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Cited by 104Stress Responses and CortisolCircadian rhythm and melatoninTreatment of Major Depression

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

24-h Monitoring of plasma norepinephrine, MHPG, cortisol, growth hormone and prolactin in depression

Koenigsberg, Harold W., Teicher, Martin H., Mitropoulou, Vivian, Navalta, Carryl, New, Antonia S., Trestman, Robert, Siever, Larry J.·2004·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2004.03.006
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Abstract

Unlabelled Depression is associated with alterations in hormone and catecholamine circadian rhythms. Analysis of these alterations has the potential to distinguish between three neurobiological models of depression, the catecholamine model, the phase advance model and the dysregulation model. Although a number of studies of 24-h rhythms have been reported, inconsistencies among the findings have complicated efforts to model the chronobiology of depression. The present study takes advantage of frequent plasma sampling over the 24-h period and a multioscillator cosinor model to fit the 24-h rhythms.Method Plasma levels of norepinephrine, cortisol, prolacatin and growth hormone were sampled at 30-min intervals, and MHPG at 60-min intervals, over a 24-h period in 22 patients with major depressive disorder and 20 healthy control volunteers.Results The depressed patients had phase advanced circadian rhythms for cortisol, norepinephrine and MHPG, phase advanced hemicircadian rhythms for cortisol and prolactin, and a phase advanced ultradian rhythm for prolactin compared to healthy control subjects. In addition, the rhythm-corrected 24-h mean value (mesor) of norepinephrine was lower in the depressed patients compared to the healthy controls. There also was a poorer goodness-of-fit for norepinephrine to the circadian oscillator in the depressed patients relative to the healthy controls.Conclusions These findings provide partial support for the dysregulation model of depression and are consistent with those studies that have found phase advances in cortisol, norepinephrine and MHPG rhythms in depression.

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  1. Papousek, 1975, Chronobiologische Aspekte der Zyklothymie, Fortsch. Neurol. Psychiat, 43, 381

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Metadata

Authors
Koenigsberg, H. W., Teicher, M. H., Mitropoulou, V., Navalta, C., New, A. S., Trestman, R., & Siever, L. J.
Affiliations
  • James J. Peters VA Medical Center (US)
  • Harvard University (US)
  • Icahn School of Medicine at Mount Sinai (US)
  • UConn Health (US)
  • Veterans Health Administration (US)
Corresponding author
Koenigsberg, Harold W.
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2004-09
Volume
38
Issue
5
Pages
503-511
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2004.03.006
OpenAlex
W1967191643
Cited by
104
References
54
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 8 · 2012: 6
FWCI
1.21
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Institutes of Health
  • National Center for Research Resources (5 M01RR00071, M01RR000071)
  • NIH Clinical Center
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
depression, major depressive disorder, circadian rhythm, ultradian rhythms, norepinephrine, MHPG, cortisol, growth hormone, prolactin, phase advance, chronobiology, cosinor analysis, mesor
MeSH terms
Adult, Circadian Rhythm, Depressive Disorder, Female, Humans, Hydrocortisone, Male, Methoxyhydroxyphenylglycol, Middle Aged, Models, Biological, Norepinephrine, Prolactin, Human Growth Hormone

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