Mass spectrometry imaging for drug distribution studies

Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization

Takáts, Z., Wiseman, J. M., Gologan, B., & Cooks, R. G. (2004) · Science · doi:10.1126/science.1104404 · Cited by 3,369 · see citing works

Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS

Caprioli, R. M., Farmer, T. B., & Gile, J. (1997) · Analytical Chemistry · doi:10.1021/ac970888i · Cited by 2,234 · see citing works

Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues

Stoeckli, M., Chaurand, P., Hallahan, D. E., & Caprioli, R. M. (2001) · Nature Medicine · doi:10.1038/86573 · Cited by 1,173 · see citing works

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry

Nemes, P., & Vértes, Á. (2007) · Analytical Chemistry · doi:10.1021/ac071181r · Cited by 816 · see citing works

Mass Spectrometric Imaging for Biomedical Tissue Analysis

Chughtai, K., & Heeren, R. M. A. (2010) · Chemical Reviews · doi:10.1021/cr100012c · Cited by 652 · see citing works

Tissue Imaging at Atmospheric Pressure Using Desorption Electrospray Ionization (DESI) Mass Spectrometry

Wiseman, J. M., Ifa, D. R., Song, Q., & Cooks, R. G. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200602449 · Cited by 627 · see citing works

A C60 Primary Ion Beam System for Time of Flight Secondary Ion Mass Spectrometry: Its Development and Secondary Ion Yield Characteristics

Weibel, D. E., Wong, S., Lockyer, N. P., Blenkinsopp, P., Hill, R., & Vickerman, J. C. (2003) · Analytical Chemistry · doi:10.1021/ac026338o · Cited by 544 · see citing works

Direct Molecular Analysis of Whole-Body Animal Tissue Sections by Imaging MALDI Mass Spectrometry

Khatib-Shahidi, S., Andersson, M., Herman, J. L., Gillespie, T. A., & Caprioli, R. M. (2006) · Analytical Chemistry · doi:10.1021/ac060788p · Cited by 500 · see citing works

Clathrate nanostructures for mass spectrometry

Northen, T. R., Yanes, Ó., Northen, M. T., et al. (2007) · Nature · doi:10.1038/nature06195 · Cited by 480 · see citing works

Desorption electrospray ionization mass spectrometry: Imaging drugs and metabolites in tissues

Wiseman, J. M., Ifa, D. R., Zhu, Y., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801066105 · Cited by 465 · see citing works

Latent Fingerprint Chemical Imaging by Mass Spectrometry

Ifa, D. R., Manicke, N. E., Dill, A. L., et al. (2008) · Science · doi:10.1126/science.1157199 · Cited by 408 · see citing works

Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring

Kroiß, J., Kaltenpoth, M., Schneider, B., Schwinger, M.-G., Hertweck, C., Maddula, R. K., Strohm, E., & Svatoš, A. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.331 · Cited by 389 · see citing works

Direct analysis of drug candidates in tissue by matrix‐assisted laser desorption/ionization mass spectrometry

Reyzer, M. L., Hsieh, Y., Ng, K., Korfmacher, W. A., & Caprioli, R. M. (2003) · Journal of Mass Spectrometry · doi:10.1002/jms.525 · Cited by 368 · see citing works

Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source

Touboul, D., Kollmer, F., Niehuis, E., et al. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.06.005 · Cited by 364 · see citing works

Tissue concentrations: do we ever learn?

