Proteome and transcriptome analysis suggests oligodendrocyte dysfunction in schizophrenia
Abstract
Despite all the efforts regarding the treatment of schizophrenia patients and the growing advances in molecular diagnosis studies, the biochemical basis of this debilitating psychotic mental disorder that affects approximately 1% of the world's population is still not completely comprehended. Several recent clinical and molecular studies, using transcriptome and proteome analyses (TPA), for example, have described the oligodendrocyte dysfunction as a significant feature of the disease. TPA has been extensively used as a biomarker discovery tool, but a detailed and careful interpretation of the generated data can also provide a picture of the integrated biochemical systems that lead to the disease. This review presents the oligodendrocyte role players in schizophrenia pathogenesis as revealed by transcriptome and proteome studies. The presented data contribute to the composition of a scenario that may lead to a better understanding of schizophrenia pathogenesis.
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Molecular studies show reduced expression of multiple genes associated with node of Ranvier integrity in schizophrenia.
“molecular studies showing a reduction in expression level of multiple genes associated with the integrity of the node of Ranvier”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Martins-de-Souza, 2010
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- Authors
- Martins-de-Souza, D.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 44
- Issue
- 3
- Pages
- 149-156
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2110790178
- Cited by
- 81
- References
- 68
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 9 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 5 · 2015: 9 · 2014: 5 · 2013: 4 · 2012: 12
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, oligodendrocytes, oligodendrocyte dysfunction, proteome, transcriptome, schizophrenia pathogenesis, biomarkers, white matter
- MeSH terms
- Brain, Humans, Oligodendroglia, Schizophrenia, Gene Expression Profiling, Proteomics
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