of psychiatric outcomes. Conclusion Adolescents with TOF, particularly those with a genetic diagnosis, show increased rates of psychiatric disorder and dysfunction. Continued mental health screening and surveillance into young adulthood is warranted for adolescents with TOF.
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In TOF adolescents, lifetime prevalence of anxiety disorder was higher (43%) and global psychosocial functioning reduced in those with a genetic diagnosis compared to those without and to referents.
“lifetime prevalence of anxiety disorder was higher (43%) and global psychosocial functioning was reduced in TOF survivors with a genetic diagnosis”
From Neurodevelopmental Outcomes in Tetralogy of Fallot: A Systematic Review (2022) · cites this paper as [27]
TOF adolescents had increased lifetime prevalence of ADHD compared to healthy peers.
“increased lifetime prevalence of ADHD (Attention Deficit- Hyperactivity Disorder) in comparison to their healthy peers”
From Neurodevelopmental Outcomes in Tetralogy of Fallot: A Systematic Review (2022) · cites this paper as [27]
Cites
A Children's Global Assessment Scale (CGAS)
Shaffer, D. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790100074010 · Cited by 3,716 · see citing works
(1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1073 · Cited by 3,372 · see citing works
Marino, B. S., Lipkin, P. H., Newburger, J. W., Peacock, G., Gerdes, M., Gaynor, J. W., Mussatto, K. A., Uzark, K., Goldberg, C. S., Johnson, W. H., et al. (2012) · Circulation · doi:10.1161/cir.0b013e318265ee8a · Cited by 1,608 · see citing works
Self-citationNollert, G., Fischlein, T., Bouterwek, S., Böhmer, C., Klinner, W., & Reichart, B. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00318-5 · Cited by 761 · see citing works
Brain maturation is delayed in infants with complex congenital heart defects
Licht, D. J., Shera, D. M., Clancy, R. R., Wernovsky, G., Montenegro, L. M., Nicolson, S. C., Zimmerman, R. A., Spray, T. L., Gaynor, J. W., & Vossough, A. (2009) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.10.025 · Cited by 629 · see citing works
Clinical characteristics of anxiety disordered youth
Kendall, P. C., Compton, S. N., Walkup, J. T., Birmaher, B., Albano, A. M., Sherrill, J., Ginsburg, G., Rynn, M., McCracken, J., Gosch, E., et al. (2010) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2010.01.009 · Cited by 369 · see citing works
Long-term results after early primary repair of tetralogy of Fallot.
Bacha, E. A., Scheule, A. M., Zurakowski, D., Erickson, L. C., Hung, J., Lang, P., Mayer, J. E., del Nido, P. J., & Jonas, R. A. (2001) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2001.115156 · Cited by 240 · see citing works
Anxiety in medically ill children/adolescents
Pao, M., & Bosk, A. (2011) · Depression and Anxiety · doi:10.1002/da.20727 · Cited by 151 · see citing works
Attentional Dysfunction in Children After Corrective Cardiac Surgery in Infancy
Hövels-Gürich, H. H., Konrad, K., Skorzenski, D., Herpertz-Dahlmann, B., Messmer, B. J., & Seghaye, M.-C. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.10.069 · Cited by 139 · see citing works
Zeltser, I., Jarvik, G. P., Bernbaum, J., Wernovsky, G., Nord, A. S., Gerdes, M., Zackai, E., Clancy, R., Nicolson, S. C., Spray, T. L., et al. (2008) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.04.074 · Cited by 67 · see citing works
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Learning and Memory in Adolescents with Critical Biventricular Congenital Heart Disease
Cassidy, A. R., Newburger, J. W., & Bellinger, D. C. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000443 · Cited by 41 · see citing works
Self-citationHolst, L. M., Kronborg, J. B., Jepsen, J. R. M., Christensen, J. Ø., Vejlstrup, N. G., Juul, K., Bjerre, J. V., Bilenberg, N., & Ravn, H. B. (2020) · Cardiology in the Young · doi:10.1017/s1047951119003184 · Cited by 24 · see citing works
Neurodevelopmental Outcomes in Tetralogy of Fallot: A Systematic Review
Kordopati-Zilou, K., Sergentanis, T., Pervanidou, P., Sofianou-Petraki, D., Panoulis, K., Vlahos, N., & Eleftheriades, M. (2022) · Children · doi:10.3390/children9020264 · Cited by 21 · see citing works
- Authors
- Holland, J. E., Cassidy, A. R., Stopp, C., White, M. T., Bellinger, D. C., Rivkin, M. J., Newburger, J. W., & DeMaso, D. R.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- DeMaso, David R.
- ORCID
- Venue
- The Journal of Pediatrics
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 187
- Pages
- 165-173
- ISSN
- 0022-3476 (ISSN-L)
- OpenAlex
- W2614407619
- Cited by
- 61
- References
- 10
- Citations by year
- 2026: 9 · 2025: 3 · 2024: 5 · 2023: 11 · 2022: 11 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 2
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- tetralogy of Fallot, repaired congenital heart disease, adolescents, mental illness, anxiety disorders, attention deficit hyperactivity disorder, psychosocial functioning, genetic diagnosis, IQ, disruptive behavior, mental health screening
- MeSH terms
- Adolescent, Mental Disorders, Cross-Sectional Studies, Female, Humans, Intelligence Tests, Male, Parents, Psychometrics, Risk Factors, Tetralogy of Fallot, Prevalence, Self Report
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