Mouton, J. W., Theuretzbacher, U., Craig, W. A., Tulkens, P. M., Derendorf, H., & Cars, O. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm476 · Cited by 352 · see citing works

Fully automated liquid extraction‐based surface sampling and ionization using a chip‐based robotic nanoelectrospray platform

Kertész, V., & Berkel, G. J. V. (2009) · Journal of Mass Spectrometry · doi:10.1002/jms.1709 · Cited by 349 · see citing works

Automated Acoustic Matrix Deposition for MALDI Sample Preparation

Aerni, H. R., Cornett, D. S., & Caprioli, R. M. (2005) · Analytical Chemistry · doi:10.1021/ac051534r · Cited by 343 · see citing works

MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in Tissue

Cornett, D. S., Frappier, S. L., & Caprioli, R. M. (2008) · Analytical Chemistry · doi:10.1021/ac800617s · Cited by 343 · see citing works

Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry

Laskin, J., Heath, B. S., Roach, P. J., et al. (2011) · Analytical Chemistry · doi:10.1021/ac2021322 · Cited by 340 · see citing works

Advances in Imaging Secondary Ion Mass Spectrometry for Biological Samples

Boxer, S. G., Kraft, M. L., & Weber, P. M. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.050708.133634 · Cited by 309 · see citing works

MALDI mass spectrometric imaging of biological tissue sections

Rohner, T. C., Staab, D., & Stoeckli, M. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.032 · Cited by 303 · see citing works

Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections

Stoeckli, M., Staab, D., & Schweitzer, A. (2006) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2006.10.007 · Cited by 298 · see citing works

MALDI-MS imaging of features smaller than the size of the laser beam

Jurchen, J. C., Rubakhin, S. S., & Sweedler, J. V. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.06.006 · Cited by 284 · see citing works

Gold-Enhanced Biomolecular Surface Imaging of Cells and Tissue by SIMS and MALDI Mass Spectrometry

Altelaar, M. A. F., Klinkert, I., Jalink, K., de Lange, R. P. J., Adan, R. A. H., Heeren, R. M. A., & Piersma, S. R. (2005) · Analytical Chemistry · doi:10.1021/ac0513111 · Cited by 279 · see citing works

High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions

Prideaux, B., Dartois, V. A., Staab, D., Weiner, D. M., Goh, A., Via, L. E., Barry, C. E., & Stoeckli, M. (2011) · Analytical Chemistry · doi:10.1021/ac1029049 · Cited by 260 · see citing works

Normalization in MALDI-TOF imaging datasets of proteins: practical considerations

Deininger, S., Cornett, D. S., Paape, R., Becker, M. S., Pineau, C., Rauser, S., Walch, A. K., & Wolski, E. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4929-z · Cited by 253 · see citing works

Autoradiography, MALDI-MS, and SIMS-MS Imaging in Pharmaceutical Discovery and Development

Solon, E. G., Schweitzer, A., Stoeckli, M., & Prideaux, B. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9158-4 · Cited by 252 · see citing works

Maldi Imaging Mass Spectrometry: Bridging Biology and Chemistry in Drug Development

Castellino, S., Groseclose, M. R., & Wagner, D. S. (2011) · Bioanalysis · doi:10.4155/bio.11.232 · Cited by 236 · see citing works

Three-Dimensional Imaging of Metabolites in Tissues under Ambient Conditions by Laser Ablation Electrospray Ionization Mass Spectrometry

Nemes, P., Barton, A. A., & Vértes, Á. (2009) · Analytical Chemistry · doi:10.1021/ac900745e · Cited by 221 · see citing works

Fine Mapping the Spatial Distribution and Concentration of Unlabeled Drugs within Tissue Micro-Compartments Using Imaging Mass Spectrometry

Nilsson, A., Fehniger, T. E., Gustavsson, L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011411 · Cited by 214 · see citing works

Simultaneous Imaging of Small Metabolites and Lipids in Rat Brain Tissues at Atmospheric Pressure by Laser Ablation Electrospray Ionization Mass Spectrometry

Nemes, P., Woods, A. S., & Vértes, Á. (2010) · Analytical Chemistry · doi:10.1021/ac902245p · Cited by 212 · see citing works

Profiling and imaging of tissues by imaging ion mobility‐mass spectrometry

MCLEAN, J. A. J., Ridenour, W. B., & Caprioli, R. M. (2007) · Journal of Mass Spectrometry · doi:10.1002/jms.1254 · Cited by 209 · see citing works

