The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Vascular nitric oxide: Beyond eNOS
Open accessAbstract
As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC) to produce cyclic guanosine monophosphate (cGMP), although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA) or production of cyclic inosine monophosphate (cIMP)] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS) but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis.
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Cites
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Cited by
Endothelial Dysfunction and Hypertension
Konukoglu, D., & Uzun, H. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/5584_2016_90 · Cited by 594
Metabolism of vascular smooth muscle cells in vascular diseases
Shi, J., Yang, Y., Cheng, A., Xu, G., & He, F. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00220.2020 · Cited by 366
Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358
Nitric oxide bioavailability dysfunction involves in atherosclerosis
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Duan, J., Ruan, B., Yan, X., Liang, L., Song, P., Yang, Z., Liu, Y., Dou, K., Han, H., & Wang, L. (2018) · Hepatology · doi:10.1002/hep.29834 · Cited by 153
Metadata
- Authors
- Zhao, Y., Vanhoutte, P. M., & Leung, S. W. S.
- Venue
- Journal of Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 129
- Issue
- 2
- Pages
- 83-94
- ISSN
- 1347-8613 (ISSN-L)
- OpenAlex
- W2181241483
- Cited by
- 826
- References
- 41
- FWCI
- 37.02
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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