Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates
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Nitrite metabolism can be activated by hypoxia, low pH and reactions with metalloproteins.
“Nitrite metabolism can be activated by hypoxia, low pH and reactions with metalloproteins[50–58].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [50]
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“In that study, hemoproteins showed little or no antagonism of the relaxant effects of nitroso compounds or nitroglycerin because the latter vasodilators first penetrate smooth muscle cells and subsequently release NO, which produces cGMP accumulation and relaxation.(9)•(40) Hemoproteins are unable to penetrate cells a…”
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“The only 5nitrosothiol that we have found to be stable in the solid form is 5-nitroso-A^-acetylpenicillamine, but in aqueous solution it readily decomposes to release NO.(19)”
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“Organic nitrates and other nitrosocompounds have been extensively studied as vasodilatory and antiplatelet agents,(15)-(18) and their common mechanism of action is thought to result from the release of NO.(8)-(9)-(12)-(19) The critical importance of thiol availability in mediating the effects of organic nitrates was”
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Brawley, L., Itoh, S., Torrens, C., Barker, A. C., Bertram, C. E., Poston, L., & Hanson, M. A. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000065731.00639.02 · Cited by 244 · see citing works
“(7, 8), endothelium-derived hyperpolarizing factor (9), and pros-”
Carlo, M. D., & Loeser, R. F. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10056 · Cited by 245 · see citing works
- Authors
- Ignarro, L. J., Lippton, H., Edwards, J. C., Baricos, W. H., Hyman, A. L., Kadowitz, P. J., & Gruetter, C. A.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1981-09
- Volume
- 218
- Issue
- 3
- Pages
- 739-749
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1907994445
- Cited by
- 1,633
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 10 · 2022: 11 · 2021: 6 · 2020: 8 · 2019: 14 · 2018: 23 · 2017: 10 · 2016: 15 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 27
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phosphodiesterase function and regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- vasorelaxation, organic nitrates, nitrite, sodium nitroprusside, nitric oxide, S-nitrosothiols, guanylate cyclase activation, cyclic GMP, nitroglycerin, isosorbide dinitrate, PETN, amyl nitrite, sodium nitrite, sulfhydryl groups, coronary arteries
- MeSH terms
- Animals, Biotransformation, Cats, Cattle, Coronary Vessels, Enzyme Activation, Female, Ferricyanides, Guanylate Cyclase, Hemodynamics, Male, Nitrates, Nitric Oxide, Nitrites, Nitroprusside, Nitroso Compounds, Vasodilator Agents, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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