Sample preparation issues for tissue imaging by imaging MS

Kaletaş, B. K., van der Wiel, I. M., Stauber, J., Dekker, L. J. M., Güzel, C., Kros, J. M., Luider, T. M., & Heeren, R. M. A. (2009) · PROTEOMICS · doi:10.1002/pmic.200800364 · Cited by 206 · see citing works

Automated MALDI Matrix Deposition Method with Inkjet Printing for Imaging Mass Spectrometry

Baluya, D. L., Garrett, T. J., & Yost, R. A. (2007) · Analytical Chemistry · doi:10.1021/ac070958d · Cited by 202 · see citing works

Matrix‐free UV‐laser desorption/ionization (LDI) mass spectrometric imaging at the single‐cell level: distribution of secondary metabolites of Arabidopsis thaliana and Hypericum species

Hölscher, D., Shroff, R., Knop, K., et al. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.04012.x · Cited by 197 · see citing works

Matrix-Assisted Laser Desorption/Ionization-Ion Mobility Separation-Mass Spectrometry Imaging of Vinblastine in Whole Body Tissue Sections

Trim, P. J., Henson, C., Avery, J. L., McEwen, A., Snel, M. F., Claude, E., Marshall, P. S., West, A., Princivalle, A. P., & Clench, M. R. (2008) · Analytical Chemistry · doi:10.1021/ac8015467 · Cited by 194 · see citing works

Imaging mass spectrometry: fundamentals and applications to drug discovery

Rubakhin, S. S., Jurchen, J. C., Monroe, E. B., & Sweedler, J. V. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03458-6 · Cited by 191 · see citing works

Matrix‐assisted laser desorption/ionization imaging mass spectrometry for direct measurement of clozapine in rat brain tissue

Hsieh, Y., Casale, R., Fukuda, E. K., et al. (2006) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2397 · Cited by 187 · see citing works

Comparison of Drug Distribution Images from Whole-Body Thin Tissue Sections Obtained Using Desorption Electrospray Ionization Tandem Mass Spectrometry and Autoradiography

Kertész, V., Berkel, G. J. V., Vavrek, M., et al. (2008) · Analytical Chemistry · doi:10.1021/ac800546a · Cited by 172 · see citing works

Liquid extraction surface analysis mass spectrometry (LESA‐MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example

Eikel, D., Vavrek, M., Smith, S., et al. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5274 · Cited by 169 · see citing works

High-Speed MALDI-TOF Imaging Mass Spectrometry: Rapid Ion Image Acquisition and Considerations for Next Generation Instrumentation

Spraggins, J. M., & Caprioli, R. M. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0121-0 · Cited by 169 · see citing works

Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer

Garrett, T. J., Conaway, M. C. P., Kovtoun, V. V., Bui, H. A., Izgarian, N., Stafford, G. C., & Yost, R. A. (2006) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2006.09.019 · Cited by 161 · see citing works

Determination of pharmaceutical compounds in skin by imaging matrix‐assisted laser desorption/ionisation mass spectrometry

Bunch, J., Clench, M. R., & Richards, D. S. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1725 · Cited by 159 · see citing works

Mass spectrometry imaging with high resolution in mass and space (HR2 MSI) for reliable investigation of drug compound distributions on the cellular level

Römpp, A., Guenther, S., Takáts, Z., et al. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4990-7 · Cited by 151 · see citing works

Improved imaging resolution in desorption electrospray ionization mass spectrometry

Kertész, V., & Berkel, G. J. V. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3662 · Cited by 149 · see citing works

Mass spectrometry imaging for drugs and metabolites

Greer, T., Sturm, R. M., & Li, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.032 · Cited by 136 · see citing works

Detection of pharmaceutical compounds in tissue by matrix-assisted laser desorption/ionization and laser desorption/chemical ionization tandem mass spectrometry with a quadrupole ion trap

Troendle, F. J., Reddick, C. D., & Yost, R. A. (1999) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(99)00103-8 · Cited by 131 · see citing works

Effect of Local Matrix Crystal Variations in Matrix-Assisted Ionization Techniques for Mass Spectrometry

Luxembourg, S. L., McDonnell, L. A., Duursma, M. C., Guo, X., & Heeren, R. M. A. (2003) · Analytical Chemistry · doi:10.1021/ac026434p · Cited by 126 · see citing works

Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues

Drexler, D. M., Garrett, T. J., Cantone, J. L., DITERS, R. W., Mitroka, J. G., Conaway, M. C. P., Adams, S. P., Yost, R. A., & Sanders, M. (2006) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2006.11.004 · Cited by 126 · see citing works

Three dimensional mapping of neuropeptides and lipids in crustacean brain by mass spectral imaging

Chen, R., Hui, L., Sturm, R. M., et al. (2009) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2009.01.017 · Cited by 125 · see citing works

C 60 Secondary Ion Mass Spectrometry with a Hybrid-Quadrupole Orthogonal Time-of-Flight Mass Spectrometer

Carado, A. J., Passarelli, M. K., Kozole, J., Wingate, J. E., Winograd, N., & Loboda, A. V. (2008) · Analytical Chemistry · doi:10.1021/ac801712s · Cited by 125 · see citing works

Nanostructure Initiator Mass Spectrometry: Tissue Imaging and Direct Biofluid Analysis

Yanes, Ó., Woo, H., Northen, T. R., et al. (2009) · Analytical Chemistry · doi:10.1021/ac802576q · Cited by 119 · see citing works

Single Hair Cocaine Consumption Monitoring by Mass Spectrometric Imaging

Siegel, T. P., Grivet, C., Kræmer, T., et al. (2011) · Analytical Chemistry · doi:10.1021/ac200610c · Cited by 118 · see citing works

Analysis of erlotinib and its metabolites in rat tissue sections by MALDI quadrupole time‐of‐flight mass spectrometry

Signor, L., Varesio, E., Staack, R. F., et al. (2007) · Journal of Mass Spectrometry · doi:10.1002/jms.1225 · Cited by 115 · see citing works

Chemical imaging of drug eluting coatings: Combining surface analysis and confocal Raman microscopy

Belu, A. M., Mahoney, C. M., & Wormuth, K. R. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.11.015 · Cited by 114 · see citing works

Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging

Marko‐Varga, G., Fehniger, T. E., Rezeli, M., Döme, B., Laurell, T., & Végvári, Á. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.03.019 · Cited by 112 · see citing works

AP-MALDI imaging of neuropeptides in mouse pituitary gland with 5μm spatial resolution and high mass accuracy

Guenther, S., Römpp, A., Kummer, W., et al. (2010) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2010.11.011 · Cited by 110 · see citing works

Quantitative analysis of pharmaceutical drug distribution in multiple organs by imaging mass spectrometry

Takai, N., Tanaka, Y., Inazawa, K., et al. (2012) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.6256 · Cited by 106 · see citing works

In Situ Primary Metabolites Localization on a Rat Brain Section by Chemical Mass Spectrometry Imaging

Benabdellah, F., Touboul, D., Brunelle, A., et al. (2009) · Analytical Chemistry · doi:10.1021/ac9005364 · Cited by 104 · see citing works

Combining Two-Dimensional Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopy, Imaging Desorption Electrospray Ionization Mass Spectrometry, and Direct Analysis in Real-Time Mass Spectrometry for the Integral Investigation of Counterfeit Pharmaceuticals

Nyadong, L., Harris, G. A., Balayssac, S., Galhena, A. S., Malet‐Martino, M., Martino, R., Parry, R. M., Wang, M. D., Fernández, F. M., & Gilard, V. (2009) · Analytical Chemistry · doi:10.1021/ac900384j · Cited by 103 · see citing works

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix‐assisted laser desorption/ionisation mass spectrometry

Atkinson, S. J., Loadman, P. M., Sutton, C. W., et al. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.2952 · Cited by 101 · see citing works

Why don’t biologists use SIMS?

Heeren, R. M. A., McDonnell, L. A., Amstalden, E. R., Luxembourg, S. L., Altelaar, M. A. F., & Piersma, S. R. (2006) · Applied Surface Science · doi:10.1016/j.apsusc.2006.02.134 · Cited by 101 · see citing works

Direct analysis of lipids and small metabolites in mouse brain tissue by AP IR-MALDI and reactive LAESI mass spectrometry

Shrestha, B., Nemes, P., Nazarian, J., et al. (2010) · The Analyst · doi:10.1039/b922854c · Cited by 100 · see citing works

Qualitative and Quantitative MALDI Imaging of the Positron Emission Tomography Ligands Raclopride (a D2 Dopamine Antagonist) and SCH 23390 (a D1 Dopamine Antagonist) in Rat Brain Tissue Sections Using a Solvent-Free Dry Matrix Application Method

Goodwin, R. J. A., Mackay, C. L., Nilsson, A., et al. (2011) · Analytical Chemistry · doi:10.1021/ac202630t · Cited by 95 · see citing works

A quantitation method for mass spectrometry imaging

Koeniger, S. L., Talaty, N. N., Luo, Y., et al. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4891 · Cited by 95 · see citing works

TOF-SIMS Characterization and Imaging of Controlled-Release Drug Delivery Systems

Belu, A. M., Davies, M. C., Newton, J. M., et al. (2000) · Analytical Chemistry · doi:10.1021/ac000450+ · Cited by 94 · see citing works

Introduction of a 20 kHz Nd:YVO4 laser into a hybrid quadrupole time-of-flight mass spectrometer for MALDI-MS imaging

Trim, P. J., Djidja, M., Atkinson, S. J., Oakes, K., Cole, L. M., Anderson, D. M., Hart, P. J., Francese, S., & Clench, M. R. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3874-6 · Cited by 93 · see citing works

Imaging of aβ-peptide distribution in whole-body mice sections by MALDI mass spectrometry

Stoeckli, M., Staab, D., Schweitzer, A., et al. (2007) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2007.08.005 · Cited by 92 · see citing works

Quantitative Tandem Mass Spectrometric Imaging of Endogenous Acetyl- l -carnitine from Piglet Brain Tissue Using an Internal Standard

Pirman, D. A., & Yost, R. A. (2011) · Analytical Chemistry · doi:10.1021/ac201949b · Cited by 87 · see citing works

Reagent Precoated Targets for Rapid In-Tissue Derivatization of the Anti-Tuberculosis Drug Isoniazid Followed by MALDI Imaging Mass Spectrometry

Manier, M. L., Reyzer, M. L., Goh, A., et al. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0150-8 · Cited by 82 · see citing works

Direct Profiling and Imaging of Epicuticular Waxes on Arabidopsis thaliana by Laser Desorption/Ionization Mass Spectrometry Using Silver Colloid as a Matrix

Cha, S., Song, Z., Nikolau, B. J., et al. (2009) · Analytical Chemistry · doi:10.1021/ac802615r · Cited by 81 · see citing works

Localization and Analyses of Small Drug Molecules in Rat Brain Tissue Sections

Wang, H.-Y. J., Jackson, S. N., McEuen, J., et al. (2005) · Analytical Chemistry · doi:10.1021/ac050868d · Cited by 76 · see citing works

Use of a Solvent-Free Dry Matrix Coating for Quantitative Matrix-Assisted Laser Desorption Ionization Imaging of 4-Bromophenyl-1,4-diazabicyclo(3.2.2)nonane-4-carboxylate in Rat Brain and Quantitative Analysis of the Drug from Laser Microdissected Tissue Regions

Goodwin, R. J. A., Scullion, P., MacIntyre, L., et al. (2010) · Analytical Chemistry · doi:10.1021/ac100398y · Cited by 75 · see citing works

A new time‐of‐flight SIMS instrument for 3D imaging and analysis

Hill, R., Blenkinsopp, P., Thompson, S., et al. (2010) · Surface and Interface Analysis · doi:10.1002/sia.3562 · Cited by 75 · see citing works

Nanostructure-initiator mass spectrometry (NIMS) imaging of brain cholesterol metabolites in Smith-Lemli-Opitz syndrome

Patti, G. J., Shriver, L. P., Wassif, C. A., Woo, H. K., Uritboonthai, W., Apon, J. V., Manchester, M., Porter, F. D., & Siuzdak, G. E. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.038 · Cited by 74 · see citing works

On‐tissue chemical derivatization of 3‐methoxysalicylamine for MALDI‐imaging mass spectrometry

Chacon, A., Zagol-Ikapitte, I. A., Amarnath, V., et al. (2011) · Journal of Mass Spectrometry · doi:10.1002/jms.1958 · Cited by 70 · see citing works

Methods to Assess Tissue-Specific Distribution and Metabolism of Drugs

Langer, O., & Müller, M. (2004) · Current Drug Metabolism · doi:10.2174/1389200043335379 · Cited by 68 · see citing works

Direct Demonstration of Tissue Uptake of an Inhaled Drug: Proof-of-Principle Study Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging

Fehniger, T. E., Végvári, Á., Rezeli, M., et al. (2011) · Analytical Chemistry · doi:10.1021/ac2014349 · Cited by 68 · see citing works

Small animal PET in preclinical studies: opportunities and challenges.

Riemann, B., Schäfers, K. P., Schober, O., et al. (2008) · PubMed · Cited by 67 · see citing works

Matrix Pre-Coated MALDI MS Targets for Small Molecule Imaging in Tissues

Grove, K. J., Frappier, S. L., & Caprioli, R. M. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-010-0013-8 · Cited by 65 · see citing works

The application of MALDI TOF MS in biopharmaceutical research

Kafka, A. P., Kleffmann, T., Rades, T., et al. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.010 · Cited by 64 · see citing works

C60 Secondary Ion Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Smith, D. F., Robinson, E. W., Tolmachev, A. V., Heeren, R. M. A., & Paša‐Tolić, L. (2011) · Analytical Chemistry · doi:10.1021/ac2023348 · Cited by 63 · see citing works

Controlled-pH Tissue Cleanup Protocol for Signal Enhancement of Small Molecule Drugs Analyzed by MALDI-MS Imaging

Shariatgorji, M., Källback, P., Gustavsson, L., et al. (2012) · Analytical Chemistry · doi:10.1021/ac203322q · Cited by 62 · see citing works

Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments

Strohalm, M., Strohalm, J., Kaftan, F., et al. (2011) · Analytical Chemistry · doi:10.1021/ac2011679 · Cited by 62 · see citing works

Correlation of Skin Blanching and Percutaneous Absorption for Glucocorticoid Receptor Agonists by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Liquid Extraction Surface Analysis with Nanoelectrospray Ionization Mass Spectrometry

Marshall, P. S., Djomte, V. T., Bareille, P. J., et al. (2010) · Analytical Chemistry · doi:10.1021/ac1017524 · Cited by 61 · see citing works

Three-Dimensional Time-of-Flight Secondary Ion Mass Spectrometry Imaging of a Pharmaceutical in a Coronary Stent Coating as a Function of Elution Time

Fisher, G. L., Belu, A. M., Mahoney, C. M., et al. (2009) · Analytical Chemistry · doi:10.1021/ac901587k · Cited by 61 · see citing works

Matrix‐assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)‐like treated rat kidney

Bouslimani, A., Bec, N., Glueckmann, M., et al. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4408 · Cited by 61 · see citing works

A mass spectrometry based imaging method developed for the intracellular detection of HIV protease inhibitors

Dekker, L. J. M., van Kampen, J. J. A., Reedijk, M. L., et al. (2009) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3981 · Cited by 50 · see citing works

Direct analysis of pharmaceutical tablet formulations using matrix‐assisted laser desorption/ionisation mass spectrometry imaging

Earnshaw, C. J., Carolan, V. A., Richards, D. S., & Clench, M. R. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4525 · Cited by 45 · see citing works

Drug Tissue Distribution: Study Methods and Therapeutic Implications

Lanao, J. M., & Fraile, M. (2005) · Current Pharmaceutical Design · doi:10.2174/138161205774580679 · Cited by 45 · see citing works

Distribution of chloroquine in ocular tissue of pigmented rat using matrix‐assisted laser desorption/ionization imaging quadrupole time‐of‐flight tandem mass spectrometry

Yamada, Y., Hidefumi, K., Shion, H., et al. (2011) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.5021 · Cited by 44 · see citing works

Utility of spatially-resolved atmospheric pressure surface sampling and ionization techniques as alternatives to mass spectrometric imaging (MSI) in drug metabolism

Blatherwick, E. Q., Berkel, G. J. V., Pickup, K., et al. (2011) · Xenobiotica · doi:10.3109/00498254.2011.587550 · Cited by 41 · see citing works

Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry

Végvári, Á., Fehniger, T. E., Gustavsson, L., et al. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.02.021 · Cited by 41 · see citing works

A solvent‐free matrix application method for matrix‐assisted laser desorption/ionization imaging of small molecules

Goodwin, R. J. A., MacIntyre, L., Watson, D. G., et al. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4567 · Cited by 40 · see citing works

Applications of MALDI-MSI to Pharmaceutical Research

Prideaux, B., Staab, D., & Stoeckli, M. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-746-4_23 · Cited by 39 · see citing works

The significance of ambient‐temperature on pharmaceutical and endogenous compound abundance and distribution in tissues sections when analyzed by matrix‐assisted laser desorption/ionization mass spectrometry imaging

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Investigation of Figopitant and Its Metabolites in Rat Tissue by Combining Whole-Body Autoradiography with Liquid Extraction Surface Analysis Mass Spectrometry

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Visualization of First-Pass Drug Metabolism of Terfenadine by MALDIImaging Mass Spectrometry

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Automated imaging MS: Toward high throughput imaging mass spectrometry

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Mass spectrometry imaging is moving toward drug protein co-localization

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Sucrose cryo‐protection facilitates imaging of whole eye sections by MALDI mass spectrometry

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Matrix‐free mass spectrometric imaging using laser desorption ionisation F ourier transform ion cyclotron resonance mass spectrometry

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ToF-SIMS Analysis of Dexamethasone Distribution in the Isolated Perfused Eye

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Laser microprobe mass spectrometry: potential and limitations for inorganic and organic micro-analysis

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Microstructure and Elution of Tetracycline from Block Copolymer Coatings

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Mapping Pharmaceuticals in Rat Brain Sections Using MALDI Imaging Mass Spectrometry

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XPS and TOF-SIMS Microanalysis of a Peptide/Polymer Drug Delivery Device

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Determination of loperamide in Mdr1a/1b knock-out mouse brain tissue using matrix-assisted laser desorption/ionization mass spectrometry and comparison with quantitative electrospray-triple quadrupole mass spectrometry analysis

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How to design preclinical studies in nanomedicine and cell therapy to maximize the prospects of clinical translation

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Unraveling drug penetration of echinocandin antifungals at the site of infection in an intra-abdominal abscess model

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Mass Spectrometry Imaging

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Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry of Drug Distribution in Mouse Brain Tissue by High-Resolution Time-of-Flight Mass Spectrometry

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Metabolite imaging by mass spectrometry: A new discovery tool

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The application of mass spectrometry imaging in traditional Chinese medicine: a review

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Mass spectrometry imaging: Facts and perspectives from a non-mass spectrometrist point of view

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Fundamentals of imaging mass spectrometry

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